Genular: Defining Cellular Identity and Function

Details for: Lcat

Gene ID: 24530

Symbol: Lcat

Ensembl ID: ENSRNOG00000019573

Description: lecithin cholesterol acyltransferase

Associated with

Hdl remodeling
(R-RNO-8964058)
Plasma lipoprotein assembly, remodeling, and clearance
(R-RNO-174824)
Plasma lipoprotein remodeling
(R-RNO-8963899)
Transport of small molecules
(R-RNO-382551)
1-alkyl-2-acetylglycerophosphocholine esterase activity
(GO:0003847)
Aflatoxin metabolic process
(GO:0046222)
Apolipoprotein a-i binding
(GO:0034186)
Cholesterol homeostasis
(GO:0042632)
Cholesterol metabolic process
(GO:0008203)
Cholesterol transport
(GO:0030301)
Extracellular space
(GO:0005615)
High-density lipoprotein particle
(GO:0034364)
High-density lipoprotein particle remodeling
(GO:0034375)
Lipid metabolic process
(GO:0006629)
Lipoprotein biosynthetic process
(GO:0042158)
Lipoprotein metabolic process
(GO:0042157)
Phosphatidylcholine-sterol o-acyltransferase activity
(GO:0004607)
Phosphatidylcholine biosynthetic process
(GO:0006656)
Phosphatidylcholine metabolic process
(GO:0046470)
Phospholipase a2 activity
(GO:0004623)
Phospholipid metabolic process
(GO:0006644)
Platelet-activating factor acetyltransferase activity
(GO:0047179)
Regulation of high-density lipoprotein particle assembly
(GO:0090107)
Response to copper ion
(GO:0046688)
Response to glucocorticoid
(GO:0051384)
Reverse cholesterol transport
(GO:0043691)
Sterol esterase activity
(GO:0004771)
Very-low-density lipoprotein particle remodeling
(GO:0034372)

Other Information

Proteins

Phosphatidylcholine-sterol acyltransferase

Genular Protein ID: 2470429660

Symbol: LCAT_RAT

Name: Phosphatidylcholine-sterol acyltransferase

UniProtKB Accession Codes:

P18424 O35849

Database IDs:

Citations:

PubMed ID: 2402469

Title: Nucleotide sequence of the cDNA for lecithin-cholesterol acyl transferase (LCAT) from the rat.

PubMed ID: 2402469

DOI: 10.1093/nar/18.17.5308

PubMed ID: 9219904

Title: Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase.

PubMed ID: 9219904

DOI: 10.1016/s0005-2760(97)00055-6

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8820107

Title: Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates.

PubMed ID: 8820107

PubMed ID: 14636062

Title: Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains.

PubMed ID: 14636062

DOI: 10.1021/bi035460u

Sequence Information:

Length: 440
Mass: 49882
Checksum: 836BB2D589F72B63
Sequence:

MGLPGSPWQW VLLLLGLLLP PATSFWLLNV LFPPHTTPKA ELSNHTRPVI LVPGCMGNRL 
EAKLDKPNVV NWLCYRKTED FFTIWLDFNM FLPLGVDCWI DNTRVVYNRS SGHMSNAPGV 
QIRVPGFGKT YSVEYLDDNK LAGYLHTLVQ NLVNNGYVRD ETVRAAPYDW RLAPRQQDEY 
YQKLAGLVEE MYAAYGKPVF LIGHSLGCLH VLHFLLRQPQ SWKDHFIDGF ISLGAPWGGS 
IKPMRILASG DNQGIPIMSN IKLREEQRIT TTSPWMFPAH HVWPEDHVFI STPNFNYTGQ 
DFERFFADLH FEEGWHMFLQ SRDLLAGLPA PGVEVYCLYG VGMPTAHTYI YDHNFPYKDP 
VAALYEDGDD TVATRSTELC GQWQGRQSQA VHLLPMNGTD HLNMVFSNKT LEHINAILLG 
AYRHGTPKSP TASLGPPTKE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lcat

Associated with

Other Information

Nucleotide sequence of the cDNA for lecithin-cholesterol acyl transferase (LCAT) from the rat. PubMed ID: 2402469

Cloning and in vitro expression of rat lecithin:cholesterol acyltransferase. PubMed ID: 9219904

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Comparative studies on the substrate specificity of lecithin:cholesterol acyltransferase towards the molecular species of phosphatidylcholine in the plasma of 14 vertebrates. PubMed ID: 8820107