Genular: Defining Cellular Identity and Function

Details for: Pde4b

Gene ID: 24626

Symbol: Pde4b

Ensembl ID: ENSRNOG00000005905

Description: phosphodiesterase 4B

Associated with

Darpp-32 events
(R-RNO-180024)
G alpha (i) signalling events
(R-RNO-418594)
Gpcr downstream signalling
(R-RNO-388396)
Opioid signalling
(R-RNO-111885)
Signaling by gpcr
(R-RNO-372790)
3',5'-cyclic-amp phosphodiesterase activity
(GO:0004115)
3',5'-cyclic-gmp phosphodiesterase activity
(GO:0047555)
3',5'-cyclic-nucleotide phosphodiesterase activity
(GO:0004114)
Calcium channel regulator activity
(GO:0005246)
Camp-mediated signaling
(GO:0019933)
Camp binding
(GO:0030552)
Camp catabolic process
(GO:0006198)
Cell periphery
(GO:0071944)
Cellular response to epinephrine stimulus
(GO:0071872)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to xenobiotic stimulus
(GO:0071466)
Centrosome
(GO:0005813)
Cytosol
(GO:0005829)
Dendritic spine
(GO:0043197)
Excitatory synapse
(GO:0060076)
Gamma-tubulin binding
(GO:0043015)
Gamma-tubulin complex
(GO:0000930)
Hydrolase activity
(GO:0016787)
Leukocyte migration
(GO:0050900)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway
(GO:0071878)
Negative regulation of relaxation of cardiac muscle
(GO:1901898)
Neutrophil chemotaxis
(GO:0030593)
Neutrophil homeostasis
(GO:0001780)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of interleukin-2 production
(GO:0032743)
Positive regulation of type ii interferon production
(GO:0032729)
Postsynaptic density
(GO:0014069)
Regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
(GO:1902514)
Regulation of cardiac muscle cell contraction
(GO:0086004)
Signal transduction
(GO:0007165)
Smooth muscle contraction
(GO:0006939)
Synaptic vesicle
(GO:0008021)
T cell receptor signaling pathway
(GO:0050852)
Transmembrane transporter binding
(GO:0044325)
Voltage-gated calcium channel complex
(GO:0005891)
Z disc
(GO:0030018)

Other Information

Proteins

DPDE4

Genular Protein ID: 3016922142

Symbol: PDE4B_RAT

Name: DPDE4

UniProtKB Accession Codes:

P14646 Q5RKL0 Q8VD81 Q8VD82

Database IDs:

Citations:

PubMed ID: 1655746

Title: Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell.

PubMed ID: 1655746

DOI: 10.1016/s0021-9258(18)55280-7

PubMed ID: 7958996

Title: Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases.

PubMed ID: 7958996

DOI: 10.1016/0378-1119(94)90155-4

PubMed ID: 8276818

Title: Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites.

PubMed ID: 8276818

DOI: 10.1016/s0021-9258(17)42355-6

PubMed ID: 9371714

Title: Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3.

PubMed ID: 9371714

DOI: 10.1042/bj3280549

PubMed ID: 12441002

Title: Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform.

PubMed ID: 12441002

DOI: 10.1042/bj20021082

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2542941

Title: Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase.

PubMed ID: 2542941

DOI: 10.1073/pnas.86.10.3599

PubMed ID: 2546153

Title: Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes.

PubMed ID: 2546153

DOI: 10.1073/pnas.86.14.5325

PubMed ID: 19103603

Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.

PubMed ID: 19103603

DOI: 10.1074/jbc.m808394200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 736
Mass: 83375
Checksum: C48F576EFA8DF498
Sequence:

MKKSRSVMAV TADDNLKDYF ECSLSKSYSS SSYTLGIDLW RGRRCCSGNL QLPPLSQRQS 
ERARTPEGDG ISRPTTLPLT TLPSIAITTV SQECFDVENG PSPGRSPLDP QASSSSGLVL 
HAAFPGHSQR RESFLYRSDS DYDLSPKAMS RNSSLPSEQH GDDLIVTPFA QVLASLRIVR 
NNFTLLTNLH GAPNKRSPAA SQAPVTRVSL QEESYQKLAM ETLEELDWCL DQLETIQTYR 
SVSEMASNKF KRMLNRELTH LSEMSRSGNQ VSEYISNTFL DKQNDVEIPS PTQKDREKKK 
KQQLMTQISG VKKLMHSSSL NNTSISRFGV NTENEDHLAK ELEDLNKWGL NIFNVAGYSH 
NRPLTCIMYA IFQERDLLKT FKISSDTFVT YMMTLEDHYH SDVAYHNSLH AADVAQSTHV 
LLSTPALDAV FTDLEILAAI FAAAIHDVDH PGVSNQFLIN TNSELALMYN DESVLENHHL 
AVGFKLLQEE HCDIFQNLTK KQRQTLRKMV IDMVLATDMS KHMSLLADLK TMVETKKVTS 
SGVLLLDNYT DRIQVLRNMV HCADLSNPTK SLELYRQWTD RIMEEFFQQG DKERERGMEI 
SPMCDKHTAS VEKSQVGFID YIVHPLWETW ADLVQPDAQD ILDTLEDNRN WYQSMIPQSP 
SPPLDERSRD CQGLMEKFQF ELTLEEEDSE GPEKEGEGPN YFSSTKTLCV IDPENRDSLE 
ETDIDIATED KSLIDT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pde4b

Associated with

Other Information

Properties and hormonal regulation of two structurally related cAMP phosphodiesterases from the rat Sertoli cell. PubMed ID: 1655746

Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases. PubMed ID: 7958996

Structure of two rat genes coding for closely related rolipram-sensitive cAMP phosphodiesterases. Multiple mRNA variants originate from alternative splicing and multiple start sites. PubMed ID: 8276818

Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3. PubMed ID: 9371714

Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. PubMed ID: 12441002

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. PubMed ID: 2542941

Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes. PubMed ID: 2546153

Night/day changes in pineal expression of &gt;600 genes: central role of adrenergic/cAMP signaling. PubMed ID: 19103603

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903