Details for: Igf2

Gene ID: 24483

Symbol: Igf2

Description: insulin-like growth factor 2

Associated with

  • Animal organ morphogenesis
    (GO:0009887)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Embryonic placenta development
    (GO:0001892)
  • Embryonic placenta morphogenesis
    (GO:0060669)
  • Exocrine pancreas development
    (GO:0031017)
  • Extracellular space
    (GO:0005615)
  • Female pregnancy
    (GO:0007565)
  • Glucose metabolic process
    (GO:0006006)
  • Growth factor activity
    (GO:0008083)
  • Hormone activity
    (GO:0005179)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin-like growth factor receptor signaling pathway
    (GO:0048009)
  • Insulin receptor binding
    (GO:0005158)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Integrin binding
    (GO:0005178)
  • In utero embryonic development
    (GO:0001701)
  • Memory
    (GO:0007613)
  • Negative regulation of muscle cell differentiation
    (GO:0051148)
  • Negative regulation of natural killer cell mediated cytotoxicity
    (GO:0045953)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Ossification
    (GO:0001503)
  • Osteoblast differentiation
    (GO:0001649)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cell division
    (GO:0051781)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of organ growth
    (GO:0046622)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of skeletal muscle tissue growth
    (GO:0048633)
  • Positive regulation of steroid hormone biosynthetic process
    (GO:0090031)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Protein binding
    (GO:0005515)
  • Protein serine/threonine kinase activator activity
    (GO:0043539)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of muscle cell differentiation
    (GO:0051147)
  • Response to estradiol
    (GO:0032355)
  • Response to ethanol
    (GO:0045471)
  • Response to nicotine
    (GO:0035094)
  • Response to nutrient levels
    (GO:0031667)
  • Response to organic cyclic compound
    (GO:0014070)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Signal transduction
    (GO:0007165)
  • Spongiotrophoblast cell proliferation
    (GO:0060720)
  • Striated muscle cell differentiation
    (GO:0051146)
  • Transmembrane receptor protein tyrosine kinase activator activity
    (GO:0030297)

Other Information

Genular Protein ID: 2831693744

Symbol: IGF2_RAT

Name: Insulin-like growth factor II

UniProtKB Accession Codes:

P01346

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 EMBL 14 ExpressionAtlas 1 GO 50 Gene3D 1 Genevisible 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 5 RefSeq 4 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 6382022

Title: Insulin-like growth factor II precursor gene organization in relation to insulin gene family.

PubMed ID: 6382022

DOI: 10.1038/310777a0

PubMed ID: 3889836

Title: Developmental and tissue-specific expression of a family of transcripts related to rat insulin-like growth factor II mRNA.

PubMed ID: 3889836

DOI: 10.1093/nar/13.4.1119

PubMed ID: 2438416

Title: Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family.

PubMed ID: 2438416

DOI: 10.1016/0022-2836(86)90025-2

PubMed ID: 3023383

Title: Structure and expression of the rat insulin-like growth factor II (rIGF-II) gene. rIGF-II RNAs are transcribed from two promoters.

PubMed ID: 3023383

DOI: 10.1016/s0021-9258(19)76010-4

PubMed ID: 3167060

Title: Transcriptional deviation of the rat insulin-like growth factor II gene initiated at three alternative leader-exons between neonatal tissues and ascites hepatomas.

PubMed ID: 3167060

DOI: 10.1016/0167-4781(88)90138-8

PubMed ID: 6390212

Title: Isolation of a cDNA clone encoding rat insulin-like growth factor-II precursor.

PubMed ID: 6390212

DOI: 10.1038/312277a0

PubMed ID: 3221878

Title: Structure of the rat insulin-like growth factor II transcriptional unit: heterogeneous transcripts are generated from two promoters by use of multiple polyadenylation sites and differential ribonucleic acid splicing.

PubMed ID: 3221878

DOI: 10.1210/mend-2-11-1115

PubMed ID: 7016879

Title: Purification and primary structure of a polypeptide with multiplication-stimulating activity from rat liver cell cultures. Homology with human insulin-like growth factor II.

PubMed ID: 7016879

DOI: 10.1016/s0021-9258(19)69071-x

PubMed ID: 16912056

Title: Preptin, another peptide product of the pancreatic beta-cell, is osteogenic in vitro and in vivo.

PubMed ID: 16912056

DOI: 10.1152/ajpendo.00642.2005

Sequence Information:

  • Length: 180
  • Mass: 20086
  • Checksum: AF12B4EEC0DBCC34
  • Sequence:
    • MGIPVGKSML VLLISLAFAL CCIAAYRPSE TLCGGELVDT LQFVCSDRGF YFSRPSSRAN 
RRSRGIVEEC CFRSCDLALL ETYCATPAKS ERDVSTSQAV LPDDFPRYPV GKFFKFDTWR 
QSAGRLRRGL PALLRARRGR MLAKELEAFR EAKRHRPLIV LPPKDPAHGG ASSEMSSNHQ

Genular Protein ID: 3968723762

Symbol: A6HY76_RAT

Name: N/A

UniProtKB Accession Codes:

A6HY76

Database IDs:

ARBA 10 CDD 1 CTD 1 EMBL 2 GO 5 Gene3D 1 InterPro 7 NCBI Taxonomy 1 PANTHER 2 PIRSR 1 PRINTS 3 PROSITE 1 Pfam 2 Proteomes 1 RGD 2 RefSeq 1 RuleBase 1 SAM 2 SMART 2 SUPFAM 1

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

  • Length: 191
  • Mass: 21117
  • Checksum: 4297C053AF5FD96E
  • Sequence:
    • MGGSVAGFQV PMGIPVGKSM LVLLISLAFA LCCIAAYRPS ETLCGGELVD TLQFVCSDRG 
FYFSRPSSRA NRRSRGIVEE CCFRSCDLAL LETYCATPAK SERDVSTSQA VLPDDFPRYP 
VGKFFKFDTW RQSAGRLRRG LPALLRARRG RMLAKELEAF REAKRHRPLI VLPPKDPAHG 
GASSEMSSNH Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.