Genular: Defining Cellular Identity and Function

Details for: Ngfr

Gene ID: 24596

Symbol: Ngfr

Ensembl ID: ENSRNOG00000005392

Description: nerve growth factor receptor

Associated with

Amyloid-beta binding
(GO:0001540)
Apoptotic process
(GO:0006915)
Axon guidance
(GO:0007411)
Calmodulin binding
(GO:0005516)
Cell-cell junction
(GO:0005911)
Cell surface
(GO:0009986)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to oxidative stress
(GO:0034599)
Central nervous system development
(GO:0007417)
Circadian regulation of gene expression
(GO:0032922)
Circadian rhythm
(GO:0007623)
Clathrin-coated endocytic vesicle
(GO:0045334)
Coreceptor activity
(GO:0015026)
Cytoplasm
(GO:0005737)
Death receptor activity
(GO:0005035)
Dendrite membrane
(GO:0032590)
Dendritic spine
(GO:0043197)
Detection of temperature stimulus
(GO:0016048)
Dorsal aorta development
(GO:0035907)
External side of plasma membrane
(GO:0009897)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Fibroblast proliferation
(GO:0048144)
Glucose homeostasis
(GO:0042593)
Growth cone
(GO:0030426)
Hair follicle development
(GO:0001942)
Hair follicle morphogenesis
(GO:0031069)
Identical protein binding
(GO:0042802)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular protein transport
(GO:0006886)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
(GO:1903588)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of dendritic spine development
(GO:0061000)
Negative regulation of fibroblast growth factor receptor signaling pathway
(GO:0040037)
Negative regulation of hair follicle development
(GO:0051799)
Negative regulation of mitochondrial depolarization
(GO:0051902)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of neuron projection development
(GO:0010977)
Nerve development
(GO:0021675)
Nerve growth factor binding
(GO:0048406)
Neuromuscular junction
(GO:0031594)
Neuronal cell body membrane
(GO:0032809)
Neuron apoptotic process
(GO:0051402)
Neurotrophin binding
(GO:0043121)
Neurotrophin trka receptor binding
(GO:0005168)
Nuclear envelope
(GO:0005635)
Nucleoplasm
(GO:0005654)
Odontogenesis of dentin-containing tooth
(GO:0042475)
Perikaryon
(GO:0043204)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of apoptotic signaling pathway
(GO:2001235)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of mirna transcription
(GO:1902895)
Positive regulation of myelination
(GO:0031643)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Positive regulation of neuron differentiation
(GO:0045666)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of odontogenesis of dentin-containing tooth
(GO:0042488)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of synaptic transmission, cholinergic
(GO:0032224)
Positive regulation of synaptic transmission, glutamatergic
(GO:0051968)
Postsynaptic density
(GO:0014069)
Preprotein binding
(GO:0070678)
Presynapse
(GO:0098793)
Presynaptic membrane
(GO:0042734)
Presynaptic modulation of chemical synaptic transmission
(GO:0099171)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Regulation of gene expression
(GO:0010468)
Regulation of reactive oxygen species metabolic process
(GO:2000377)
Response to lipopolysaccharide
(GO:0032496)
Rho protein signal transduction
(GO:0007266)
Signal transduction
(GO:0007165)
Skeletal muscle cell differentiation
(GO:0035914)
Skin development
(GO:0043588)
Small gtpase binding
(GO:0031267)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Tumor necrosis factor receptor superfamily member 16
A6HIA5_RAT

Genular Protein ID: 2189959389

Symbol: TNR16_RAT

Name: Tumor necrosis factor receptor superfamily member 16

UniProtKB Accession Codes:

P07174

Database IDs:

Citations:

PubMed ID: 3027580

Title: Gene transfer and molecular cloning of the rat nerve growth factor receptor.

PubMed ID: 3027580

DOI: 10.1038/325593a0

PubMed ID: 1446821

Title: Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter.

PubMed ID: 1446821

DOI: 10.1016/0378-1119(92)90128-c

PubMed ID: 9927421

Title: Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR.

PubMed ID: 9927421

DOI: 10.1093/emboj/18.3.616

PubMed ID: 10514511

Title: TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction.

PubMed ID: 10514511

DOI: 10.1074/jbc.274.42.30202

PubMed ID: 10985348

Title: NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis.

PubMed ID: 10985348

DOI: 10.1016/s0896-6273(00)00036-2

PubMed ID: 11150334

Title: An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors.

PubMed ID: 11150334

DOI: 10.1523/jneurosci.21-01-00176.2001

PubMed ID: 12095158

Title: PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor.

PubMed ID: 12095158

DOI: 10.1385/nmm:1:3:153

PubMed ID: 15378608

Title: Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein.

PubMed ID: 15378608

DOI: 10.1002/jnr.20262

PubMed ID: 16498402

Title: Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle.

PubMed ID: 16498402

DOI: 10.1038/sj.emboj.7601017

PubMed ID: 22155786

Title: Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac.

PubMed ID: 22155786

DOI: 10.1126/scisignal.2002060

PubMed ID: 24908487

Title: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia.

PubMed ID: 24908487

DOI: 10.1016/j.neuron.2014.04.022

PubMed ID: 27457814

Title: SorCS2 is required for BDNF-dependent plasticity in the hippocampus.

PubMed ID: 27457814

DOI: 10.1038/mp.2016.108

PubMed ID: 9305641

Title: NMR structure of the death domain of the p75 neurotrophin receptor.

PubMed ID: 9305641

DOI: 10.1093/emboj/16.16.4999

PubMed ID: 15131306

Title: Structure of nerve growth factor complexed with the shared neurotrophin receptor p75.

PubMed ID: 15131306

DOI: 10.1126/science.1095190

PubMed ID: 18596692

Title: Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex.

PubMed ID: 18596692

DOI: 10.1038/nature07089

PubMed ID: 20036257

Title: Molecular and structural insight into proNGF engagement of p75NTR and sortilin.

PubMed ID: 20036257

DOI: 10.1016/j.jmb.2009.12.030

PubMed ID: 27056327

Title: Structural Basis of p75 Transmembrane Domain Dimerization.

PubMed ID: 27056327

DOI: 10.1074/jbc.m116.723585

Sequence Information:

Length: 425
Mass: 45433
Checksum: B2E152D94D3827F8
Sequence:

MRRAGAACSA MDRLRLLLLL ILGVSSGGAK ETCSTGLYTH SGECCKACNL GEGVAQPCGA 
NQTVCEPCLD NVTFSDVVSA TEPCKPCTEC LGLQSMSAPC VEADDAVCRC AYGYYQDEET 
GHCEACSVCE VGSGLVFSCQ DKQNTVCEEC PEGTYSDEAN HVDPCLPCTV CEDTERQLRE 
CTPWADAECE EIPGRWIPRS TPPEGSDSTA PSTQEPEVPP EQDLVPSTVA DMVTTVMGSS 
QPVVTRGTTD NLIPVYCSIL AAVVVGLVAY IAFKRWNSCK QNKQGANSRP VNQTPPPEGE 
KLHSDSGISV DSQSLHDQQT HTQTASGQAL KGDGNLYSSL PLTKREEVEK LLNGDTWRHL 
AGELGYQPEH IDSFTHEACP VRALLASWGA QDSATLDALL AALRRIQRAD IVESLCSEST 
ATSPV

Genular Protein ID: 1419340146

Symbol: A6HIA5_RAT

Name: N/A

UniProtKB Accession Codes:

A6HIA5

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 425
Mass: 45438
Checksum: 3F81E62DE42FDC54
Sequence:

MRRAGAACSA MDRLRLLLLL ILGMSSGGAK ETCSTGLYTH SGECCKACNL GEGVAQPCGA 
NQTVCEPCLD SVTFSDVVSA TEPCKPCTEC LGLQSMSAPC VEADDAVCRC AYGYYQDEET 
GHCEACSVCE VGSGLVFSCQ DKQNTVCEEC PEGTYSDEAN HVDPCLPCTV CEDTERQLRE 
CTPWADAECE EIPGRWIPRS TPPEGSDSTA PSTQEPEVPP EQDLVPSTVA DMVTTVMGSS 
QPVVTRGTTD NLIPVYCSIL AAVVVGLVAY IAFKRWNSCK QNKQGANSRP VNQTPPPEGE 
KLHSDSGISV DSQSLHDQQT HTQTASGQAL KGDGNLYSSL PLTKREEVEK LLNGDTWRHL 
AGELGYQPEH IDSFTHEACP VRALLASWGA QDSATLDALL AALRRIQRAD IVESLCSEST 
ATSPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ngfr

Associated with

Other Information

Gene transfer and molecular cloning of the rat nerve growth factor receptor. PubMed ID: 3027580

Regulatory elements and transcriptional regulation by testosterone and retinoic acid of the rat nerve growth factor receptor promoter. PubMed ID: 1446821

Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. PubMed ID: 9927421

TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction. PubMed ID: 10514511

NRAGE, a novel MAGE protein, interacts with the p75 neurotrophin receptor and facilitates nerve growth factor dependent apoptosis. PubMed ID: 10985348

An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors. PubMed ID: 11150334

PLAIDD, a type II death domain protein that interacts with p75 neurotrophin receptor. PubMed ID: 12095158

Ternary complex with Trk, p75, and an ankyrin-rich membrane spanning protein. PubMed ID: 15378608

Bex1, a novel interactor of the p75 neurotrophin receptor, links neurotrophin signaling to the cell cycle. PubMed ID: 16498402

Neuronal growth cone retraction relies on proneurotrophin receptor signaling through Rac. PubMed ID: 22155786

SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. PubMed ID: 24908487

SorCS2 is required for BDNF-dependent plasticity in the hippocampus. PubMed ID: 27457814

NMR structure of the death domain of the p75 neurotrophin receptor. PubMed ID: 9305641

Structure of nerve growth factor complexed with the shared neurotrophin receptor p75. PubMed ID: 15131306

Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. PubMed ID: 18596692

Molecular and structural insight into proNGF engagement of p75NTR and sortilin. PubMed ID: 20036257

Structural Basis of p75 Transmembrane Domain Dimerization. PubMed ID: 27056327

Gene and alternative splicing annotation with AIR. PubMed ID: 15632090