Genular: Defining Cellular Identity and Function

Details for: Pdgfrb

Gene ID: 24629

Symbol: Pdgfrb

Ensembl ID: ENSRNOG00000018461

Description: platelet derived growth factor receptor beta

Associated with

Downstream signal transduction
(R-RNO-186763)
Intracellular signaling by second messengers
(R-RNO-9006925)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Negative regulation of the pi3k/akt network
(R-RNO-199418)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-RNO-6811558)
Pip3 activates akt signaling
(R-RNO-1257604)
Raf/map kinase cascade
(R-RNO-5673001)
Signaling by pdgf
(R-RNO-186797)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Adrenal gland development
(GO:0030325)
Angiogenesis
(GO:0001525)
Animal organ development
(GO:0048513)
Aorta morphogenesis
(GO:0035909)
Atp binding
(GO:0005524)
Blood vessel development
(GO:0001568)
Cardiac myofibril assembly
(GO:0055003)
Cell chemotaxis
(GO:0060326)
Cell migration involved in coronary angiogenesis
(GO:0060981)
Cell migration involved in vasculogenesis
(GO:0035441)
Cellular response to growth factor stimulus
(GO:0071363)
Cellular response to hydrogen peroxide
(GO:0070301)
Chemotaxis
(GO:0006935)
Embryonic organ development
(GO:0048568)
Enzyme binding
(GO:0019899)
Glycosaminoglycan biosynthetic process
(GO:0006024)
Hemopoiesis
(GO:0030097)
Inner ear development
(GO:0048839)
Intracellular signal transduction
(GO:0035556)
In utero embryonic development
(GO:0001701)
Kidney development
(GO:0001822)
Kinase activity
(GO:0016301)
Lung growth
(GO:0060437)
Male gonad development
(GO:0008584)
Metal ion binding
(GO:0046872)
Metanephric glomerular capillary formation
(GO:0072277)
Metanephric glomerular mesangial cell proliferation involved in metanephros development
(GO:0072262)
Metanephric glomerular mesangium development
(GO:0072223)
Metanephric glomerulus morphogenesis
(GO:0072275)
Metanephric mesenchymal cell migration
(GO:0035789)
Metanephric mesenchyme development
(GO:0072075)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Nitrogen compound metabolic process
(GO:0006807)
Phosphatidylinositol 3-kinase binding
(GO:0043548)
Phosphatidylinositol metabolic process
(GO:0046488)
Phosphorylation
(GO:0016310)
Platelet-derived growth factor beta-receptor activity
(GO:0005019)
Platelet-derived growth factor binding
(GO:0048407)
Platelet-derived growth factor receptor-beta signaling pathway
(GO:0035791)
Platelet-derived growth factor receptor activity
(GO:0005017)
Platelet-derived growth factor receptor binding
(GO:0005161)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cell proliferation by vegf-activated platelet derived growth factor receptor signaling pathway
(GO:0038091)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway
(GO:0035793)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Response to estradiol
(GO:0032355)
Response to estrogen
(GO:0043627)
Response to fluid shear stress
(GO:0034405)
Response to hydrogen peroxide
(GO:0042542)
Response to hyperoxia
(GO:0055093)
Response to lipid
(GO:0033993)
Response to organic cyclic compound
(GO:0014070)
Response to retinoic acid
(GO:0032526)
Response to toxic substance
(GO:0009636)
Retina vasculature development in camera-type eye
(GO:0061298)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Skeletal system morphogenesis
(GO:0048705)
Smooth muscle cell chemotaxis
(GO:0071670)
Smooth muscle tissue development
(GO:0048745)
Tissue homeostasis
(GO:0001894)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Vascular endothelial growth factor binding
(GO:0038085)

Other Information

Proteins

Platelet-derived growth factor receptor beta

Genular Protein ID: 943187276

Symbol: PGFRB_RAT

Name: Platelet-derived growth factor receptor beta

UniProtKB Accession Codes:

Q05030 Q8R406 Q925F7

Database IDs:

Citations:

PubMed ID: 8318539

Title: Conservation in sequence and affinity of human and rodent PDGF ligands and receptors.

PubMed ID: 8318539

DOI: 10.1016/0167-4781(93)90127-y

PubMed ID: 11346654

Title: Regulation of cell growth by redox-mediated extracellular proteolysis of platelet-derived growth factor receptor beta.

PubMed ID: 11346654

DOI: 10.1074/jbc.m102995200

Sequence Information:

Length: 1097
Mass: 122828
Checksum: 5E6540FA0C5CF22B
Sequence:

MGLPEVMPAS VLRGQLLLFV LLLLGPQISQ GLVITPPGPE FVLNISSTFV LTCSSSAPVM 
WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV YNNSLGPELS ERKRIYIFVP 
DPTMGFLPMD SEDLFIFVTD VTETTIPCRV TDPQLEVTLH EKKVDIPLHV PYDHQRGFIG 
TFEDKTYICK TTIGDREVDS DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND 
VVNFQWTYPR MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG 
DEKAINVTVI ENGYVRLLET LEDVQIAELH RSRTLQVVFE AYPTPSVLWF KDNRTLGDSS 
AGELVLSTRN VSETRYVSEL TLVRVKVSEA GYYTMRAFHA DDQVQLSFKL QVNVPVRVLE 
LSESHPANGE QILRCRGRGM PQPNVTWSTC RDLKRCPRKL SPTPLGNSSK EESQLETNVT 
FWEEDQEYEV VSTLRLRHVD QPLSVRCMLQ NSMGRDSQEV TVVPHSLPFK VVVISAILAL 
VVLTVISLII LIMLWQRKPR YEIRWKVIES VSSDGHEYIY VDPVQLPYDS TWELPRDQLV 
LGRTLGSGAF GQVVEATAHG LSHSQATMKV AVKMLKSTAR SSEKQALMSE LKIMSHLGPH 
LNVVNLLGAC TKGGPIYIIT EYCRYGDLVD YLHRNKHTFL QRHSNKHCPP STELYSNALP 
VGLSLPSHLN LTGESDGGYM DMSKDESVDY VPMLDMKGHI KYADIESSSY MAPYDNYVPS 
APERTYRATL INDSPVLSYT DLVGFSYQVA NGMEFLASKN CVHRDLAARN VLICEGKLVK 
ICDFGLARDI MRDSNYISKG STFLPLKWMA PESIFNSLYT TLSDVWSFGI LLWEIFTLGG 
TPYPELPMND QFYNAIKRGY RMAQPAHASD EIYEIMQKCW EEKFETRPPF SQLVLLLERL 
LGEGYKKKYQ QVDEEFLRSD HPAILRSQAR LPGLHSLRSP LDTSSVLYTA VQPNETDNDY 
IIPLPDPKPD AADEGLLEGS PSLASSTLNE VNTSSTISCD SPLELQEEPQ AEPEAQLEQP 
QDSGCPGPLA EAEDSFL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.