Genular: Defining Cellular Identity and Function

Details for: Nos2

Gene ID: 24599

Symbol: Nos2

Ensembl ID: ENSRNOG00000057443

Description: nitric oxide synthase 2

Associated with

Hemostasis
(R-RNO-109582)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Nitric oxide stimulates guanylate cyclase
(R-RNO-392154)
Peroxisomal protein import
(R-RNO-9033241)
Platelet homeostasis
(R-RNO-418346)
Protein localization
(R-RNO-9609507)
Ros and rns production in phagocytes
(R-RNO-1222556)
Actin binding
(GO:0003779)
Arginine binding
(GO:0034618)
Arginine catabolic process
(GO:0006527)
Beta-catenin binding
(GO:0008013)
Blood vessel remodeling
(GO:0001974)
Cadherin binding
(GO:0045296)
Calmodulin binding
(GO:0005516)
Camp-dependent protein kinase regulator activity
(GO:0008603)
Cellular response to cytokine stimulus
(GO:0071345)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to lithium ion
(GO:0071285)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to redox state
(GO:0071461)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to type ii interferon
(GO:0071346)
Cellular response to vitamin d
(GO:0071305)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cgmp-mediated signaling
(GO:0019934)
Circadian rhythm
(GO:0007623)
Cortical cytoskeleton
(GO:0030863)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to bacterium
(GO:0042742)
Defense response to gram-negative bacterium
(GO:0050829)
Endothelial cell proliferation
(GO:0001935)
Extracellular space
(GO:0005615)
Flavin adenine dinucleotide binding
(GO:0050660)
Fmn binding
(GO:0010181)
Glycoside metabolic process
(GO:0016137)
G protein-coupled receptor signaling pathway coupled to cgmp nucleotide second messenger
(GO:0007199)
Heme binding
(GO:0020037)
Hsp90 protein binding
(GO:0051879)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Intracellular signal transduction
(GO:0035556)
Metal ion binding
(GO:0046872)
Nadp binding
(GO:0050661)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein catabolic process
(GO:0042177)
Nitric-oxide synthase activity
(GO:0004517)
Nitric-oxide synthase binding
(GO:0050998)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide mediated signal transduction
(GO:0007263)
Nucleus
(GO:0005634)
Ovulation from ovarian follicle
(GO:0001542)
Perinuclear region of cytoplasm
(GO:0048471)
Peroxisome
(GO:0005777)
Plasma membrane
(GO:0005886)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of guanylate cyclase activity
(GO:0031284)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of interleukin-8 production
(GO:0032757)
Positive regulation of killing of cells of another organism
(GO:0051712)
Prostaglandin secretion
(GO:0032310)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of blood pressure
(GO:0008217)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cytokine production involved in inflammatory response
(GO:1900015)
Regulation of insulin secretion
(GO:0050796)
Response to activity
(GO:0014823)
Response to bacterium
(GO:0009617)
Response to dexamethasone
(GO:0071548)
Response to estradiol
(GO:0032355)
Response to fructose
(GO:0009750)
Response to glucose
(GO:0009749)
Response to hormone
(GO:0009725)
Response to hypoxia
(GO:0001666)
Response to immobilization stress
(GO:0035902)
Response to lipopolysaccharide
(GO:0032496)
Response to mechanical stimulus
(GO:0009612)
Response to oxygen-glucose deprivation
(GO:0090649)
Response to tumor necrosis factor
(GO:0034612)
Retinoic acid receptor signaling pathway
(GO:0048384)
Superoxide metabolic process
(GO:0006801)
Tetrahydrobiopterin binding
(GO:0034617)

Other Information

Proteins

Nitric oxide synthase, inducible

Genular Protein ID: 2869938410

Symbol: NOS2_RAT

Name: Nitric oxide synthase, inducible

UniProtKB Accession Codes:

Q06518 O35765 O35766 O60591 O60604 P97774 Q63267 Q64005 Q64558

Database IDs:

Citations:

PubMed ID: 7680561

Title: Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells.

PubMed ID: 7680561

DOI: 10.1006/bbrc.1993.1188

PubMed ID: 7540573

Title: Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans.

PubMed ID: 7540573

DOI: 10.2337/diab.44.7.753

PubMed ID: 7513765

Title: Cloning and expression of inducible nitric oxide synthase from rat astrocytes.

PubMed ID: 7513765

DOI: 10.1002/jnr.490370313

PubMed ID: 7693462

Title: Molecular cloning of a cDNA encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells.

PubMed ID: 7693462

DOI: 10.1111/j.1432-1033.1993.tb18215.x

PubMed ID: 7682072

Title: Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene.

PubMed ID: 7682072

DOI: 10.1006/bbrc.1993.1283

PubMed ID: 7519448

Title: cDNA cloning and expression of inducible nitric oxide synthase from rat vascular smooth muscle cells.

PubMed ID: 7519448

DOI: 10.1016/0167-4781(94)90196-1

PubMed ID: 8913516

Title: Sequence analysis of inducible nitric oxide synthase in rat kidney, lung, and uterus.

PubMed ID: 8913516

DOI: 10.1248/bpb.19.1374

PubMed ID: 9851365

Title: Complete coding sequence of inducible nitric oxide synthase from human heart and skeletal muscle of patients with chronic heart failure.

PubMed ID: 9851365

DOI: 10.1006/niox.1998.0184

PubMed ID: 9535415

Title: Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats.

PubMed ID: 9535415

DOI: 10.1161/01.hyp.31.4.918

PubMed ID: 7516453

Title: Location of an inducible nitric oxide synthase mRNA in the normal kidney.

PubMed ID: 7516453

DOI: 10.1038/ki.1994.135

PubMed ID: 16641100

Title: Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.

PubMed ID: 16641100

DOI: 10.1073/pnas.0600895103

Sequence Information:

Length: 1147
Mass: 130628
Checksum: 77C77432DD8AB0A9
Sequence:

MACPWKFLFR VKSYQGDLKE EKDINNNVEK TPGAIPSPTT QDDPKSHKHQ NGFPQFLTGT 
AQNVPESLDK LHVTPSTRPQ HVRIKNWGNG EIFHDTLHHK ATSDISCKSK LCMGSIMNSK 
SLTRGPRDKP TPVEELLPQA IEFINQYYGS FKEAKIEEHL ARLEAVTKEI ETTGTYQLTL 
DELIFATKMA WRNAPRCIGR IQWSNLQVFD ARSCSTASEM FQHICRHILY ATNSGNIRSA 
ITVFPQRSDG KHDFRIWNSQ LIRYAGYQMP DGTIRGDPAT LEFTQLCIDL GWKPRYGRFD 
VLPLVLQAHG QDPEVFEIPP DLVLEVTMEH PKYEWFQELG LKWYALPAVA NMLLEVGGLE 
FPACPFNGWY MGTEIGVRDF CDTQRYNILE EVGRRMGLET HTLASLWKDR AVTEINAAVL 
HSFQKQNVTI MDHHTASESF MKHMQNEYRA RGGCPADWIW LVPPVSGSIT PVFHQEMLNY 
VLSPFYYYQI EPWKTHIWQD EKLRPRRREI RFTVLVKAVF FASVLMRKVM ASRVRATVLF 
ATETGKSEAL ARDLAALFSY AFNTKVVCME QYKANTLEEE QLLLVVTSTF GNGDCPSNGQ 
TLKKSLFMMK ELGHTFRYAV FGLGSSMYPQ FCAFAHDIDQ KLSHLGASQL APTGEGDELS 
GQEDAFRSWA VQTFRAACET FDVRSKHCIQ IPKRYTSNAT WEPEQYKLTQ SPESLDLNKA 
LSSIHAKNVF TMRLKSLQNL QSEKSSRTTL LVQLTFEGSR GPSYLPGEHL GIFPGNQTAL 
VQGILERVVD CSSPDQTVCL EVLDESGSYW VKDKRLPPCS LRQALTYFLD ITTPPTQLQL 
HKLARFATEE THRQRLEALC QPSEYNDWKF SNNPTFLEVL EEFPSLRVPA AFLLSQLPIL 
KPRYYSISSS QDHTPSEVHL TVAVVTYRTR DGQGPLHHGV CSTWINNLKP EDPVPCFVRS 
VSGFQLPEDP SQPCILIGPG TGIAPFRSFW QQRLHDSQHR GLKGGRMTLV FGCRHPEEDH 
LYQEEMQEMV RKGVLFQVHT GYSRLPGKPK VYVQDILQKE LADEVFSVLH GEQGHLYVCG 
DVRMARDVAT TLKKLVAAKL NLSEEQVEDY FFQLKSQKRY HEDIFGAVFS YGAKKGNTLE 
EPKGTRL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nos2

Associated with

Other Information

Cloning of inducible nitric oxide synthase in rat vascular smooth muscle cells. PubMed ID: 7680561

Cloning and expression of cytokine-inducible nitric oxide synthase cDNA from rat islets of Langerhans. PubMed ID: 7540573

Cloning and expression of inducible nitric oxide synthase from rat astrocytes. PubMed ID: 7513765

Molecular cloning of a cDNA encoding an inducible calmodulin-dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells. PubMed ID: 7693462

Hepatocytes and macrophages express an identical cytokine inducible nitric oxide synthase gene. PubMed ID: 7682072

cDNA cloning and expression of inducible nitric oxide synthase from rat vascular smooth muscle cells. PubMed ID: 7519448

Sequence analysis of inducible nitric oxide synthase in rat kidney, lung, and uterus. PubMed ID: 8913516

Complete coding sequence of inducible nitric oxide synthase from human heart and skeletal muscle of patients with chronic heart failure. PubMed ID: 9851365

Vascular smooth muscle nitric oxide synthase anomalies in Dahl/Rapp salt-sensitive rats. PubMed ID: 9535415

Location of an inducible nitric oxide synthase mRNA in the normal kidney. PubMed ID: 7516453

Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites. PubMed ID: 16641100