ALOX15 | ENSG00000161905 | NCBI 246

Details for: ALOX15

Gene ID: 246

Symbol: ALOX15

Ensembl ID: ENSG00000161905

Description: arachidonate 15-lipoxygenase

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Biosynthesis of dha-derived spms
(R-HSA-9018677)
Biosynthesis of dpa-derived spms
(R-HSA-9018683)
Biosynthesis of dpan-3 spms
(R-HSA-9025094)
Biosynthesis of dpan-3-derived protectins and resolvins
(R-HSA-9026286)
Biosynthesis of dpan-6 spms
(R-HSA-9025106)
Biosynthesis of e-series 18(r)-resolvins
(R-HSA-9023661)
Biosynthesis of e-series 18(s)-resolvins
(R-HSA-9018896)
Biosynthesis of epa-derived spms
(R-HSA-9018679)
Biosynthesis of protectins
(R-HSA-9018681)
Biosynthesis of specialized proresolving mediators (spms)
(R-HSA-9018678)
Cytokine signaling in immune system
(R-HSA-1280215)
Fatty acid metabolism
(R-HSA-8978868)
Immune system
(R-HSA-168256)
Interleukin-4 and interleukin-13 signaling
(R-HSA-6785807)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Signaling by interleukins
(R-HSA-449147)
Synthesis of 12-eicosatetraenoic acid derivatives
(R-HSA-2142712)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-HSA-2142770)
Synthesis of leukotrienes (lt) and eoxins (ex)
(R-HSA-2142691)
Apoptotic cell clearance
(GO:0043277)
Arachidonate 12(s)-lipoxygenase activity
(GO:0004052)
Arachidonate 15-lipoxygenase activity
(GO:0050473)
Arachidonic acid metabolic process
(GO:0019369)
Bone mineralization
(GO:0030282)
Cellular response to calcium ion
(GO:0071277)
Cellular response to interleukin-13
(GO:0035963)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Fatty acid oxidation
(GO:0019395)
Hepoxilin biosynthetic process
(GO:0051122)
Inflammatory response
(GO:0006954)
Iron ion binding
(GO:0005506)
Linoleate 13s-lipoxygenase activity
(GO:0016165)
Linoleic acid metabolic process
(GO:0043651)
Lipid droplet
(GO:0005811)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxin a4 biosynthetic process
(GO:2001303)
Lipoxygenase pathway
(GO:0019372)
Long-chain fatty acid biosynthetic process
(GO:0042759)
Membrane
(GO:0016020)
Negative regulation of adaptive immune response
(GO:0002820)
Ossification
(GO:0001503)
Phosphatidylethanolamine biosynthetic process
(GO:0006646)
Phosphatidylinositol-4,5-bisphosphate binding
(GO:0005546)
Plasma membrane
(GO:0005886)
Positive regulation of actin filament polymerization
(GO:0030838)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Protein binding
(GO:0005515)
Regulation of engulfment of apoptotic cell
(GO:1901074)
Regulation of inflammatory response
(GO:0050727)
Regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035358)
Response to endoplasmic reticulum stress
(GO:0034976)
Wound healing
(GO:0042060)

Other Information

Proteins

Arachidonate 15-lipoxygenase

Genular Protein ID: 1151080486

Symbol: LOX15_HUMAN

Name: Arachidonate 15-lipoxygenase

UniProtKB Accession Codes:

P16050 A8K2P4 B7ZA11 Q8N6R7 Q99657

Database IDs:

Citations:

PubMed ID: 3202857

Title: Molecular cloning and primary structure of human 15-lipoxygenase.

PubMed ID: 3202857

DOI: 10.1016/s0006-291x(88)80271-7

PubMed ID: 9224951

Title: Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene.

PubMed ID: 9224951

DOI: 10.1016/s0167-4781(97)00005-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9700053

Title: Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes.

PubMed ID: 9700053

DOI: 10.1023/a:1006813009006

PubMed ID: 3356688

Title: Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.

PubMed ID: 3356688

DOI: 10.1016/s0021-9258(18)60719-7

PubMed ID: 1662607

Title: Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes.

PubMed ID: 1662607

DOI: 10.1111/j.1432-1033.1991.tb16495.x

PubMed ID: 1944593

Title: A primary determinant for lipoxygenase positional specificity.

PubMed ID: 1944593

DOI: 10.1038/354149a0

PubMed ID: 8334154

Title: Overexpression, purification and characterization of human recombinant 15-lipoxygenase.

PubMed ID: 8334154

DOI: 10.1016/0005-2760(93)90085-n

PubMed ID: 9414270

Title: Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme.

PubMed ID: 9414270

PubMed ID: 11418015

Title: Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells.

PubMed ID: 11418015

DOI: 10.1054/plef.2001.0263

PubMed ID: 17052953

Title: Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity.

PubMed ID: 17052953

DOI: 10.1016/j.bbalip.2006.09.007

PubMed ID: 18755188

Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.

PubMed ID: 18755188

DOI: 10.1016/j.febslet.2008.08.017

PubMed ID: 19528634

Title: 15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism.

PubMed ID: 19528634

DOI: 10.1194/jlr.m900081-jlr200

PubMed ID: 21831839

Title: 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.

PubMed ID: 21831839

DOI: 10.1073/pnas.1018075108

PubMed ID: 23242647

Title: Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration.

PubMed ID: 23242647

DOI: 10.1194/jlr.m033746

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 25293588

Title: Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.

PubMed ID: 25293588

DOI: 10.1194/jlr.m054072

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 17959182

Title: A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.

PubMed ID: 17959182

DOI: 10.1016/j.atherosclerosis.2007.09.003

Sequence Information:

Length: 662
Mass: 74804
Checksum: 9ACF7FE7863A045C
Sequence:

MGLYRIRVST GASLYAGSNN QVQLWLVGQH GEAALGKRLW PARGKETELK VEVPEYLGPL 
LFVKLRKRHL LKDDAWFCNW ISVQGPGAGD EVRFPCYRWV EGNGVLSLPE GTGRTVGEDP 
QGLFQKHREE ELEERRKLYR WGNWKDGLIL NMAGAKLYDL PVDERFLEDK RVDFEVSLAK 
GLADLAIKDS LNVLTCWKDL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGANPVV 
LRRSAHLPAR LVFPPGMEEL QAQLEKELEG GTLFEADFSL LDGIKANVIL CSQQHLAAPL 
VMLKLQPDGK LLPMVIQLQL PRTGSPPPPL FLPTDPPMAW LLAKCWVRSS DFQLHELQSH 
LLRGHLMAEV IVVATMRCLP SIHPIFKLII PHLRYTLEIN VRARTGLVSD MGIFDQIMST 
GGGGHVQLLK QAGAFLTYSS FCPPDDLADR GLLGVKSSFY AQDALRLWEI IYRYVEGIVS 
LHYKTDVAVK DDPELQTWCR EITEIGLQGA QDRGFPVSLQ ARDQVCHFVT MCIFTCTGQH 
ASVHLGQLDW YSWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRRQ 
PVMVAVGQHE EEYFSGPEPK AVLKKFREEL AALDKEIEIR NAKLDMPYEY LRPSVVENSV 
AI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ALOX15

Associated with

Other Information

Molecular cloning and primary structure of human 15-lipoxygenase. PubMed ID: 3202857

Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene. PubMed ID: 9224951

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes. PubMed ID: 9700053

Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases. PubMed ID: 3356688

Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes. PubMed ID: 1662607

A primary determinant for lipoxygenase positional specificity. PubMed ID: 1944593

Overexpression, purification and characterization of human recombinant 15-lipoxygenase. PubMed ID: 8334154

Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme. PubMed ID: 9414270

Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells. PubMed ID: 11418015

Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity. PubMed ID: 17052953

Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes. PubMed ID: 18755188

15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism. PubMed ID: 19528634

15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells. PubMed ID: 21831839

Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration. PubMed ID: 23242647

Functional characterization of genetic enzyme variations in human lipoxygenases. PubMed ID: 24282679

Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction. PubMed ID: 25293588

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. PubMed ID: 32404334

A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease. PubMed ID: 17959182