Genular: Defining Cellular Identity and Function

Details for: Kras

Gene ID: 24525

Symbol: Kras

Description: KRAS proto-oncogene, GTPase

Associated with

Actin cytoskeleton organization
(GO:0030036)
Cardiac muscle cell proliferation
(GO:0060038)
Cell population proliferation
(GO:0008283)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Endomembrane system
(GO:0012505)
Epithelial tube branching involved in lung morphogenesis
(GO:0060441)
Female pregnancy
(GO:0007565)
Forebrain astrocyte development
(GO:0021897)
Gdp binding
(GO:0019003)
Gene expression
(GO:0010467)
Glial cell proliferation
(GO:0014009)
Gmp binding
(GO:0019002)
Golgi membrane
(GO:0000139)
G protein activity
(GO:0003925)
Gtpase activity
(GO:0003924)
Gtp binding
(GO:0005525)
Homeostasis of number of cells within a tissue
(GO:0048873)
Identical protein binding
(GO:0042802)
Liver development
(GO:0001889)
Lrr domain binding
(GO:0030275)
Membrane
(GO:0016020)
Myoblast proliferation
(GO:0051450)
Negative regulation of epithelial cell differentiation
(GO:0030857)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neuron apoptotic process
(GO:0051402)
Plasma membrane
(GO:0005886)
Positive regulation of cellular senescence
(GO:2000774)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glial cell proliferation
(GO:0060252)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of rac protein signal transduction
(GO:0035022)
Protein-containing complex binding
(GO:0044877)
Protein-membrane adaptor activity
(GO:0043495)
Protein binding
(GO:0005515)
Rac protein signal transduction
(GO:0016601)
Ras protein signal transduction
(GO:0007265)
Regulation of long-term neuronal synaptic plasticity
(GO:0048169)
Regulation of synaptic transmission, gabaergic
(GO:0032228)
Response to glucocorticoid
(GO:0051384)
Response to gravity
(GO:0009629)
Response to isolation stress
(GO:0035900)
Response to mineralocorticoid
(GO:0051385)
Signal transduction
(GO:0007165)
Skeletal muscle cell differentiation
(GO:0035914)
Striated muscle cell differentiation
(GO:0051146)
Type i pneumocyte differentiation
(GO:0060509)
Visual learning
(GO:0008542)

Other Information

Proteins

GTPase KRas
A0JN17_RAT

Genular Protein ID: 590710975

Symbol: RASK_RAT

Name: GTPase KRas

UniProtKB Accession Codes:

P08644 P46203 P97914

Database IDs:

Citations:

PubMed ID: 8058308

Title: Activation of the K-ras gene by insertion mutations in chemically induced rat renal mesenchymal tumors.

PubMed ID: 8058308

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 3023884

Title: Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.

PubMed ID: 3023884

DOI: 10.1128/mcb.6.4.1349-1351.1986

PubMed ID: 3009041

Title: Nucleotide sequence of exon I of the rat c-K-ras gene.

PubMed ID: 3009041

PubMed ID: 3110778

Title: Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors.

PubMed ID: 3110778

DOI: 10.1073/pnas.84.14.4974

PubMed ID: 12594205

Title: Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway.

PubMed ID: 12594205

DOI: 10.1074/jbc.m213214200

PubMed ID: 19319189

Title: Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.

PubMed ID: 19319189

DOI: 10.1371/journal.pone.0004884

Sequence Information:

Length: 189
Mass: 21656
Checksum: 97345422E01D2C81
Sequence:

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 
PSRTVDTKQA QELARSYGIP FIETSAKTRQ RVEDAFYTLV REIRQYRLKK ISKEEKTPGC 
VKIKKCVIM

Genular Protein ID: 259043079

Symbol: A0JN17_RAT

Name: N/A

UniProtKB Accession Codes:

A0JN17

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 188
Mass: 21495
Checksum: B0A55318AD158F51
Sequence:

MTEYKLVVVG AGGVGKSALT IQLIQNHFVD EYDPTIEDSY RKQVVIDGET CLLDILDTAG 
QEEYSAMRDQ YMRTGEGFLC VFAINNTKSF EDIHHYREQI KRVKDSEDVP MVLVGNKCDL 
PSRTVDTKQA QELARSYGIP FIETSAKTRQ GVDDAFYTLV REIRKHKEKM SKDGKKKKKK 
SRTRCIVM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Kras

Associated with

Other Information

Activation of the K-ras gene by insertion mutations in chemically induced rat renal mesenchymal tumors. PubMed ID: 8058308

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene. PubMed ID: 3023884

Nucleotide sequence of exon I of the rat c-K-ras gene. PubMed ID: 3009041

Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors. PubMed ID: 3110778

Suprachiasmatic nucleus circadian oscillatory protein, a novel binding partner of K-Ras in the membrane rafts, negatively regulates MAPK pathway. PubMed ID: 12594205

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PubMed ID: 19319189

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Gene and alternative splicing annotation with AIR. PubMed ID: 15632090