Genular: Defining Cellular Identity and Function

Details for: Jak2

Gene ID: 24514

Symbol: Jak2

Ensembl ID: ENSRNOG00000059968

Description: Janus kinase 2

Associated with

Cell cycle
(R-RNO-1640170)
Cell cycle, mitotic
(R-RNO-69278)
Cyclin d associated events in g1
(R-RNO-69231)
Cytokine signaling in immune system
(R-RNO-1280215)
Erythropoietin activates phosphoinositide-3-kinase (pi3k)
(R-RNO-9027276)
Erythropoietin activates ras
(R-RNO-9027284)
Factors involved in megakaryocyte development and platelet production
(R-RNO-983231)
G1 phase
(R-RNO-69236)
Growth hormone receptor signaling
(R-RNO-982772)
Hemostasis
(R-RNO-109582)
Ifng signaling activates mapks
(R-RNO-9732724)
Il-6-type cytokine receptor ligand interactions
(R-RNO-6788467)
Immune system
(R-RNO-168256)
Inactivation of csf3 (g-csf) signaling
(R-RNO-9705462)
Interferon gamma signaling
(R-RNO-877300)
Interferon signaling
(R-RNO-913531)
Interleukin-2 family signaling
(R-RNO-451927)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-RNO-512988)
Interleukin-4 and interleukin-13 signaling
(R-RNO-6785807)
Interleukin-6 family signaling
(R-RNO-6783589)
Interleukin-6 signaling
(R-RNO-1059683)
Interleukin-12 family signaling
(R-RNO-447115)
Interleukin-12 signaling
(R-RNO-9020591)
Interleukin-20 family signaling
(R-RNO-8854691)
Interleukin-23 signaling
(R-RNO-9020933)
Interleukin-27 signaling
(R-RNO-9020956)
Interleukin-35 signalling
(R-RNO-8984722)
Interleukin receptor shc signaling
(R-RNO-912526)
Mapk1 (erk2) activation
(R-RNO-112411)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk3 (erk1) activation
(R-RNO-110056)
Mapk family signaling cascades
(R-RNO-5683057)
Mitotic g1 phase and g1/s transition
(R-RNO-453279)
Prolactin receptor signaling
(R-RNO-1170546)
Raf-independent mapk1/3 activation
(R-RNO-112409)
Raf/map kinase cascade
(R-RNO-5673001)
Raf activation
(R-RNO-5673000)
Regulation of ifng signaling
(R-RNO-877312)
Signaling by csf3 (g-csf)
(R-RNO-9674555)
Signaling by erythropoietin
(R-RNO-9006335)
Signaling by interleukins
(R-RNO-449147)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signaling by scf-kit
(R-RNO-1433557)
Acetylcholine receptor binding
(GO:0033130)
Adaptive immune response
(GO:0002250)
Atp binding
(GO:0005524)
Axon regeneration
(GO:0031103)
Cell differentiation
(GO:0030154)
Chromatin organization
(GO:0006325)
Chromatin remodeling
(GO:0006338)
Cytokine-mediated signaling pathway
(GO:0019221)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
Erythrocyte differentiation
(GO:0030218)
G protein-coupled receptor signaling pathway
(GO:0007186)
Growth hormone receptor binding
(GO:0005131)
Heme binding
(GO:0020037)
Histone binding
(GO:0042393)
Histone h3y41 kinase activity
(GO:0035401)
Hormone-mediated signaling pathway
(GO:0009755)
Identical protein binding
(GO:0042802)
Insulin receptor substrate binding
(GO:0043560)
Interleukin-12 receptor binding
(GO:0005143)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Metal ion binding
(GO:0046872)
Microglial cell activation
(GO:0001774)
Mineralocorticoid receptor signaling pathway
(GO:0031959)
Myeloid cell differentiation
(GO:0030099)
Negative regulation of cardiac muscle cell apoptotic process
(GO:0010667)
Negative regulation of cell-cell adhesion
(GO:0022408)
Negative regulation of cell population proliferation
(GO:0008285)
Non-membrane spanning protein tyrosine kinase activity
(GO:0004715)
Peptide hormone receptor binding
(GO:0051428)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphorylation
(GO:0016310)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of platelet activation
(GO:0010572)
Positive regulation of type ii interferon production
(GO:0032729)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein tyrosine kinase activity
(GO:0004713)
Receptor signaling pathway via jak-stat
(GO:0007259)
Response to amine
(GO:0014075)
Response to lipopolysaccharide
(GO:0032496)
Response to organic cyclic compound
(GO:0014070)
Response to oxidative stress
(GO:0006979)
Sh2 domain binding
(GO:0042169)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Transcription by rna polymerase ii
(GO:0006366)
Type 1 angiotensin receptor binding
(GO:0031702)
Tyrosine phosphorylation of stat protein
(GO:0007260)

Other Information

Proteins

Janus kinase 2

Genular Protein ID: 2146739451

Symbol: JAK2_RAT

Name: Janus kinase 2

UniProtKB Accession Codes:

Q62689

Database IDs:

Citations:

PubMed ID: 7607555

Title: Cloning of the gene encoding rat JAK2, a protein tyrosine kinase.

PubMed ID: 7607555

DOI: 10.1016/0378-1119(95)00041-4

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1132
Mass: 130585
Checksum: C3AEDF2FECE8B95A
Sequence:

MGMACLTMTE MEGTSTSPAH QNGDIPGNAN SVKQTEPVLQ VYLYHSLGQA EGDYLKFPNG 
EYVAEEICVA ASKACGITPV YHNMFALMSE TERIWYPPNH VFHIDESTRH NILYRIRFYF 
PHWYCSGSNR TYRYGVSRGA EAPLLDDFVM SYLFAQWRHD FVHGWIKVPV THETQEECLG 
MAVLDMMRIA KEKDQTPLAV YNSISYKTFL PKCVRAKIQD YHILTRKRIR YRFRRFIQQF 
SQCKATARNL KLKYLINLET LQSAFYTEQF EVKESARGPS GEEIFATIII TGNGGIQWSR 
GKHKESETLT EQDLQLYCDF PDIIDVSIKQ ANQECSTESR VVTVHKQDGK VLEIELSSLK 
EALSFVSLID GYYRLTADAH HYLCKEVAPP AVLENIHSNC HGPISMDFAI SKLKKAGNQT 
GLYVLRCSPK DFNKYFLTFA VERENVIEYK HCLITKNENG EYNLSGTKRN FSSLKDLLNC 
YQMETVRSDS IIFQFTKCCP PKPKDKSNLL VFRTNGVSDV QLSPTLQRHN NVNQMVFHKI 
RNEDLIFNES LGQGTFTKIF KGVRREVGDY GQLHETEVLL KVLDKAHRNY SESFFEAASM 
MSQLSHKHLV LNYGVCVCGE ENILVQEFVK FGSLDTYLKK NKNSINILWK LGVAKQLAWA 
MHFLEEKSLI HGNVCAKNIL LIREEDRKTG NPPFIKLSDP GISITVLPKD ILQERIPWVP 
PECIENPKNL TLATDKWSFG TTLWEICSGG DKPLSALDSQ RKLQFYEDKH QLPAPKWTEL 
ANLINTCMDY EPDFRPAFRA VIRDLNSLFT PDYELLTEND MLPNMRIGAL GFSGAFEDRD 
PTQFEERHLK FLQQLGKGNF GSVEMCRYDP LQDNTGEVVA VKKLQHSTEE HLRDFEREIE 
ILKSLQHDNI VKYKGVCYSA GRRNLRLIME YLPYGSLRDY LQKHKERIDH KKLLQYTSQI 
CKGMEYLGTK RYIHRDLATR NILVENENRV KIGDFGLTKV LPQDKEYYKV KEPGESPIFW 
YAPESLTESK FSVASDVWSF GVVLYELFTY IEKSKSPPVE FMRMIGNDKQ GQMIVFHLIE 
LLKNNGRLPR PEGCPDEIYV IMTECWNNNV NQRPSFRDLS LRVDQIRDSM AA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.