Genular: Defining Cellular Identity and Function

Details for: Il6

Gene ID: 24498

Symbol: Il6

Ensembl ID: ENSRNOG00000010278

Description: interleukin 6

Associated with

Cytokine signaling in immune system
(R-RNO-1280215)
Immune system
(R-RNO-168256)
Interleukin-6 family signaling
(R-RNO-6783589)
Interleukin-6 signaling
(R-RNO-1059683)
Mapk1 (erk2) activation
(R-RNO-112411)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk3 (erk1) activation
(R-RNO-110056)
Mapk family signaling cascades
(R-RNO-5683057)
Metabolism of proteins
(R-RNO-392499)
Post-translational protein modification
(R-RNO-597592)
Post-translational protein phosphorylation
(R-RNO-8957275)
Raf-independent mapk1/3 activation
(R-RNO-112409)
Regulation of insulin-like growth factor (igf) transport and uptake by insulin-like growth factor binding proteins (igfbps)
(R-RNO-381426)
Signaling by interleukins
(R-RNO-449147)
Acute-phase response
(GO:0006953)
Cell redox homeostasis
(GO:0045454)
Cellular response to hepatocyte growth factor stimulus
(GO:0035729)
Cellular response to nutrient levels
(GO:0031669)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine activity
(GO:0005125)
Defense response to protozoan
(GO:0042832)
Endocrine pancreas development
(GO:0031018)
Gene expression
(GO:0010467)
Germinal center b cell differentiation
(GO:0002314)
Glucose homeostasis
(GO:0042593)
Growth factor activity
(GO:0008083)
Hepatic immune response
(GO:0002384)
Inflammatory response
(GO:0006954)
Interleukin-6 receptor binding
(GO:0005138)
Lymphocyte costimulation
(GO:0031294)
Myeloid cell homeostasis
(GO:0002262)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of bone resorption
(GO:0045779)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of chemokine production
(GO:0032682)
Negative regulation of collagen biosynthetic process
(GO:0032966)
Negative regulation of gluconeogenesis
(GO:0045721)
Negative regulation of membrane potential
(GO:0045837)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neuron projection development
(GO:0031175)
Neutrophil apoptotic process
(GO:0001781)
Positive regulation of acute inflammatory response
(GO:0002675)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of epithelial to mesenchymal transition
(GO:0010718)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of gliogenesis
(GO:0014015)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of interleukin-1 beta production
(GO:0032731)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of interleukin-10 production
(GO:0032733)
Positive regulation of interleukin-17 production
(GO:0032740)
Positive regulation of interleukin-21 production
(GO:0032745)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein import into nucleus
(GO:0042307)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of t-helper 2 cell differentiation
(GO:0045630)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of translation
(GO:0045727)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Positive regulation of vascular endothelial growth factor production
(GO:0010575)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cell shape
(GO:0008360)
Regulation of circadian sleep/wake cycle, non-rem sleep
(GO:0045188)
Regulation of vascular endothelial growth factor production
(GO:0010574)
Response to activity
(GO:0014823)
Response to amino acid
(GO:0043200)
Response to auditory stimulus
(GO:0010996)
Response to bacterium
(GO:0009617)
Response to caffeine
(GO:0031000)
Response to cytokine
(GO:0034097)
Response to insulin
(GO:0032868)
Response to lipopolysaccharide
(GO:0032496)
Response to mechanical stimulus
(GO:0009612)
Response to nutrient levels
(GO:0031667)
Response to organic cyclic compound
(GO:0014070)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
Response to yeast
(GO:0001878)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
T-helper 2 cell differentiation
(GO:0045064)
T cell activation
(GO:0042110)
Vascular endothelial growth factor production
(GO:0010573)

Other Information

Proteins

IL6_RAT

Genular Protein ID: 530533800

Symbol: IL6_RAT

Name: N/A

UniProtKB Accession Codes:

P20607

Database IDs:

Citations:

PubMed ID: 2789217

Title: Structure of the rat interleukin 6 gene and its expression in macrophage-derived cells.

PubMed ID: 2789217

DOI: 10.1016/s0021-9258(18)71589-5

PubMed ID: 23955712

Title: Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocannabinoids mediates beta cell loss in type 2 diabetes.

PubMed ID: 23955712

DOI: 10.1038/nm.3265

Sequence Information:

Length: 211
Mass: 24357
Checksum: 17D248A14F96B5C1
Sequence:

MKFLSARDFQ PVAFLGLMLL TATAFPTSQV RRGDFTEDTT HNRPVYTTSQ VGGLITYVLR 
EILEMRKELC NGNSDCMNSD DALSENNLKL PEIQRNDGCF QTGYNQEICL LKICSGLLEF 
RFYLEFVKNN LQDNKKDKAR VIQSNTETLV HIFKQEIKDS YKIVLPTPTS NALLMEKLES 
QKEWLRTKTI QLILKALEEF LKVTMRSTRQ T

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.