Genular: Defining Cellular Identity and Function

Details for: Nos3

Gene ID: 24600

Symbol: Nos3

Ensembl ID: ENSRNOG00000009348

Description: nitric oxide synthase 3

Associated with

Enos activation
(R-RNO-203615)
Esr-mediated signaling
(R-RNO-8939211)
Extra-nuclear estrogen signaling
(R-RNO-9009391)
Hemostasis
(R-RNO-109582)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Metabolism
(R-RNO-1430728)
Metabolism of cofactors
(R-RNO-8978934)
Metabolism of nitric oxide: nos3 activation and regulation
(R-RNO-202131)
Metabolism of vitamins and cofactors
(R-RNO-196854)
Nitric oxide stimulates guanylate cyclase
(R-RNO-392154)
Nosip mediated enos trafficking
(R-RNO-203754)
Nostrin mediated enos trafficking
(R-RNO-203641)
Platelet homeostasis
(R-RNO-418346)
Ros and rns production in phagocytes
(R-RNO-1222556)
Signaling by nuclear receptors
(R-RNO-9006931)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signaling by vegf
(R-RNO-194138)
Signal transduction
(R-RNO-162582)
Tetrahydrobiopterin (bh4) synthesis, recycling, salvage and regulation
(R-RNO-1474151)
Vegfa-vegfr2 pathway
(R-RNO-4420097)
Vegfr2 mediated vascular permeability
(R-RNO-5218920)
Actin binding
(GO:0003779)
Actin monomer binding
(GO:0003785)
Angiogenesis
(GO:0001525)
Aortic valve morphogenesis
(GO:0003180)
Arginine binding
(GO:0034618)
Arginine catabolic process
(GO:0006527)
Beta-catenin binding
(GO:0008013)
Blood vessel remodeling
(GO:0001974)
Cadherin binding
(GO:0045296)
Calcium ion transport
(GO:0006816)
Calmodulin binding
(GO:0005516)
Cellular response to heat
(GO:0034605)
Cellular response to insulin stimulus
(GO:0032869)
Endocardial cushion morphogenesis
(GO:0003203)
Endothelial cell migration
(GO:0043542)
Female pregnancy
(GO:0007565)
Flavin adenine dinucleotide binding
(GO:0050660)
Fmn binding
(GO:0010181)
Heme binding
(GO:0020037)
Hsp90 protein binding
(GO:0051879)
In utero embryonic development
(GO:0001701)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Lung development
(GO:0030324)
Metal ion binding
(GO:0046872)
Nadp binding
(GO:0050661)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of muscle hyperplasia
(GO:0014740)
Negative regulation of potassium ion transport
(GO:0043267)
Nitric-oxide synthase activity
(GO:0004517)
Nitric-oxide synthase binding
(GO:0050998)
Nitric oxide biosynthetic process
(GO:0006809)
Nitric oxide mediated signal transduction
(GO:0007263)
Ovulation from ovarian follicle
(GO:0001542)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of guanylate cyclase activity
(GO:0031284)
Potassium ion transport
(GO:0006813)
Protein binding
(GO:0005515)
Pulmonary valve morphogenesis
(GO:0003184)
Regulation of nervous system process
(GO:0031644)
Regulation of sodium ion transport
(GO:0002028)
Regulation of systemic arterial blood pressure by endothelin
(GO:0003100)
Regulation of the force of heart contraction by chemical signal
(GO:0003057)
Removal of superoxide radicals
(GO:0019430)
Response to activity
(GO:0014823)
Response to amino acid
(GO:0043200)
Response to carbohydrate
(GO:0009743)
Response to cytokine
(GO:0034097)
Response to erythropoietin
(GO:0036017)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to fluid shear stress
(GO:0034405)
Response to fructose
(GO:0009750)
Response to hormone
(GO:0009725)
Response to hypoxia
(GO:0001666)
Response to lead ion
(GO:0010288)
Response to lipopolysaccharide
(GO:0032496)
Response to mechanical stimulus
(GO:0009612)
Response to metal ion
(GO:0010038)
Response to nicotine
(GO:0035094)
Response to nutrient levels
(GO:0031667)
Response to organic cyclic compound
(GO:0014070)
Response to peptide hormone
(GO:0043434)
Response to xenobiotic stimulus
(GO:0009410)
Scaffold protein binding
(GO:0097110)
Smooth muscle hyperplasia
(GO:0014806)
Tetrahydrobiopterin binding
(GO:0034617)
Vasodilation
(GO:0042311)

Other Information

Proteins

Constitutive NOS

Genular Protein ID: 2427262092

Symbol: NOS3_RAT

Name: Constitutive NOS

UniProtKB Accession Codes:

Q62600 O88672 O89041 Q62734 Q68GV6 Q75NE4

Database IDs:

Citations:

PubMed ID: 15105416

Title: NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity.

PubMed ID: 15105416

DOI: 10.1074/jbc.m401471200

PubMed ID: 15808839

Title: Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90.

PubMed ID: 15808839

DOI: 10.1016/j.yjmcc.2005.02.005

PubMed ID: 7527874

Title: Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney.

PubMed ID: 7527874

DOI: 10.1038/ki.1994.318

PubMed ID: 7537461

Title: Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development.

PubMed ID: 7537461

DOI: 10.1152/ajplung.1995.268.4.l589

PubMed ID: 10025949

Title: AMP-activated protein kinase phosphorylation of endothelial NO synthase.

PubMed ID: 10025949

DOI: 10.1016/s0014-5793(98)01705-0

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1202
Mass: 133290
Checksum: 52E905C3134E244D
Sequence:

MGNLKSVGQE PGPPCGLGLG LGLGLCGKQG PASPAPEPSQ APVPPSPTRP APDHSPPLTR 
PPDGPKFPRV KNWEVGSITY DTLSAQAQQD GPCTPRRCLG SLVFPRKLQS RPTQGPSPTE 
QLLGQARDFI NQYYNSIKRS GSQAHEQRLQ EVEAEVVATG TYQLRESELV FGAKQAWRNA 
PRCVGRIQWG KLQVFDARDC RTAQEMFTYI CNHIKYATNR GNLRSAITVF PQRYAGRGDF 
RIWNSQLVRY AGYRQQDGSV RGDPANVEIT ELCIQHGWTP GNGRFDVLPL LLQAPDEPPE 
LFTLPPELVL EVPLEHPTLE WFAALGLRWY ALPAVSNMLL EIGGLEFPAA PFSGWYMSSE 
IGMRDLCDPH RYNILEDVAV CMDLDTRTTS SLWKDKAAVE INVAVLYSYQ LAKVTIVDHH 
AATASFMKHL ENEQKARGGC PADWAWIVPP ISGSLTPVFH QEMVNYFLSP AFRYQPDPWK 
GSAAKGTGIT RKKTFKEVAN AVKISASLMG TVMAKRVKAT ILYGSETGRA QSYAQQLGRL 
FRKAFDPRVL CMDEYDVVSL EHEALVLVVT STFGNGDPPE NGESFAAALM EMSGPYNSSP 
RPEQHKSYKI RFNSVSCSDP LVSSWRRKRK ESSNTDSAGA LGTLRFCVFG LGSRAYPHFC 
AFARAVDTRL EELGGERLLQ LGQGDELCGQ EEAFRGWAQA AFQAACETFC VGEDAKAAAR 
DIFSPKRSWK RQRYRLSTQA ESLQLLPRLT HVHRRKMFQA TILSVENLQS SKSTRATILV 
RLDTGSQEGL QYQPGDHIGV CPPNRPGLVE ALLSRVEDPP PSTEPVAVEQ LEKGSPGGPP 
PGWVRDPRLP PCTLRQALTY FLDITSPPSP RLLRLLSTLA EESSEQQELE ALSQDPRRYE 
EWKWFRCPTL LEVLEQFPSV ALPAPLILTQ LPLLQPRYYS VSSAPSAHPG EIHLTVAVLA 
YRTQDGLGPL HYGVCSTWMS QLKAGDPVPC FIRGAPSFRL PPDPNLPCIL VGPGTGIAPF 
RGFWQDRLHD IEIKGLQPAP MTLVFGCRCS QLDHLYRDEV LDAQQRGVFG QVLTAFSRDP 
GSPKTYVQDL LRTELAAEVH RVLCLEQGHM FVCGDVTMAT SVLQTVQRIL ATEGSMELDE 
AGDVIGVLRD QQRYHEDIFG LTLRTQEVTS RIRTQSFSLQ ERQLRGAVPW SFDPPTQETP 
GS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nos3

Associated with

Other Information

NIDD, a novel DHHC-containing protein, targets neuronal nitric-oxide synthase (nNOS) to the synaptic membrane through a PDZ-dependent interaction and regulates nNOS activity. PubMed ID: 15105416

Increased resistance to myocardial ischemia in the Brown Norway vs. Dahl S rat: role of nitric oxide synthase and Hsp90. PubMed ID: 15808839

Differential expression and induction of mRNAs encoding two inducible nitric oxide synthases in rat kidney. PubMed ID: 7527874

Constitutive endothelial nitric oxide synthase gene expression is regulated during lung development. PubMed ID: 7537461

AMP-activated protein kinase phosphorylation of endothelial NO synthase. PubMed ID: 10025949