Genular: Defining Cellular Identity and Function

Details for: Mme

Gene ID: 24590

Symbol: Mme

Ensembl ID: ENSRNOG00000009514

Description: membrane metallo-endopeptidase

Associated with

Cardiac conduction
(R-RNO-5576891)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Metabolism of angiotensinogen to angiotensins
(R-RNO-2022377)
Metabolism of proteins
(R-RNO-392499)
Muscle contraction
(R-RNO-397014)
Neutrophil degranulation
(R-RNO-6798695)
Peptide hormone metabolism
(R-RNO-2980736)
Physiological factors
(R-RNO-5578768)
Amyloid-beta clearance
(GO:0097242)
Amyloid-beta clearance by cellular catabolic process
(GO:0150094)
Amyloid-beta metabolic process
(GO:0050435)
Axon
(GO:0030424)
Bradykinin catabolic process
(GO:0010815)
Brush border
(GO:0005903)
Cardiolipin binding
(GO:1901612)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to uv-a
(GO:0071492)
Cellular response to uv-b
(GO:0071493)
Creatinine metabolic process
(GO:0046449)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Dendrite
(GO:0030425)
Early endosome
(GO:0005769)
Endopeptidase activity
(GO:0004175)
Exopeptidase activity
(GO:0008238)
Hormone catabolic process
(GO:0042447)
Kidney development
(GO:0001822)
Learning or memory
(GO:0007611)
Lung development
(GO:0030324)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metalloendopeptidase activity
(GO:0004222)
Neuronal cell body
(GO:0043025)
Neuron projection terminus
(GO:0044306)
Neuropeptide processing
(GO:0061837)
Oligopeptidase activity
(GO:0070012)
Peptidase activity
(GO:0008233)
Peptide binding
(GO:0042277)
Peptide metabolic process
(GO:0006518)
Phosphatidylserine binding
(GO:0001786)
Placenta development
(GO:0001890)
Plasma membrane
(GO:0005886)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of neurogenesis
(GO:0050769)
Presynapse
(GO:0098793)
Protein catabolic process
(GO:0030163)
Protein homodimerization activity
(GO:0042803)
Protein processing
(GO:0016485)
Proteolysis
(GO:0006508)
Replicative senescence
(GO:0090399)
Response to estrogen
(GO:0043627)
Sensory perception of pain
(GO:0019233)
Substance p catabolic process
(GO:0010814)
Synapse
(GO:0045202)
Synaptic vesicle
(GO:0008021)
Trans-golgi network
(GO:0005802)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Neprilysin

Genular Protein ID: 1920202988

Symbol: NEP_RAT

Name: Neprilysin

UniProtKB Accession Codes:

P07861

Database IDs:

Citations:

PubMed ID: 3555489

Title: Molecular cloning and amino acid sequence of rat enkephalinase.

PubMed ID: 3555489

DOI: 10.1016/s0006-291x(87)80475-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2966343

Title: Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.

PubMed ID: 2966343

DOI: 10.1016/0196-9781(88)90024-1

PubMed ID: 2703483

Title: Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant.

PubMed ID: 2703483

DOI: 10.1016/s0021-9258(18)83325-7

PubMed ID: 12835417

Title: Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity.

PubMed ID: 12835417

DOI: 10.1073/pnas.1431850100

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 750
Mass: 85795
Checksum: 609D4716C4B15CBC
Sequence:

MGRSESQMDI TDINAPKPKK KQRWTPLEIS LSVLVLLLTI IAVTMIALYA TYDDGICKSS 
DCIKSAARLI QNMDASAEPC TDFFKYACGG WLKRNVIPET SSRYSNFDIL RDELEVILKD 
VLQEPKTEDI VAVQKAKTLY RSCINESAID SRGGQPLLTL LPDIYGWPVA SQNWEQTYGT 
SWTAEKSIAQ LNSKYGKKVL INFFVGTDDK NSTQHIIHFD QPRLGLPSRD YYECTGIYKE 
ACTAYVDFMI SVARLIRQEQ RLPIDENQLS LEMNKVMELE KEIANATTKP EDRNDPMLLY 
NKMTLAKLQN NFSLEINGKP FSWSNFTNEI MSTVNINIQN EEEVVVYAPE YLTKLKPILT 
KYSPRDLQNL MSWRFIMDLV SSLSRNYKES RNAFRKALYG TTSETATWRR CANYVNGNME 
NAVGRLYVEA AFAGESKHVV EDLIAQIREV FIQTLDDLTW MDAETKKKAE EKALAIKERI 
GYPDDIISNE NKLNNEYLEL NYKEEEYFEN IIQNLKFSQS KQLKKLREKV DKDEWISGAA 
VVNAFYSSGR NQIVFPAGIL QPPFFSARQS NSLNYGGIGM VIGHEITHGF DDNGRNFNKD 
GDLVDWWTQQ SANNFKDQSQ CMVYQYGNFT WDLAGGQHLN GINTLGENIA DNGGIGQAYR 
AYQNYVKKNG EEKLLPGLDL NHKQLFFLNF AQVWCGTYRP EYAVNSIKTD VHSPGNFRII 
GTLQNSAEFA DAFHCRKNSY MNPERKCRVW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mme

Associated with

Other Information

Molecular cloning and amino acid sequence of rat enkephalinase. PubMed ID: 3555489

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney. PubMed ID: 2966343

Identification of the active-site arginine in rat neutral endopeptidase 24.11 (enkephalinase) as arginine 102 and analysis of a glutamine 102 mutant. PubMed ID: 2703483

Sialorphin, a natural inhibitor of rat membrane-bound neutral endopeptidase that displays analgesic activity. PubMed ID: 12835417