Genular: Defining Cellular Identity and Function

Details for: Igf1

Gene ID: 24482

Symbol: Igf1

Ensembl ID: ENSRNOG00000004517

Description: insulin-like growth factor 1

Associated with

Hemostasis
(R-RNO-109582)
Igf1r signaling cascade
(R-RNO-2428924)
Irs-related events triggered by igf1r
(R-RNO-2428928)
Metabolism of proteins
(R-RNO-392499)
Peptide hormone metabolism
(R-RNO-2980736)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-RNO-381426)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Shc-related events triggered by igf1r
(R-RNO-2428933)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-RNO-2404192)
Synthesis, secretion, and deacylation of ghrelin
(R-RNO-422085)
Androgen receptor signaling pathway
(GO:0030521)
Blood vessel remodeling
(GO:0001974)
Bone mineralization involved in bone maturation
(GO:0035630)
Cardiac atrium development
(GO:0003230)
Cell activation
(GO:0001775)
Cell population proliferation
(GO:0008283)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to zinc ion starvation
(GO:0034224)
Cerebellar granule cell precursor proliferation
(GO:0021930)
Circadian rhythm
(GO:0007623)
Exocrine pancreas development
(GO:0031017)
Female pregnancy
(GO:0007565)
Glial cell differentiation
(GO:0010001)
Growth factor activity
(GO:0008083)
Hormone activity
(GO:0005179)
Insulin-like growth factor receptor binding
(GO:0005159)
Insulin receptor binding
(GO:0005158)
Integrin binding
(GO:0005178)
Lung development
(GO:0030324)
Mammary gland development
(GO:0030879)
Memory
(GO:0007613)
Multicellular organism growth
(GO:0035264)
Muscle hypertrophy
(GO:0014896)
Myotube cell development
(GO:0014904)
Myotube differentiation
(GO:0014902)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell communication
(GO:0010648)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of immune system process
(GO:0002683)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Negative regulation of signaling
(GO:0023057)
Negative regulation of smooth muscle cell apoptotic process
(GO:0034392)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nervous system development
(GO:0007399)
Osteoblast differentiation
(GO:0001649)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cerebellar granule cell precursor proliferation
(GO:0021940)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glycoprotein biosynthetic process
(GO:0010560)
Positive regulation of insulin-like growth factor receptor signaling pathway
(GO:0043568)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of myelination
(GO:0031643)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein serine/threonine kinase activator activity
(GO:0043539)
Proteoglycan biosynthetic process
(GO:0030166)
Receptor ligand activity
(GO:0048018)
Regulation of cell population proliferation
(GO:0042127)
Regulation of establishment or maintenance of cell polarity
(GO:0032878)
Regulation of gene expression
(GO:0010468)
Regulation of protein phosphorylation
(GO:0001932)
Regulation of translation
(GO:0006417)
Response to activity
(GO:0014823)
Response to caffeine
(GO:0031000)
Response to estradiol
(GO:0032355)
Response to heat
(GO:0009408)
Response to hypoxia
(GO:0001666)
Response to lipopolysaccharide
(GO:0032496)
Response to mechanical stimulus
(GO:0009612)
Response to nicotine
(GO:0035094)
Response to nutrient
(GO:0007584)
Response to nutrient levels
(GO:0031667)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to starvation
(GO:0042594)
Signal transduction
(GO:0007165)
Skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
(GO:0014834)
Steroid binding
(GO:0005496)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)
Type b pancreatic cell proliferation
(GO:0044342)
Wound healing
(GO:0042060)

Other Information

Proteins

Genular Protein ID: 3335553305

Symbol: IGF1_RAT

Name: Insulin-like growth factor I

UniProtKB Accession Codes:

P08025 P08024

Database IDs:

Citations:

PubMed ID: 3034909

Title: Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene.

PubMed ID: 3034909

DOI: 10.1016/s0021-9258(18)47652-1

PubMed ID: 3652906

Title: Isolation of rat testis cDNAs encoding an insulin-like growth factor I precursor.

PubMed ID: 3652906

DOI: 10.1089/dna.1987.6.325

PubMed ID: 3453891

Title: Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues.

PubMed ID: 3453891

DOI: 10.1210/mend-1-3-243

PubMed ID: 3658684

Title: Sequence of two rat insulin-like growth factor I mRNAs differing within the 5' untranslated region.

PubMed ID: 3658684

DOI: 10.1093/nar/15.17.7196

PubMed ID: 1368571

Title: A new cDNA clone relating to larger molecular species of rat insulin-like growth factor-I mRNA.

PubMed ID: 1368571

DOI: 10.1271/bbb1961.54.1599

PubMed ID: 3595538

Title: Identification, characterization, and regulation of a rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I.

PubMed ID: 3595538

DOI: 10.1210/endo-121-2-684

PubMed ID: 2538424

Title: Primary structure of rat insulin-like growth factor-I and its biological activities.

PubMed ID: 2538424

DOI: 10.1016/s0021-9258(18)83592-x

Sequence Information:

Length: 153
Mass: 17079
Checksum: 966F3C0FA4EB3DE7
Sequence:

MGKISSLPTQ LFKICLCDFL KIKIHIMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD 
ALQFVCGPRG FYFNKPTGYG SSIRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPTKSARS 
IRAQRHTDMP KTQKEVHLKN TSRGSAGNKT YRM

Genular Protein ID: 445719452

Symbol: A0A0G2JX40_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0G2JX40

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 143
Mass: 16075
Checksum: 1726EFEA371D8D67
Sequence:

MSAPPIKIHI MSSSHLFYLA LCLLTFTSSA TAGPETLCGA ELVDALQFVC GPRGFYFNKP 
TGYGSSIRRA PQTGIVDECC FRSCDLRRLE MYCAPLKPTK SARSIRAQRH TDMPKTQKSQ 
PLSTHKKRKL QRRRKGSTLE EHK

Genular Protein ID: 2910449481

Symbol: F8WFZ5_RAT

Name: N/A

UniProtKB Accession Codes:

F8WFZ5

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 159
Mass: 17959
Checksum: CEA7ECE1968BA152
Sequence:

MGKISSLPTQ LFKICLCDFL KIKIHIMSSS HLFYLALCLL TFTSSATAGP ETLCGAELVD 
ALQFVCGPRG FYFNKPTGYG SSIRRAPQTG IVDECCFRSC DLRRLEMYCA PLKPTKSARS 
IRAQRHTDMP KTQKSQPLST HKKRKLQRRR KGSTLEEHK

Genular Protein ID: 3211866384

Symbol: Q63261_RAT

Name: N/A

UniProtKB Accession Codes:

Q63261

Database IDs:

Citations:

PubMed ID: 3619921

Title: Rat IGF-I cDNA's contain multiple 5'-untranslated regions.

PubMed ID: 3619921

DOI: 10.1016/0006-291X(87)90768-6

Sequence Information:

Length: 51
Mass: 5651
Checksum: E2C64C3EAD496854
Sequence:

MLSQTPPTKQ HMFLSPGLCF HFGLIIPTLT CCVNDPGRTK MSAPPIKIHI M

Genular Protein ID: 835594943

Symbol: Q5RK13_RAT

Name: N/A

UniProtKB Accession Codes:

Q5RK13

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 127
Mass: 14106
Checksum: 104E126BCFCA5CB7
Sequence:

MSSSHLFYLA LCLLTFTSSA TAGPETLCGA ELVDALQFVC GPRGFYFNKP TGYGSSIRRA 
PQTGIVDECC FRSCDLRRLE MYCAPLKPTK SARSIRAQRH TDMPKTQKEV HLKNTSRGSA 
GNKTYRM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Igf1

Associated with

Other Information

Mosaic evolution of the insulin-like growth factors. Organization, sequence, and expression of the rat insulin-like growth factor I gene. PubMed ID: 3034909

Isolation of rat testis cDNAs encoding an insulin-like growth factor I precursor. PubMed ID: 3652906

Molecular cloning of rat insulin-like growth factor I complementary deoxyribonucleic acids: differential messenger ribonucleic acid processing and regulation by growth hormone in extrahepatic tissues. PubMed ID: 3453891

Sequence of two rat insulin-like growth factor I mRNAs differing within the 5' untranslated region. PubMed ID: 3658684

A new cDNA clone relating to larger molecular species of rat insulin-like growth factor-I mRNA. PubMed ID: 1368571

Identification, characterization, and regulation of a rat complementary deoxyribonucleic acid which encodes insulin-like growth factor-I. PubMed ID: 3595538

Primary structure of rat insulin-like growth factor-I and its biological activities. PubMed ID: 2538424

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Rat IGF-I cDNA's contain multiple 5'-untranslated regions. PubMed ID: 3619921

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gene and alternative splicing annotation with AIR. PubMed ID: 15632090

Database document:

PubMed ID: 3034909

PubMed ID: 3652906

PubMed ID: 3453891

PubMed ID: 3658684

PubMed ID: 1368571

PubMed ID: 3595538

PubMed ID: 2538424

PubMed ID: 15057822

PubMed ID: 15057822

PubMed ID: 3619921

PubMed ID: 15489334

PubMed ID: 15632090