Genular: Defining Cellular Identity and Function

Details for: Pdgfb

Gene ID: 24628

Symbol: Pdgfb

Ensembl ID: ENSRNOG00000017197

Description: platelet derived growth factor subunit B

Associated with

Downstream signal transduction
(R-RNO-186763)
Hemostasis
(R-RNO-109582)
Intracellular signaling by second messengers
(R-RNO-9006925)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Raf/map kinase cascade
(R-RNO-5673001)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Signaling by pdgf
(R-RNO-186797)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Actin cytoskeleton organization
(GO:0030036)
Blood vessel development
(GO:0001568)
Blood vessel morphogenesis
(GO:0048514)
Branching involved in salivary gland morphogenesis
(GO:0060445)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cell projection assembly
(GO:0030031)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Chemoattractant activity
(GO:0042056)
Collagen binding
(GO:0005518)
Embryonic placenta development
(GO:0001892)
Endothelial cell proliferation
(GO:0001935)
Eye photoreceptor cell development
(GO:0042462)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Fibroblast migration
(GO:0010761)
Gene expression
(GO:0010467)
Glial cell development
(GO:0021782)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Hemopoiesis
(GO:0030097)
Identical protein binding
(GO:0042802)
Interleukin-18-mediated signaling pathway
(GO:0035655)
Male gonad development
(GO:0008584)
Monocyte chemotaxis
(GO:0002548)
Myoblast proliferation
(GO:0051450)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of phosphatidylinositol biosynthetic process
(GO:0010512)
Negative regulation of platelet activation
(GO:0010544)
Neuron remodeling
(GO:0016322)
Paracrine signaling
(GO:0038001)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Platelet-derived growth factor binding
(GO:0048407)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive chemotaxis
(GO:0050918)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of fibroblast growth factor receptor signaling pathway
(GO:0045743)
Positive regulation of fibroblast migration
(GO:0010763)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glomerular filtration
(GO:0003104)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
(GO:0035793)
Positive regulation of mitotic cell cycle, embryonic
(GO:0045977)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Regulation of cell population proliferation
(GO:0042127)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Response to axon injury
(GO:0048678)
Response to estradiol
(GO:0032355)
Response to estrogen
(GO:0043627)
Response to human chorionic gonadotropin
(GO:0044752)
Response to hypoxia
(GO:0001666)
Response to insulin
(GO:0032868)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to wounding
(GO:0009611)
Response to xenobiotic stimulus
(GO:0009410)
Retina development in camera-type eye
(GO:0060041)
Signaling receptor binding
(GO:0005102)
Substrate-dependent cell migration
(GO:0006929)
Superoxide-generating nadph oxidase activator activity
(GO:0016176)
Synapse assembly
(GO:0007416)

Other Information

Proteins

Platelet-derived growth factor subunit B
A0A221LG85_RAT

Genular Protein ID: 870695128

Symbol: PDGFB_RAT

Name: Platelet-derived growth factor subunit B

UniProtKB Accession Codes:

Q05028

Database IDs:

Citations:

PubMed ID: 8318539

Title: Conservation in sequence and affinity of human and rodent PDGF ligands and receptors.

PubMed ID: 8318539

DOI: 10.1016/0167-4781(93)90127-y

PubMed ID: 7758166

Title: A subpopulation of smooth muscle cells in injured rat arteries expresses platelet-derived growth factor-B chain mRNA.

PubMed ID: 7758166

DOI: 10.1161/01.res.76.6.951

Sequence Information:

Length: 225
Mass: 25603
Checksum: 0DAE138B0AA70F0F
Sequence:

LPLCCYLRLV SAEGDPIPEE LYEMLSDHSI RSFDDLQRLL HRDSVDEDGA ELDLNMTRAH 
SGVESESSSR GRRSLGSLAA AEPAVIAECK TRTEVFQISR NLIDRTNANF LVWPPCVEVQ 
RCSGCCNNRN VQCRASQVQM RPVQVRKIEI VRKKPVFKKA TVTLEDHLAC KCETVVTPRP 
VTRSPGTSRE HRAKTPQTRV TVRTVRIRRP PKGKHRKFKH THDKK

Genular Protein ID: 3834606079

Symbol: A0A221LG85_RAT

Name: N/A

UniProtKB Accession Codes:

A0A221LG85

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 241
Mass: 27422
Checksum: 593F9CB4D2748CED
Sequence:

MNRCWALFLP LCCYLRLVSA EGDPIPEELY EMLSDHSIRS FDDLQRLLHR DSVDEDGAEL 
DLNMTRAHSG VESESSSRGR RSLGSLAAAE PAVIAECKTR TEVFQISRNL IDRTNANFLV 
WPPCVEVQRC SGCCNNRNVQ CRASQVQMRP VQVRKIEIVR KKPVFKKATV TLEDHLACKC 
ETVVTPRPVT RSPGTSREHR AKTPQTRVTV RTVRIRRPPK GKHRKFKHTH DKKALKEILG 
A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.