Details for: Ins2

Gene ID: 24506

Symbol: Ins2

Ensembl ID: ENSRNOG00000020405

Description: insulin 2

Associated with

  • Acute-phase response
    (GO:0006953)
  • Alpha-beta t cell activation
    (GO:0046631)
  • Biological_process
    (GO:0008150)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Er overload response
    (GO:0006983)
  • Extracellular space
    (GO:0005615)
  • Fatty acid homeostasis
    (GO:0055089)
  • Glucose homeostasis
    (GO:0042593)
  • Glucose metabolic process
    (GO:0006006)
  • Glycoprotein biosynthetic process
    (GO:0009101)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Hormone activity
    (GO:0005179)
  • Identical protein binding
    (GO:0042802)
  • Insulin-like growth factor receptor binding
    (GO:0005159)
  • Insulin processing
    (GO:0030070)
  • Insulin receptor binding
    (GO:0005158)
  • Insulin receptor signaling pathway
    (GO:0008286)
  • Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
    (GO:0070059)
  • Lactate biosynthetic process
    (GO:0019249)
  • Lipid biosynthetic process
    (GO:0008610)
  • Lipid catabolic process
    (GO:0016042)
  • Lipoprotein biosynthetic process
    (GO:0042158)
  • Myoblast fusion
    (GO:0007520)
  • Myotube differentiation
    (GO:0014902)
  • Negative regulation of acute inflammatory response
    (GO:0002674)
  • Negative regulation of fatty acid metabolic process
    (GO:0045922)
  • Negative regulation of feeding behavior
    (GO:2000252)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of glycogen catabolic process
    (GO:0045818)
  • Negative regulation of lipid catabolic process
    (GO:0050995)
  • Negative regulation of protein catabolic process
    (GO:0042177)
  • Negative regulation of protein secretion
    (GO:0050709)
  • Negative regulation of proteolysis
    (GO:0045861)
  • Negative regulation of reactive oxygen species biosynthetic process
    (GO:1903427)
  • Negative regulation of respiratory burst involved in inflammatory response
    (GO:0060266)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Neuron projection maintenance
    (GO:1990535)
  • Nitric oxide-cgmp-mediated signaling pathway
    (GO:0038060)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of dendritic spine maintenance
    (GO:1902952)
  • Positive regulation of dna replication
    (GO:0045740)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of fatty acid biosynthetic process
    (GO:0045723)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of glucose metabolic process
    (GO:0010907)
  • Positive regulation of glycogen biosynthetic process
    (GO:0045725)
  • Positive regulation of glycolytic process
    (GO:0045821)
  • Positive regulation of insulin receptor signaling pathway
    (GO:0046628)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of mitotic nuclear division
    (GO:0045840)
  • Positive regulation of nitric oxide mediated signal transduction
    (GO:0010750)
  • Positive regulation of peptidyl-tyrosine phosphorylation
    (GO:0050731)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein autophosphorylation
    (GO:0031954)
  • Positive regulation of protein localization to nucleus
    (GO:1900182)
  • Positive regulation of protein metabolic process
    (GO:0051247)
  • Positive regulation of protein secretion
    (GO:0050714)
  • Positive regulation of respiratory burst
    (GO:0060267)
  • Protease binding
    (GO:0002020)
  • Protein hexamerization
    (GO:0034214)
  • Receptor internalization
    (GO:0031623)
  • Regulation of cellular amino acid metabolic process
    (GO:0006521)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of phosphorylation
    (GO:0042325)
  • Regulation of protein localization
    (GO:0032880)
  • Regulation of protein localization to plasma membrane
    (GO:1903076)
  • Regulation of protein secretion
    (GO:0050708)
  • Secretory granule
    (GO:0030141)
  • Sno(s)rna-containing ribonucleoprotein complex
    (GO:0005732)
  • Vasodilation
    (GO:0042311)
  • Wound healing
    (GO:0042060)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 2373248301

Symbol: INS2_RAT

Name: Insulin-2

UniProtKB Accession Codes:

P01323

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BioGRID 1 CDD 1 CTD 1 EMBL 4 Ensembl 4 GO 66 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 9 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UniProtKB 1 eggNOG 1

Citations:

PubMed ID: 498284

Title: The structure and evolution of the two nonallelic rat preproinsulin genes.

PubMed ID: 498284

DOI: 10.1016/0092-8674(79)90071-0

PubMed ID: 2427930

Title: RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon.

PubMed ID: 2427930

DOI: 10.1128/mcb.5.8.2090-2103.1985

PubMed ID: 6249167

Title: The structure of rat preproinsulin genes.

PubMed ID: 6249167

DOI: 10.1111/j.1749-6632.1980.tb47271.x

PubMed ID: 4311938

Title: Proinsulin and the biosynthesis of insulin.

PubMed ID: 4311938

DOI: 10.1016/b978-0-12-571125-8.50008-9

PubMed ID: 4640931

Title: Primary structures of the proinsulin connecting peptides of the rat and the horse.

PubMed ID: 4640931

DOI: 10.1016/s0021-9258(20)81791-8

PubMed ID: 4554104

Title: Rat-proinsulin C-peptides. Amino-acid sequences.

PubMed ID: 4554104

DOI: 10.1111/j.1432-1033.1972.tb01680.x

Sequence Information:

  • Length: 110
  • Mass: 12339
  • Checksum: 3A626DA98C86F3CA
  • Sequence:
    • MALWIRFLPL LALLILWEPR PAQAFVKQHL CGSHLVEALY LVCGERGFFY TPMSRREVED 
PQVAQLELGG GPGAGDLQTL ALEVARQKRG IVDQCCTSIC SLYQLENYCN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.