Details for: Serpine1

Gene ID: 24617

Symbol: Serpine1

Ensembl ID: ENSRNOG00000001414

Description: serpin family E member 1

Associated with

  • Dissolution of fibrin clot
    (R-RNO-75205)
  • Ecm proteoglycans
    (R-RNO-3000178)
  • Extracellular matrix organization
    (R-RNO-1474244)
  • Hemostasis
    (R-RNO-109582)
  • Platelet activation, signaling and aggregation
    (R-RNO-76002)
  • Platelet degranulation
    (R-RNO-114608)
  • Response to elevated platelet cytosolic ca2+
    (R-RNO-76005)
  • Angiogenesis
    (GO:0001525)
  • Cellular response to aldosterone
    (GO:1904045)
  • Cellular response to angiotensin
    (GO:1904385)
  • Cellular response to atp
    (GO:0071318)
  • Cellular response to camp
    (GO:0071320)
  • Cellular response to cgmp
    (GO:0071321)
  • Cellular response to cycloheximide
    (GO:0071409)
  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Cellular response to fibroblast growth factor stimulus
    (GO:0044344)
  • Cellular response to follicle-stimulating hormone stimulus
    (GO:0071372)
  • Cellular response to glucagon stimulus
    (GO:0071377)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to gravity
    (GO:0071258)
  • Cellular response to growth factor stimulus
    (GO:0071363)
  • Cellular response to hydrogen peroxide
    (GO:0070301)
  • Cellular response to hypoxia
    (GO:0071456)
  • Cellular response to insulin stimulus
    (GO:0032869)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to leukemia inhibitory factor
    (GO:1990830)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cellular response to mechanical stimulus
    (GO:0071260)
  • Cellular response to metal ion
    (GO:0071248)
  • Cellular response to nerve growth factor stimulus
    (GO:1990090)
  • Cellular response to nicotine
    (GO:0071316)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Cellular response to platelet-derived growth factor stimulus
    (GO:0036120)
  • Cellular response to potassium ion
    (GO:0035865)
  • Cellular response to resveratrol
    (GO:1904639)
  • Cellular response to transforming growth factor beta stimulus
    (GO:0071560)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Chromaffin granule
    (GO:0042583)
  • Collagen-containing extracellular matrix
    (GO:0062023)
  • Decidualization
    (GO:0046697)
  • Defense response to gram-negative bacterium
    (GO:0050829)
  • Dentinogenesis
    (GO:0097187)
  • Extracellular exosome
    (GO:0070062)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Female gonad development
    (GO:0008585)
  • Mast cell activation
    (GO:0045576)
  • Negative regulation of cell adhesion mediated by integrin
    (GO:0033629)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of endopeptidase activity
    (GO:0010951)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
    (GO:1902042)
  • Negative regulation of fibrinolysis
    (GO:0051918)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of plasminogen activation
    (GO:0010757)
  • Negative regulation of smooth muscle cell-matrix adhesion
    (GO:2000098)
  • Negative regulation of smooth muscle cell migration
    (GO:0014912)
  • Negative regulation of vascular wound healing
    (GO:0061044)
  • Placenta development
    (GO:0001890)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of calcium ion import
    (GO:0090280)
  • Positive regulation of coagulation
    (GO:0050820)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of epithelium regeneration
    (GO:1905043)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of keratinocyte migration
    (GO:0051549)
  • Positive regulation of leukotriene production involved in inflammatory response
    (GO:0035491)
  • Positive regulation of monocyte chemotaxis
    (GO:0090026)
  • Positive regulation of odontoblast differentiation
    (GO:1901331)
  • Positive regulation of receptor-mediated endocytosis
    (GO:0048260)
  • Protease binding
    (GO:0002020)
  • Regulation of angiogenesis
    (GO:0045765)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Replicative senescence
    (GO:0090399)
  • Response to cytokine
    (GO:0034097)
  • Response to epidermal growth factor
    (GO:0070849)
  • Response to estrogen
    (GO:0043627)
  • Response to hyperoxia
    (GO:0055093)
  • Response to laminar fluid shear stress
    (GO:0034616)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to nutrient levels
    (GO:0031667)
  • Response to reactive oxygen species
    (GO:0000302)
  • Response to starvation
    (GO:0042594)
  • Response to transforming growth factor beta
    (GO:0071559)
  • Serine-type endopeptidase inhibitor activity
    (GO:0004867)
  • Signaling receptor binding
    (GO:0005102)
  • Tissue regeneration
    (GO:0042246)

Other Information

Genular Protein ID: 3196539683

Symbol: PAI1_RAT

Name: Plasminogen activator inhibitor 1

UniProtKB Accession Codes:

P20961

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 BindingDB 1 BioGRID 1 CTD 1 ChEMBL 1 EMBL 2 Ensembl 3 GO 87 Gene3D 2 GlyCosmos 1 GlyGen 1 InParanoid 1 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 3 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 UniProtKB 2 eggNOG 1 jPOST 1

Citations:

PubMed ID: 2298740

Title: Isolation and characterization of the rat plasminogen activator inhibitor-1 gene.

PubMed ID: 2298740

DOI: 10.1016/s0021-9258(19)39942-9

PubMed ID: 3149611

Title: Cloning and sequencing of cDNA for the rat plasminogen activator inhibitor-1.

PubMed ID: 3149611

DOI: 10.1016/0378-1119(88)90510-0

PubMed ID: 28722352

Title: Serpine 1 induces alveolar type II cell senescence through activating p53-p21-Rb pathway in fibrotic lung disease.

PubMed ID: 28722352

DOI: 10.1111/acel.12643

Sequence Information:

  • Length: 402
  • Mass: 45010
  • Checksum: 2B639140F475EB53
  • Sequence:
    • MQMSSALTCL TLGLVLVFGK GFASPLPESH TAQQATNFGV KVFQHVVQAS KDRNVVFSPY 
GVSSVLAMLQ LTTAGKTRQQ IQDAMGFNIS ERGTAPALRK LSKELMGSWN KNEISTADAI 
FVQRDLELVQ GFMPHFFKLF RTTVKQVDFS EVERARFIIN DWVERHTKGM ISDLLAKGAV 
NELTRLVLVN ALYFNGQWKT PFLEASTHQR LFHKSDGSTI SVPMMAQNNK FNYTEFTTPD 
GHEYDILELP YHGETLSMFI AAPFEKDVPL SAITNILDAE LIRQWKSNMT RLPRLLILPK 
FSLETEVDLR GPLEKLGMTD IFSSTQADFT SLSDQEQLSV AQALQKVKIE VNESGTVASS 
STAILVSARM APTEMVLDRS FLFVVRHNPT ETILFMGQLM EP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.