Genular: Defining Cellular Identity and Function

Details for: Lepr

Gene ID: 24536

Symbol: Lepr

Ensembl ID: ENSRNOG00000023664

Description: leptin receptor

Associated with

Angiogenesis
(GO:0001525)
Basolateral plasma membrane
(GO:0016323)
Bone growth
(GO:0098868)
Cellular response to organic substance
(GO:0071310)
Cholesterol metabolic process
(GO:0008203)
Cytokine-mediated signaling pathway
(GO:0019221)
Cytokine binding
(GO:0019955)
Cytokine receptor activity
(GO:0004896)
Eating behavior
(GO:0042755)
Energy homeostasis
(GO:0097009)
External side of plasma membrane
(GO:0009897)
Extracellular space
(GO:0005615)
Female pregnancy
(GO:0007565)
Generation of precursor metabolites and energy
(GO:0006091)
Glial cell proliferation
(GO:0014009)
Gluconeogenesis
(GO:0006094)
Glucose homeostasis
(GO:0042593)
Glycogen metabolic process
(GO:0005977)
Identical protein binding
(GO:0042802)
Lateral plasma membrane
(GO:0016328)
Leptin-mediated signaling pathway
(GO:0033210)
Leptin receptor activity
(GO:0038021)
Male gonad development
(GO:0008584)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of eating behavior
(GO:1903999)
Negative regulation of gluconeogenesis
(GO:0045721)
Negative regulation of locomotor rhythm
(GO:1904060)
Ovulation from ovarian follicle
(GO:0001542)
Peptide hormone binding
(GO:0017046)
Phagocytosis
(GO:0006909)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of insulin secretion involved in cellular response to glucose stimulus
(GO:0035774)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein-hormone receptor activity
(GO:0016500)
Receptor complex
(GO:0043235)
Regulation of bone remodeling
(GO:0046850)
Regulation of feeding behavior
(GO:0060259)
Regulation of transport
(GO:0051049)
Response to dexamethasone
(GO:0071548)
Response to estrogen
(GO:0043627)
Response to hypoxia
(GO:0001666)
Response to leptin
(GO:0044321)
Response to lipid
(GO:0033993)
Response to nicotine
(GO:0035094)
Response to nutrient
(GO:0007584)
Sexual reproduction
(GO:0019953)
T cell differentiation
(GO:0030217)

Other Information

Proteins

Leptin receptor

Genular Protein ID: 1293038997

Symbol: LEPR_RAT

Name: Leptin receptor

UniProtKB Accession Codes:

Q62959 O35772 O35773 O54805 P70493 P70494 P70495 P97589 Q62960 Q63007 Q63385 Q63386 Q9ERI4

Database IDs:

Citations:

PubMed ID: 8673096

Title: Leptin receptor missense mutation in the fatty Zucker rat.

PubMed ID: 8673096

DOI: 10.1038/ng0596-18

PubMed ID: 8702432

Title: Substitution at codon 269 (glutamine --> proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat.

PubMed ID: 8702432

DOI: 10.1006/bbrc.1996.1070

PubMed ID: 8769097

Title: Molecular cloning of rat leptin receptor isoform complementary DNAs -- identification of a missense mutation in Zucker fatty (fa/fa) rats.

PubMed ID: 8769097

DOI: 10.1006/bbrc.1996.1133

PubMed ID: 8630068

Title: Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat.

PubMed ID: 8630068

DOI: 10.1006/bbrc.1996.0691

PubMed ID: 8772180

Title: A novel leptin receptor isoform in rat.

PubMed ID: 8772180

DOI: 10.1016/0014-5793(96)00790-9

PubMed ID: 9268737

Title: Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats.

PubMed ID: 9268737

DOI: 10.1006/bbrc.1997.7159

PubMed ID: 10698121

Title: Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor.

PubMed ID: 10698121

DOI: 10.1016/s0196-9781(99)00156-4

PubMed ID: 11861497

Title: Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity.

PubMed ID: 11861497

DOI: 10.1210/endo.143.3.8669

PubMed ID: 25232147

Title: 20 years of leptin: connecting leptin signaling to biological function.

PubMed ID: 25232147

DOI: 10.1530/joe-14-0404

PubMed ID: 8690163

Title: Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr).

PubMed ID: 8690163

DOI: 10.2337/diab.45.8.1141

Sequence Information:

Length: 1162
Mass: 130833
Checksum: BA7AC2CA2D2E62AF
Sequence:

MTCQKFYVVL LHWEFLYVIT ALNLAYPTSP WRFKLFCAPP STTDDSFLSP AGVPNNTSSL 
KGASEALVEA KFNSTGIYVS ELSKTIFHCC FGNEQGQNCS ALTGNTEGKT LASVVKPLVF 
RQLGVNWDIE CWMKGDLTLF ICHMEPLLKN PFKNYDSKVH LLYDLPEVID DLPLPPLKDS 
FQTVQCNCSV RECECHVPVP RAKVNYALLM YLEITSAGVS FQSPLMSLQP MLVVKPDPPL 
GLRMEVTDDG NLKISWDSQT KAPFPLQYQV KYLENSTIVR EAAEIVSDTS LLVDSVLPGS 
SYEVQVRSKR LDGSGVWSDW SLPQLFTTQD VMYFPPKILT SVGSNASFCC IYKNENQTIS 
SKQIVWWMNL AEKIPETQYN TVSDHISKVT FSNLKATRPR GKFTYDAVYC CNEQACHHRY 
AELYVIDVNI NISCETDGYL TKMTCRWSPS TIQSLVGSTV QLRYHRRSLY CPDNPSIRPT 
SELKNCVLQT DGFYECVFQP IFLLSGYTMW IRINHSLGSL DSPPTCVLPD SVVKPLPPSN 
VKAEITINTG LLKVSWEKPV FPENNLQFQI RYGLNGKEIQ WKTHEVFDAK SKSASLPVSD 
LCAVYVVQVR CRRLDGLGYW SNWSSPAYTL VMDVKVPMRG PEFWRIMDGD ITKKERNVTL 
LWKPLMKNDS LCSVRRYVVK HRTAHNGTWS QDVGNQTNLT FLWAESAHTV TVLAINSIGA 
SLVNFNLTFS WPMSKVNAVQ SLSAYPLSSS CVILSWTLSP NDYSLLYLVI EWKNLNDDDG 
MKWLRIPSNV NKYYIHDNFI PIEKYQFSLY PVFMEGVGKP KIINGFTKDD IAKQQNDAGL 
YVIVPIIISS CVLLLGTLLI SHQRMKKLFW DDVPNPKNCS WAQGLNFQKP ETFEHLFTKH 
AESVIFGPLL LEPEPVSEEI SVDTAWKNKD EMVPAAMVSL LLTTPDSTRG SICISDQCNS 
ANFSGAQSTQ GTCEDECQSQ PSVKYATLVS NVKTVETDEE QGAIHSSVSQ CIARKHSPLR 
QSFSSNSWEI EAQAFFLLSD HPPNVISPQL SFSGLDELLE LEGNFPEENH GEKSVYYLGV 
SSGNKRENDM LLTDEAGVLC PFPAHCLFSD IRILQESCSH FVENNLNLGT SGKNFVPYMP 
QFQSCSTHSH KIIENKMCDL TV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Lepr

Associated with

Other Information

Leptin receptor missense mutation in the fatty Zucker rat. PubMed ID: 8673096

Substitution at codon 269 (glutamine --&gt; proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. PubMed ID: 8702432

Molecular cloning of rat leptin receptor isoform complementary DNAs -- identification of a missense mutation in Zucker fatty (fa/fa) rats. PubMed ID: 8769097

Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. PubMed ID: 8630068

A novel leptin receptor isoform in rat. PubMed ID: 8772180

Increase in serum leptin and uterine leptin receptor messenger RNA levels during pregnancy in rats. PubMed ID: 9268737

Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. PubMed ID: 10698121

Characterization of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. PubMed ID: 11861497

20 years of leptin: connecting leptin signaling to biological function. PubMed ID: 25232147

Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). PubMed ID: 8690163