Genular: Defining Cellular Identity and Function

Details for: Nppa

Gene ID: 24602

Symbol: Nppa

Ensembl ID: ENSRNOG00000008176

Description: natriuretic peptide A

Associated with

Cardiac conduction
(R-RNO-5576891)
Muscle contraction
(R-RNO-397014)
Physiological factors
(R-RNO-5578768)
Blood vessel diameter maintenance
(GO:0097746)
Brush border
(GO:0005903)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cell growth involved in cardiac muscle cell development
(GO:0061049)
Cell projection
(GO:0042995)
Cellular response to angiotensin
(GO:1904385)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to mechanical stimulus
(GO:0071260)
Cgmp-mediated signaling
(GO:0019934)
Cgmp biosynthetic process
(GO:0006182)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Female pregnancy
(GO:0007565)
Glycinergic synapse
(GO:0098690)
Heart development
(GO:0007507)
Hormone activity
(GO:0005179)
Hormone receptor binding
(GO:0051427)
Mast cell granule
(GO:0042629)
Multicellular organismal-level water homeostasis
(GO:0050891)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of collecting lymphatic vessel constriction
(GO:1903815)
Negative regulation of epidermal growth factor receptor signaling pathway
(GO:0042059)
Negative regulation of systemic arterial blood pressure
(GO:0003085)
Neuropeptide hormone activity
(GO:0005184)
Neuropeptide receptor binding
(GO:0071855)
Neuropeptide signaling pathway
(GO:0007218)
Perikaryon
(GO:0043204)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of cardiac muscle contraction
(GO:0060452)
Positive regulation of cgmp-mediated signaling
(GO:0010753)
Positive regulation of heart rate
(GO:0010460)
Positive regulation of histamine secretion by mast cell
(GO:1903595)
Positive regulation of potassium ion export across plasma membrane
(GO:1903766)
Protein-containing complex
(GO:0032991)
Protein folding
(GO:0006457)
Receptor guanylyl cyclase signaling pathway
(GO:0007168)
Regulation of atrial cardiac muscle cell membrane repolarization
(GO:0060372)
Regulation of blood pressure
(GO:0008217)
Regulation of body fluid levels
(GO:0050878)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
(GO:1902514)
Response to 3-methylcholanthrene
(GO:1904681)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Signaling receptor binding
(GO:0005102)
Sodium ion export across plasma membrane
(GO:0036376)
Synaptic signaling via neuropeptide
(GO:0099538)
Vasodilation
(GO:0042311)

Other Information

Proteins

ANF_RAT

Genular Protein ID: 3535689192

Symbol: ANF_RAT

Name: N/A

UniProtKB Accession Codes:

P01161

Database IDs:

Citations:

PubMed ID: 6547210

Title: Cloning and sequence analysis of the cDNA for the rat atrial natriuretic factor precursor.

PubMed ID: 6547210

DOI: 10.1038/309719a0

PubMed ID: 6328328

Title: Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence.

PubMed ID: 6328328

DOI: 10.1038/309722a0

PubMed ID: 6234658

Title: The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone.

PubMed ID: 6234658

DOI: 10.1126/science.6234658

PubMed ID: 6239103

Title: Identification of rat gamma atrial natriuretic polypeptide and characterization of the cDNA encoding its precursor.

PubMed ID: 6239103

DOI: 10.1038/312152a0

PubMed ID: 2985557

Title: The gene for rat atrial natriuretic factor.

PubMed ID: 2985557

DOI: 10.1016/s0021-9258(18)89107-4

PubMed ID: 6238331

Title: Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors.

PubMed ID: 6238331

DOI: 10.1073/pnas.81.20.6325

PubMed ID: 2962707

Title: The elucidation of the structure of atrial natriuretic factor, a new peptide hormone.

PubMed ID: 2962707

DOI: 10.1139/y87-315

PubMed ID: 1837590

Title: Differential expression of natriuretic peptide genes in cardiac and extracardiac tissues.

PubMed ID: 1837590

DOI: 10.1210/mend-5-9-1292

PubMed ID: 2951736

Title: Identification of atrial natriuretic factor gene transcripts in the central nervous system of the rat.

PubMed ID: 2951736

DOI: 10.1073/pnas.84.8.2175

PubMed ID: 6233494

Title: Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide.

PubMed ID: 6233494

DOI: 10.1038/309717a0

PubMed ID: 6419347

Title: Purification and sequence analysis of bioactive atrial peptides (atriopeptins).

PubMed ID: 6419347

DOI: 10.1126/science.6419347

PubMed ID: 6232612

Title: Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms.

PubMed ID: 6232612

DOI: 10.1073/pnas.81.9.2640

PubMed ID: 3160114

Title: Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide.

PubMed ID: 3160114

DOI: 10.1126/science.3160114

PubMed ID: 2966345

Title: NH2-terminal fragment of rat pro-atrial natriuretic factor in the circulation: identification, radioimmunoassay and half-life.

PubMed ID: 2966345

DOI: 10.1016/0196-9781(88)90008-3

PubMed ID: 2525379

Title: Occurrence of a novel cardiac natriuretic peptide in rats.

PubMed ID: 2525379

DOI: 10.1016/0006-291x(89)92661-2

PubMed ID: 2966343

Title: Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney.

PubMed ID: 2966343

DOI: 10.1016/0196-9781(88)90024-1

PubMed ID: 7831500

Title: Lack of biologic activity or specific binding of amino-terminal pro-ANP segments in the rat.

PubMed ID: 7831500

DOI: 10.1016/0167-0115(94)90612-2

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 15117952

Title: Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction.

PubMed ID: 15117952

DOI: 10.1074/jbc.m313222200

Sequence Information:

Length: 152
Mass: 16556
Checksum: D8AAB2191E29519F
Sequence:

MGSFSITKGF FLFLAFWLPG HIGANPVYSA VSNTDLMDFK NLLDHLEEKM PVEDEVMPPQ 
ALSEQTDEAG AALSSLSEVP PWTGEVNPSQ RDGGALGRGP WDPSDRSALL KSKLRALLAG 
PRSLRRSSCF GGRIDRIGAQ SGLGCNSFRY RR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nppa

Associated with

Other Information

Cloning and sequence analysis of the cDNA for the rat atrial natriuretic factor precursor. PubMed ID: 6547210

Structure of rat atrial natriuretic factor precursor deduced from cDNA sequence. PubMed ID: 6328328

The structure of rat preproatrial natriuretic factor as defined by a complementary DNA clone. PubMed ID: 6234658

Identification of rat gamma atrial natriuretic polypeptide and characterization of the cDNA encoding its precursor. PubMed ID: 6239103

The gene for rat atrial natriuretic factor. PubMed ID: 2985557

Molecular cloning and characterization of DNA sequences encoding rat and human atrial natriuretic factors. PubMed ID: 6238331

The elucidation of the structure of atrial natriuretic factor, a new peptide hormone. PubMed ID: 2962707

Differential expression of natriuretic peptide genes in cardiac and extracardiac tissues. PubMed ID: 1837590

Identification of atrial natriuretic factor gene transcripts in the central nervous system of the rat. PubMed ID: 2951736

Purification, sequencing and synthesis of natriuretic and vasoactive rat atrial peptide. PubMed ID: 6233494

Purification and sequence analysis of bioactive atrial peptides (atriopeptins). PubMed ID: 6419347

Amino acid sequence of homologous rat atrial peptides: natriuretic activity of native and synthetic forms. PubMed ID: 6232612

Ser-Leu-Arg-Arg-atriopeptin III: the major circulating form of atrial peptide. PubMed ID: 3160114

NH2-terminal fragment of rat pro-atrial natriuretic factor in the circulation: identification, radioimmunoassay and half-life. PubMed ID: 2966345

Occurrence of a novel cardiac natriuretic peptide in rats. PubMed ID: 2525379

Identification of protease 3.4.24.11 as the major atrial natriuretic factor degrading enzyme in the rat kidney. PubMed ID: 2966343

Lack of biologic activity or specific binding of amino-terminal pro-ANP segments in the rat. PubMed ID: 7831500

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction. PubMed ID: 15117952