Genular: Defining Cellular Identity and Function

Details for: Abcc1

Gene ID: 24565

Symbol: Abcc1

Ensembl ID: ENSRNOG00000022305

Description: ATP binding cassette subfamily C member 1

Associated with

Abc-family proteins mediated transport
(R-RNO-382556)
Arachidonic acid metabolism
(R-RNO-2142753)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular response to chemical stress
(R-RNO-9711123)
Cobalamin (cbl, vitamin b12) transport and metabolism
(R-RNO-196741)
Cytoprotection by hmox1
(R-RNO-9707564)
Drug adme
(R-RNO-9748784)
Fatty acid metabolism
(R-RNO-8978868)
Heme degradation
(R-RNO-189483)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of porphyrins
(R-RNO-189445)
Metabolism of vitamins and cofactors
(R-RNO-196854)
Metabolism of water-soluble vitamins and cofactors
(R-RNO-196849)
Paracetamol adme
(R-RNO-9753281)
Sphingolipid de novo biosynthesis
(R-RNO-1660661)
Sphingolipid metabolism
(R-RNO-428157)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-RNO-2142691)
Transport of rcbl within the body
(R-RNO-9758890)
Transport of small molecules
(R-RNO-382551)
Abc-type glutathione s-conjugate transporter activity
(GO:0015431)
Abc-type transporter activity
(GO:0140359)
Abc-type vitamin b12 transporter activity
(GO:0015420)
Abc-type xenobiotic transporter activity
(GO:0008559)
Amide transmembrane transporter activity
(GO:0042887)
Amide transport
(GO:0042886)
Apical plasma membrane
(GO:0016324)
Astrocyte differentiation
(GO:0048708)
Atpase-coupled lipid transmembrane transporter activity
(GO:0034040)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Carboxylic acid transmembrane transport
(GO:1905039)
Carboxylic acid transmembrane transporter activity
(GO:0046943)
Cell chemotaxis
(GO:0060326)
Cellular response to amyloid-beta
(GO:1904646)
Cobalamin transport
(GO:0015889)
Cyclic nucleotide transport
(GO:0070729)
Efflux transmembrane transporter activity
(GO:0015562)
Export across plasma membrane
(GO:0140115)
Glial cell differentiation
(GO:0010001)
Glutathione transmembrane transport
(GO:0034775)
Glutathione transmembrane transporter activity
(GO:0034634)
Lateral plasma membrane
(GO:0016328)
Leukotriene transport
(GO:0071716)
Long-chain fatty acid import across plasma membrane
(GO:0015911)
Long-chain fatty acid transporter activity
(GO:0005324)
Membrane
(GO:0016020)
Oxidoreductase activity
(GO:0016491)
Phospholipid efflux
(GO:0033700)
Phospholipid translocation
(GO:0045332)
Plasma membrane
(GO:0005886)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of inflammatory response
(GO:0050729)
Regulation of cellular response to drug
(GO:2001038)
Response to oxidative stress
(GO:0006979)
Response to xenobiotic stimulus
(GO:0009410)
Sphingolipid translocation
(GO:0099039)
Transepithelial transport
(GO:0070633)
Transmembrane transport
(GO:0055085)
Xenobiotic detoxification by transmembrane export across the plasma membrane
(GO:1990961)
Xenobiotic transmembrane transporter activity
(GO:0042910)
Xenobiotic transport
(GO:0042908)
Xenobiotic transport across blood-brain barrier
(GO:1990962)

Other Information

Proteins

ATP-binding cassette sub-family C member 1

Genular Protein ID: 1209944402

Symbol: MRP1_RAT

Name: ATP-binding cassette sub-family C member 1

UniProtKB Accession Codes:

Q8CG09 Q63346 Q810E4 Q810G9 Q9JHS0

Database IDs:

Citations:

PubMed ID: 12423064

Title: Cloning and characterization of the rat multidrug resistance-associated protein 1.

PubMed ID: 12423064

DOI: 10.1208/ps040315

PubMed ID: 12867490

Title: Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1).

PubMed ID: 12867490

DOI: 10.1124/dmd.31.8.1016

PubMed ID: 11208926

Title: The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress.

PubMed ID: 11208926

DOI: 10.1046/j.1471-4159.2001.00101.x

PubMed ID: 8662992

Title: cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats.

PubMed ID: 8662992

DOI: 10.1074/jbc.271.25.15091

PubMed ID: 15129170

Title: Multidrug resistance protein 1-mediated transport of saquinavir by microglia.

PubMed ID: 15129170

DOI: 10.1097/00001756-200405190-00020

PubMed ID: 17050692

Title: Role of ABCC1 in export of sphingosine-1-phosphate from mast cells.

PubMed ID: 17050692

DOI: 10.1073/pnas.0603734103

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1532
Mass: 171493
Checksum: 2E6939F63F5A3F68
Sequence:

MALSSFCSSD GSDPLWDWNV TWHTSNPDFT KCFQNTVLTW VPCFYLWSCF PLYFLYLSRH 
DRGYIQMTHL NKAKTALGFF LWIICWADLF YSFWERSQGM LLAPVLLVSP TLLGITMLLA 
TFLIQFERRK GVQSSGIMLT FWLVALLCAL AILRSKIISA LKKDAQVDMF RDSAFYLYFT 
LVFIQLVLSC FSDSSPLFSE TVRDPNPCPE SSASFLSRIT FWWITGMMVQ GYRQPLKSSD 
LWSLNKEDTS EEVVPVLVNN WKKECVKSRK QPVRIVYAPP KDPTKPKGSS QLDVNEEVEA 
LIVKSSHKDR DPSLFKVLYK TFGPYFLMSF LYKALHDLMM FAGPEILELI INFVNDREAP 
DWQGYLYTAL LFVSACLQTL ALHQYFHICF VTGMRIKTAV VGAVYRKALV ITNSARKSST 
VGEIVNLMSV DAQRFMDLAT YINMIWSAPL QVTLALYFLW LNLGPSVLAG VAVMILMVPF 
NAVMAMKTKT YQVAHMKSKD NRIKLMNEIL NGIKVLKLYA WELAFQDKVM NIRQEELKVL 
KKSAYLAAVG TFTWVCTPFL VALSTFAVFV TVDEKNILDA KKAFVSLALF NILRFPLNIL 
PMVISSIVQA SVSLKRLRIF LSHEELEPDS IERWSIKDGG GMNSITVKNA TFTWARDEPP 
TLNGITFAIP DGALVAVVGQ VGCGKSSLLS ALLAEMDKVE GHVTLKGSVA YVPQQAWIQN 
DSLRENILFG RPLQEHCYKA VMEACALLPD LEILPSGDLT EIGEKGVNLS GGQKQRVSLA 
RAVYCNSDIY LLDDPLSAVD AHVGKHIFEK VVGPMGLLKN KTRILVTHGI SYLPQVDVII 
VMSGGKISEM GSYQELLDRD GAFAEFVRTY ANTEQDLASE DDSKNGVSGL GKESKPVENG 
ILVTDAVGKP LQRHLSNSSS HSVVTNQQHS STAELQKSGV KEETWKLMEA DKAQTGQVKL 
SVYWNYMKAI GLCISFLSIF LFLCNHVSAL ASNYWLSLWT DDRPAVNGTQ ENRNFRLSVY 
GALGILQGVA VFGYSMAVSI GGIFASRRLH LDLLQNVLRS PMSFFERTPS GNLVNRFSKE 
LDTVDSMIPQ VIKMFMGSLF SVIGAVIIIL LATPIAAVII PPLGLVYFFV QRFYVASSRQ 
LKRLESVSRS PVYSHFNETL LGVSVIRAFE EQERFIRQSD LKVDENQKAY YPSIVANRWL 
AVRLECVGNC IVLFAALFAV ISRHSLSAGL VGLSVSYSLQ ITAYLNWLVR MSSEMETNIV 
AVERLKEYSE TEKEASWQIQ ETAPPSTWPH SGRVEFRDYC LRYREDLDLV LKHINVTIEG 
GEKVGIVGRT GAGKSSLTLG LFRINESAEG EIIIDGINIA KIGLHNLRFK ITIIPQDPVL 
FSGSLRMNLD PFSQYSDEEV WMALELAHLK GFVSALPDKL NHECAEGGEN LSVGQRQLVC 
LARALLRKTK ILVLDEATAA VDLETDDLIQ STIRTQFEDS TVLTIAHRLN TIMDYTRVIV 
LDKGEIRECG APSELLQQRG VFYSMAKDAG LV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Abcc1

Associated with

Other Information

Cloning and characterization of the rat multidrug resistance-associated protein 1. PubMed ID: 12423064

Molecular cloning and pharmacological characterization of rat multidrug resistance protein 1 (mrp1). PubMed ID: 12867490

The multidrug resistance protein MRP1 mediates the release of glutathione disulfide from rat astrocytes during oxidative stress. PubMed ID: 11208926

cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. PubMed ID: 8662992

Multidrug resistance protein 1-mediated transport of saquinavir by microglia. PubMed ID: 15129170

Role of ABCC1 in export of sphingosine-1-phosphate from mast cells. PubMed ID: 17050692

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903