Genular: Defining Cellular Identity and Function

Details for: Met

Gene ID: 24553

Symbol: Met

Ensembl ID: ENSRNOG00000052745

Description: MET proto-oncogene, receptor tyrosine kinase

Associated with

Axon guidance
(R-RNO-422475)
Developmental biology
(R-RNO-1266738)
Drug-mediated inhibition of met activation
(R-RNO-9734091)
Intracellular signaling by second messengers
(R-RNO-9006925)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Met activates pi3k/akt signaling
(R-RNO-8851907)
Met activates ptk2 signaling
(R-RNO-8874081)
Met activates ptpn11
(R-RNO-8865999)
Met activates rap1 and rac1
(R-RNO-8875555)
Met activates ras signaling
(R-RNO-8851805)
Met activates stat3
(R-RNO-8875791)
Met interacts with tns proteins
(R-RNO-8875513)
Met promotes cell motility
(R-RNO-8875878)
Met receptor activation
(R-RNO-6806942)
Met receptor recycling
(R-RNO-8875656)
Negative regulation of met activity
(R-RNO-6807004)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Raf/map kinase cascade
(R-RNO-5673001)
Sema4d in semaphorin signaling
(R-RNO-400685)
Sema4d mediated inhibition of cell attachment and migration
(R-RNO-416550)
Semaphorin interactions
(R-RNO-373755)
Signaling by met
(R-RNO-6806834)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Adult behavior
(GO:0030534)
Atp binding
(GO:0005524)
Beta-catenin binding
(GO:0008013)
Brain development
(GO:0007420)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Cardiac muscle cell development
(GO:0055013)
Cardiac muscle contraction
(GO:0060048)
Cell migration
(GO:0016477)
Central nervous system neuron differentiation
(GO:0021953)
Chemical synaptic transmission
(GO:0007268)
Endothelial cell morphogenesis
(GO:0001886)
Establishment of localization in cell
(GO:0051649)
Flagellated sperm motility
(GO:0030317)
Glucose homeostasis
(GO:0042593)
Hepatocyte growth factor receptor activity
(GO:0005008)
Hepatocyte growth factor receptor signaling pathway
(GO:0048012)
Identical protein binding
(GO:0042802)
Lactation
(GO:0007595)
Liver development
(GO:0001889)
Male gonad development
(GO:0008584)
Modulation of chemical synaptic transmission
(GO:0050804)
Molecular function activator activity
(GO:0140677)
Multicellular organism development
(GO:0007275)
Muscle cell migration
(GO:0014812)
Muscle organ development
(GO:0007517)
Myoblast proliferation
(GO:0051450)
Myotube differentiation
(GO:0014902)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of rho protein signal transduction
(GO:0035024)
Negative regulation of stress fiber assembly
(GO:0051497)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nervous system development
(GO:0007399)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Oligodendrocyte development
(GO:0014003)
Pancreas development
(GO:0031016)
Phagocytosis
(GO:0006909)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phospholipase binding
(GO:0043274)
Phosphorylation
(GO:0016310)
Placenta development
(GO:0001890)
Positive chemotaxis
(GO:0050918)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose transmembrane transport
(GO:0010828)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of microtubule polymerization
(GO:0031116)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein kinase activity
(GO:0004672)
Protein phosphatase binding
(GO:0019903)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of interleukin-6 production
(GO:0032675)
Response to acidic ph
(GO:0010447)
Response to organic cyclic compound
(GO:0014070)
Response to peptide hormone
(GO:0043434)
Response to xenobiotic stimulus
(GO:0009410)
Semaphorin receptor activity
(GO:0017154)
Skeletal muscle tissue development
(GO:0007519)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Hepatocyte growth factor receptor
Q2IBC7_RAT

Genular Protein ID: 312825186

Symbol: MET_RAT

Name: Hepatocyte growth factor receptor

UniProtKB Accession Codes:

P97523 P97579 Q63119 Q63964

Database IDs:

Citations:

PubMed ID: 9271668

Title: Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA.

PubMed ID: 9271668

DOI: 10.1007/s003359900533

PubMed ID: 8853431

Title: Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells.

PubMed ID: 8853431

DOI: 10.1152/ajprenal.1996.271.3.f679

PubMed ID: 8166728

Title: Increased expression of c-met messenger RNA following acute gastric injury in rats.

PubMed ID: 8166728

DOI: 10.1006/bbrc.1994.1481

PubMed ID: 7628535

Title: Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution.

PubMed ID: 7628535

DOI: 10.1006/excr.1995.1220

Sequence Information:

Length: 1382
Mass: 153941
Checksum: 66B8F2C88FE34427
Sequence:

MKAPTALAPG ILLLLLTLAQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIHNVVLPGH 
HIYLGATNYI YVLNDKDLQK VSEFKTGPVV EHPDCFPCQD CSSKANVSGG VWKDNVNMAL 
LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN AADIQSEVHC MFSPLAEEES GQCPDCVVSA 
LGAKVLLSEK DRFINFFVGN TINSSYPPDY SLHSISVRRL KETQDGFKFL TDQSYIDVLP 
EFRDSYPIKY IHAFESNHFI YFLTVQKETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI 
LTEKRRKRST REEVFNILQA AYVSKPGANL AKQIGASPYD DILYGVFAQS KPDSAEPMNR 
SAVCAFPIKY VNDFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE 
FTTALQRVDL FMGRLNHVLL TSISTFIKGD LTIANLGTSE GRFMQVVLSR TAHFTPHVNF 
LLDSYPVSPE VIVEHPSNQN GYTLVVTGKK ITKIPLNGLG CGHFQSCSQC LSPPYFIQCG 
WCHNRCVHSN ECPSGTWTQE ICLPAVYKVF PTSAPLEGGT MLTICGWDFG FKKNNKFDLR 
KTKVLLGNES CTLTLSESTT NTLKCTVGPA MSEHFNVSVI VSNSRETTQY SAFSYVDPVI 
TSISPRYGPH AGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPGHTVSAE 
FPVKLKIDLA DRVTSSFSYR EDPVVSEIHP TKSFISGGST ITGIGKNLNS VSTPKLVIEV 
HDVGVNYTVA CQHRSSSEII CCTTPSLRQL DLQLPLKTKA FFLLDGILSK HFDLTYVHDP 
MFKPFEKPVM ISMGNENVVE IKGDDIDPEA VKGEVLKVGN KSCENLHWHS EALLCTVPSD 
LLKLNGGELN IEWKQAVSST VLGKVIVQPD QNFAGLIIGA VSISVVVLLV SGLFLWLRKR 
KHKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG 
ACRQVQYLLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVPHV VIGPSSLIVH 
FNEVIGRGHF GCVYHGTLLD SDGKKIHCAV KSLNRITDIE EVSQFLTEGI IMKDFSHPNV 
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLVSKK 
FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK 
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITIYLLQG RRLLQPEYCP DALYEVMLKC 
WHPKAEMRPS VSELVSRISS IFSTFIGEHY VHVNATYVNV KCVAPYPSLL PSQDNIDGEA 
NT

Genular Protein ID: 147478429

Symbol: Q2IBC7_RAT

Name: N/A

UniProtKB Accession Codes:

Q2IBC7 A0A0G2JY19

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 1382
Mass: 153963
Checksum: 8A240A081579D9A2
Sequence:

MKAPTALAPG ILLLLLTLAQ RSHGECKEAL VKSEMNVNMK YQLPNFTAET PIHNVVLHGH 
HIYLGATNYI YVLDDKDLQK VSEFKTGPVV EHPDCFPCQD CSSKANVSGG VWKDNVNMAL 
LVDTYYDDQL ISCGSVNRGT CQRHVLPPDN AADIQSEVHC MFSPLAEEES GQCPDCVVSA 
LGAKVLLSEK DRFINFFVGN TINSSYPPDY SLHSISVRRL KETQDGFKFL TDQSYIDVLP 
EFRDSYPIKY IHAFESNHFI YFLTVQKETL DAQTFHTRII RFCSVDSGLH SYMEMPLECI 
LTEKRRKRST REEVFNILQA AYVSKPGANL AKQIGASPYD DILYGVFAQS KPDSAEPMNR 
SAVCAFPIKY VNDFFNKIVN KNNVRCLQHF YGPNHEHCFN RTLLRNSSGC EVRSDEYRTE 
FTTALQRVDL FMGRLNHVLL TSISTFIKGD LTIANLGTSE GRFMQVVLSR TAHFTPHVNF 
LLDSYPVSPE VIVEHPSNQN GYTLVVTGKK ITKIPLNGLG CGHFQSCSQC LSAPYFIQCG 
WCHNRCVHSN ECPSGTWTQE ICLPAVYKVF PTSAPLEGGT MLTICGWDFG FKKNNKFDLR 
KTKVLLGNES CTLTLSESTT NTLKCTVGPA MSEHFNVSVI VSNSRETTQY SAFSYVDPVI 
TSISPRYGPH AGGTLLTLTG KYLNSGNSRH ISIGGKTCTL KSVSDSILEC YTPGHTVSAE 
FPVKLKIDLA DRVTSSFSYR EDPVVSEIHP TKSFISGGST ITGIGKNLNS VSTPKLVIEV 
HDVGVNYTVA CQHRSSSEII CCTTPSLQQL DLQLPLKTKA FFLLDGILSK HFDLTYVHDP 
MFKPFEKPVM ISMGNENVVE IKGDDIDPEA VKGEVLKVGN KSCENLHWHS EALLCTVPSD 
LLKLNGGELN IEWKQAVSST VLGKVIVQPD QNFAGLIIGA VSISVVVLLV SGLFLWLRKR 
KHKDLGSELV RYDARVHTPH LDRLVSARSV SPTTEMVSNE SVDYRATFPE DQFPNSSQNG 
ACRQVQYPLT DLSPILTSGD SDISSPLLQN TVHIDLSALN PELVQAVQHV VIGPSSLIVH 
FNEVIGRGHF GCVYHGTLLD SDGKKIHCAV KSLNRITDIE EVSQFLTEGI IMKDFSHPNV 
LSLLGICLRS EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 
FVHRDLAARN CMLDEKFTVK VADFGLARDM YDKEYYSVHN KTGAKLPVKW MALESLQTQK 
FTTKSDVWSF GVLLWELMTR GAPPYPDVNT FDITIYLLQG RRLLQPEYCP DALYEVMLKC 
WHPKAEMRPS FSELVSRISS IFSTFIGEHY VHVNATYVNV KCVAPYPSLL PSQDNIDGEA 
NT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Met

Associated with

Other Information

Chromosomal localization of rat hepatocyte growth factor (Hgf) and HGF receptor (Met) and characterization of HGF receptor cDNA. PubMed ID: 9271668

Primary structure of rat HGF receptor and induced expression in glomerular mesangial cells. PubMed ID: 8853431

Increased expression of c-met messenger RNA following acute gastric injury in rats. PubMed ID: 8166728