Genular: Defining Cellular Identity and Function

Details for: Jun

Gene ID: 24516

Symbol: Jun

Ensembl ID: ENSRNOG00000026293

Description: Jun proto-oncogene, AP-1 transcription factor subunit

Associated with

Activation of the ap-1 family of transcription factors
(R-RNO-450341)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular senescence
(R-RNO-2559583)
Cytokine signaling in immune system
(R-RNO-1280215)
Esr-mediated signaling
(R-RNO-8939211)
Estrogen-dependent gene expression
(R-RNO-9018519)
Fc epsilon receptor (fceri) signaling
(R-RNO-2454202)
Fceri mediated mapk activation
(R-RNO-2871796)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Interleukin-17 signaling
(R-RNO-448424)
Map kinase activation
(R-RNO-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-RNO-450282)
Myd88 cascade initiated on plasma membrane
(R-RNO-975871)
Myd88 dependent cascade initiated on endosome
(R-RNO-975155)
Myd88-independent tlr4 cascade
(R-RNO-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-RNO-166058)
Oxidative stress induced senescence
(R-RNO-2559580)
Signaling by interleukins
(R-RNO-449147)
Signaling by nuclear receptors
(R-RNO-9006931)
Signal transduction
(R-RNO-162582)
Toll-like receptor cascades
(R-RNO-168898)
Toll like receptor 2 (tlr2) cascade
(R-RNO-181438)
Toll like receptor 3 (tlr3) cascade
(R-RNO-168164)
Toll like receptor 4 (tlr4) cascade
(R-RNO-166016)
Toll like receptor 5 (tlr5) cascade
(R-RNO-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-RNO-168181)
Toll like receptor 9 (tlr9) cascade
(R-RNO-168138)
Toll like receptor 10 (tlr10) cascade
(R-RNO-168142)
Toll like receptor tlr1:tlr2 cascade
(R-RNO-168179)
Toll like receptor tlr6:tlr2 cascade
(R-RNO-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-RNO-975138)
Trif(ticam1)-mediated tlr4 signaling
(R-RNO-937061)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Axon regeneration
(GO:0031103)
Camp response element binding
(GO:0035497)
Cell population proliferation
(GO:0008283)
Cellular response to reactive oxygen species
(GO:0034614)
Cellular response to zinc ion starvation
(GO:0034224)
Chromatin binding
(GO:0003682)
Circadian rhythm
(GO:0007623)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna-templated transcription
(GO:0006351)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Enzyme binding
(GO:0019899)
General transcription initiation factor binding
(GO:0140296)
Gtpase activator activity
(GO:0005096)
Hmg box domain binding
(GO:0071837)
Identical protein binding
(GO:0042802)
Immune response
(GO:0006955)
Learning
(GO:0007612)
Liver development
(GO:0001889)
Microglial cell activation
(GO:0001774)
Monocyte differentiation
(GO:0030224)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of protein autophosphorylation
(GO:0031953)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Outflow tract morphogenesis
(GO:0003151)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell migration
(GO:0010634)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
R-smad binding
(GO:0070412)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Release from viral latency
(GO:0019046)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cytokine
(GO:0034097)
Response to insulin
(GO:0032868)
Response to lipopolysaccharide
(GO:0032496)
Response to mechanical stimulus
(GO:0009612)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to xenobiotic stimulus
(GO:0009410)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription factor binding
(GO:0008134)
Transforming growth factor beta receptor signaling pathway
(GO:0007179)
Ubiquitin-like protein ligase binding
(GO:0044389)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Activator protein 1

Genular Protein ID: 1894468189

Symbol: JUN_RAT

Name: Activator protein 1

UniProtKB Accession Codes:

P17325

Database IDs:

Citations:

PubMed ID: 2507134

Title: Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis.

PubMed ID: 2507134

PubMed ID: 2113275

Title: Nucleotide sequence of rat c-jun protooncogene.

PubMed ID: 2113275

DOI: 10.1093/nar/18.11.3400

PubMed ID: 1310930

Title: Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells.

PubMed ID: 1310930

DOI: 10.1002/j.1460-2075.1992.tb05039.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9154808

Title: Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.

PubMed ID: 9154808

DOI: 10.1128/mcb.17.6.3094

PubMed ID: 20852630

Title: Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.

PubMed ID: 20852630

DOI: 10.1038/ncb2098

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 27458189

Title: Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity.

PubMed ID: 27458189

DOI: 10.15252/embj.201593070

Sequence Information:

Length: 334
Mass: 36001
Checksum: AFD9DF7D7C791B58
Sequence:

MTAKMETTFY DDALNASFLQ SESGAYGYSN PKILKQSMTL NLADPVGNLK PHLRAKNSDL 
LTSPDVGLLK LASPELERLI IQSSNGHITT TPTPTQFLCP KNVTDEQEGF AEGFVRALAE 
LHSQNTLPSV TSAAQPVSGA GMVAPAVASV AGAGGGGGYS ASLHSEPPVY ANLSNFNPGA 
LSSGGGAPSY GATGLAFPSQ PQQQQQPPQP PHHLPQQIPV QHPRLQALKE EPQTVPEMPG 
ETPPLSPIDM ESQERIKAER KRMRNRIAAS KCRKRKLERI ARLEEKVKTL KAQNSELAST 
ANMLREQVAQ LKQKVMNHVN SGCQLMLTQQ LQTF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Jun

Associated with

Other Information

Structure and expression of the rat c-jun messenger RNA: tissue distribution and increase during chemical hepatocarcinogenesis. PubMed ID: 2507134

Nucleotide sequence of rat c-jun protooncogene. PubMed ID: 2113275

Transcriptional regulation of the c-jun gene by retinoic acid and E1A during differentiation of F9 cells. PubMed ID: 1310930

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions. PubMed ID: 9154808

Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation. PubMed ID: 20852630

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. PubMed ID: 27458189