Details for: ALOX15

Gene ID: 246

Symbol: ALOX15

Ensembl ID: ENSG00000161905

Description: arachidonate 15-lipoxygenase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 4.84
    Marker Score: 4638
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3171
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.03
    Marker Score: 22537
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.58
    Marker Score: 22408
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.43
    Marker Score: 8342
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1994
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.88
    Marker Score: 1256
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.81
    Marker Score: 3442
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.38
    Marker Score: 942
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 1.38
    Marker Score: 687
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 854
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4815
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251809
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.93
    Marker Score: 434
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.87
    Marker Score: 1580
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.85
    Marker Score: 405
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.82
    Marker Score: 5460
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.74
    Marker Score: 859
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.72
    Marker Score: 1473
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.71
    Marker Score: 911
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.62
    Marker Score: 413
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.62
    Marker Score: 9632
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.61
    Marker Score: 1151
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.6
    Marker Score: 193
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 466
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.57
    Marker Score: 282
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.56
    Marker Score: 225
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.48
    Marker Score: 126
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.45
    Marker Score: 129
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.43
    Marker Score: 195
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.42
    Marker Score: 260
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 397
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.39
    Marker Score: 113
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 239
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.34
    Marker Score: 166
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.33
    Marker Score: 195
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.33
    Marker Score: 686.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 311
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.29
    Marker Score: 175
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.27
    Marker Score: 165
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.25
    Marker Score: 269
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.24
    Marker Score: 78
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.23
    Marker Score: 96
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.23
    Marker Score: 213
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.23
    Marker Score: 108
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.19
    Marker Score: 133
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.17
    Marker Score: 155
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.16
    Marker Score: 160
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.16
    Marker Score: 109
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.15
    Marker Score: 419
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 0.14
    Marker Score: 153
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.14
    Marker Score: 146
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 78
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.13
    Marker Score: 157.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.12
    Marker Score: 135
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.12
    Marker Score: 24
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.12
    Marker Score: 76
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.11
    Marker Score: 289
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.11
    Marker Score: 49
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.11
    Marker Score: 169
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.11
    Marker Score: 96
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.1
    Marker Score: 70
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.1
    Marker Score: 63.5
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.1
    Marker Score: 64
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: brush cell of trachebronchial tree (CL0002075)
    Fold Change: 0.1
    Marker Score: 30
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.1
    Marker Score: 24
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1
    Marker Score: 821
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.09
    Marker Score: 28
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.09
    Marker Score: 112.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.09
    Marker Score: 24

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Other Information

**Key characteristics:** - LOX15 is a transmembrane protein with a predicted molecular weight of approximately 150 kDa. - It belongs to the LOX family of eicosanoid biosynthetase enzymes, which are involved in the production of eicosanoids from arachidonic acid (AA). - LOX15 has been shown to be a key regulator of inflammation and immune responses. **Pathways and functions:** - LOX15 is involved in multiple pathways involved in inflammation and immune responses, including: - Arachidonic acid metabolism - Biosynthesis of DHA-derived spms - Biosynthesis of DPA-derived spms - Biosynthesis of dpan-3 spms - Biosynthesis of dpan-6 spms - Biosynthesis of e-series 18(r)-resolvins - Biosynthesis of e-series 18(s)-resolvins - Biosynthesis of epa-derived spms - Biosynthesis of protectins - Regulation of cytokine signaling - Fatty acid metabolism - Immune system - Interleukin-4 and interleukin-13 signaling - Metabolism of lipids - Signaling by interleukins - Synthesis of 12-eicosatetraenoic acid derivatives - Synthesis of 15-eicosatetraenoic acid derivatives - Synthesis of leukotrienes (lt) and eoxins (ex) **Clinical significance:** - LOX15 gene variants have been linked to various diseases, including asthma, inflammatory bowel disease, and cardiovascular disease. - LOX15 inhibitors are being investigated as potential therapeutic agents for these diseases. - Understanding the role of LOX15 in inflammation and immune responses could provide new insights for disease treatment.

Genular Protein ID: 1151080486

Symbol: LOX15_HUMAN

Name: Arachidonate 15-lipoxygenase

UniProtKB Accession Codes:

P16050 A8K2P4 B7ZA11 Q8N6R7 Q99657

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 2 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 86 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 5 DrugCentral 1 EC 3 EMBL 8 Ensembl 3 GO 35 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 10 RefSeq 1 Rhea 54 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3202857

Title: Molecular cloning and primary structure of human 15-lipoxygenase.

PubMed ID: 3202857

DOI: 10.1016/s0006-291x(88)80271-7

PubMed ID: 9224951

Title: Characterization and sequence of an additional 15-lipoxygenase transcript and of the human gene.

PubMed ID: 9224951

DOI: 10.1016/s0167-4781(97)00005-5

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9700053

Title: Human 15-lipoxygenase gene promoter: analysis and identification of DNA binding sites for IL-13-induced regulatory factors in monocytes.

PubMed ID: 9700053

DOI: 10.1023/a:1006813009006

PubMed ID: 3356688

Title: Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.

PubMed ID: 3356688

DOI: 10.1016/s0021-9258(18)60719-7

PubMed ID: 1662607

Title: Purification of two forms of arachidonate 15-lipoxygenase from human leukocytes.

PubMed ID: 1662607

DOI: 10.1111/j.1432-1033.1991.tb16495.x

PubMed ID: 1944593

Title: A primary determinant for lipoxygenase positional specificity.

PubMed ID: 1944593

DOI: 10.1038/354149a0

PubMed ID: 8334154

Title: Overexpression, purification and characterization of human recombinant 15-lipoxygenase.

PubMed ID: 8334154

DOI: 10.1016/0005-2760(93)90085-n

PubMed ID: 9414270

Title: Membrane translocation of 15-lipoxygenase in hematopoietic cells is calcium-dependent and activates the oxygenase activity of the enzyme.

PubMed ID: 9414270

PubMed ID: 11418015

Title: Evaluation of the activity and localization of 15-lipoxygenase-1 after introduction into human colorectal carcinoma Caco-2 cells.

PubMed ID: 11418015

DOI: 10.1054/plef.2001.0263

PubMed ID: 17052953

Title: Interaction of human 15-lipoxygenase-1 with phosphatidylinositol bisphosphates results in increased enzyme activity.

PubMed ID: 17052953

DOI: 10.1016/j.bbalip.2006.09.007

PubMed ID: 18755188

Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.

PubMed ID: 18755188

DOI: 10.1016/j.febslet.2008.08.017

PubMed ID: 19528634

Title: 15(S)-Lipoxygenase-1 associates with neutral lipid droplets in macrophage foam cells: evidence of lipid droplet metabolism.

PubMed ID: 19528634

DOI: 10.1194/jlr.m900081-jlr200

PubMed ID: 21831839

Title: 15-Lipoxygenase 1 interacts with phosphatidylethanolamine-binding protein to regulate MAPK signaling in human airway epithelial cells.

PubMed ID: 21831839

DOI: 10.1073/pnas.1018075108

PubMed ID: 23242647

Title: Biosynthesis, isolation, and NMR analysis of leukotriene A epoxides: substrate chirality as a determinant of the cis or trans epoxide configuration.

PubMed ID: 23242647

DOI: 10.1194/jlr.m033746

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 25293588

Title: Lipoxygenase-catalyzed transformation of epoxy fatty acids to hydroxy-endoperoxides: a potential P450 and lipoxygenase interaction.

PubMed ID: 25293588

DOI: 10.1194/jlr.m054072

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 17959182

Title: A near null variant of 12/15-LOX encoded by a novel SNP in ALOX15 and the risk of coronary artery disease.

PubMed ID: 17959182

DOI: 10.1016/j.atherosclerosis.2007.09.003

Sequence Information:

  • Length: 662
  • Mass: 74804
  • Checksum: 9ACF7FE7863A045C
  • Sequence:
    • MGLYRIRVST GASLYAGSNN QVQLWLVGQH GEAALGKRLW PARGKETELK VEVPEYLGPL 
LFVKLRKRHL LKDDAWFCNW ISVQGPGAGD EVRFPCYRWV EGNGVLSLPE GTGRTVGEDP 
QGLFQKHREE ELEERRKLYR WGNWKDGLIL NMAGAKLYDL PVDERFLEDK RVDFEVSLAK 
GLADLAIKDS LNVLTCWKDL DDFNRIFWCG QSKLAERVRD SWKEDALFGY QFLNGANPVV 
LRRSAHLPAR LVFPPGMEEL QAQLEKELEG GTLFEADFSL LDGIKANVIL CSQQHLAAPL 
VMLKLQPDGK LLPMVIQLQL PRTGSPPPPL FLPTDPPMAW LLAKCWVRSS DFQLHELQSH 
LLRGHLMAEV IVVATMRCLP SIHPIFKLII PHLRYTLEIN VRARTGLVSD MGIFDQIMST 
GGGGHVQLLK QAGAFLTYSS FCPPDDLADR GLLGVKSSFY AQDALRLWEI IYRYVEGIVS 
LHYKTDVAVK DDPELQTWCR EITEIGLQGA QDRGFPVSLQ ARDQVCHFVT MCIFTCTGQH 
ASVHLGQLDW YSWVPNAPCT MRLPPPTTKD ATLETVMATL PNFHQASLQM SITWQLGRRQ 
PVMVAVGQHE EEYFSGPEPK AVLKKFREEL AALDKEIEIR NAKLDMPYEY LRPSVVENSV 
AI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.