Details for: Pfkfb1

Gene ID: 24638

Symbol: Pfkfb1

Ensembl ID: ENSRNOG00000000165

Description: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Associated with

Other Information

Genular Protein ID: 3828282123

Symbol: F261_RAT

Name: 6PF-2-K/Fru-2,6-P2ase liver isozyme

UniProtKB Accession Codes:

P07953 P16119

Database IDs:

AGR 1 AlphaFoldDB 1 BMRB 1 BRENDA 2 Bgee 1 CDD 1 CTD 1 ChEBI 31 ComplexPortal 1 EC 2 EMBL 7 Ensembl 4 EvolutionaryTrace 1 ExpressionAtlas 1 GO 18 Gene3D 2 GeneTree 1 Genevisible 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 5 PIR 1 PIRSF 1 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 2 Reactome 1 RefSeq 1 Rhea 4 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UniProtKB 2 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 2856848

Title: Complete nucleotide sequence coding for rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase derived from a cDNA clone.

PubMed ID: 2856848

DOI: 10.1016/0014-5793(87)80476-3

PubMed ID: 3032183

Title: Isolation of a cDNA clone for rat liver 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase.

PubMed ID: 3032183

DOI: 10.1016/0006-291x(87)90364-0

PubMed ID: 2547611

Title: Characterization of distinct mRNAs coding for putative isozymes of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 2547611

DOI: 10.1111/j.1432-1033.1989.tb14946.x

PubMed ID: 2848802

Title: Induction of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase mRNA by refeeding and insulin.

PubMed ID: 2848802

DOI: 10.1016/s0021-9258(18)37337-x

PubMed ID: 2826464

Title: Complete amino acid sequence of rat liver 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 2826464

DOI: 10.1016/s0021-9258(19)35431-6

PubMed ID: 2557826

Title: Cloning and expression in Escherichia coli of a rat hepatoma cell cDNA coding for 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 2557826

DOI: 10.1042/bj2640151

PubMed ID: 3040762

Title: Active site sequence of hepatic fructose-2,6-bisphosphatase. Homology in primary structure with phosphoglycerate mutase.

PubMed ID: 3040762

DOI: 10.1016/s0021-9258(18)45259-3

PubMed ID: 2549541

Title: 5' flanking sequence and structure of a gene encoding rat 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 2549541

DOI: 10.1073/pnas.86.17.6543

PubMed ID: 2539378

Title: Catalytic site of rat liver and bovine heart fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase. Identification of fructose 6-phosphate binding site.

PubMed ID: 2539378

DOI: 10.1016/s0021-9258(18)83354-3

PubMed ID: 2557623

Title: Evolution of a bifunctional enzyme: 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

PubMed ID: 2557623

DOI: 10.1073/pnas.86.24.9642

PubMed ID: 7549867

Title: Covalent control of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase: insights into autoregulation of a bifunctional enzyme.

PubMed ID: 7549867

DOI: 10.1002/pro.5560040601

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 8634242

Title: Crystal structure of the rat liver fructose-2,6-bisphosphatase based on selenomethionine multiwavelength anomalous dispersion phases.

PubMed ID: 8634242

DOI: 10.1021/bi9600613

PubMed ID: 9253407

Title: Crystal structure of a trapped phosphoenzyme during a catalytic reaction.

PubMed ID: 9253407

DOI: 10.1038/nsb0897-615

Sequence Information:

  • Length: 471
  • Mass: 54763
  • Checksum: E307AF13945E0FCD
  • Sequence:
    • MSREMGELTQ TRLQKIWIPH SSSSSVLQRR RGSSIPQFTN SPTMVIMVGL PARGKTYIST 
KLTRYLNWIG TPTKVFNLGQ YRREAVSYRN YEFFRPDNTE AQLIRKQCAL AALKDVHKYL 
SREEGHVAVF DATNTTRERR SLILQFAKEH GYKVFFIESI CNDPEIIAEN IKQVKLGSPD 
YIDCDQEKVL EDFLKRIECY EINYQPLDEE LDSHLSYIKI FDVGTRYMVN RVQDHVQSRT 
AYYLMNIHVT PRSIYLCRHG ESELNLRGRI GGDSGLSARG KQYAYALANF IRSQGISSLK 
VWTSHMKRTI QTAEALGVPY EQWKALNEID AGVCEEMTYE EIQEHYPEEF ALRDQDKYRY 
RYPKGESYED LVQRLEPVIM ELERQENVLV ICHQAVMRCL LAYFLDKSSD ELPYLKCPLH 
TVLKLTPVAY GCRVESIYLN VEAVNTHRDK PENVDITREA EEALDTVPAH Y

Genular Protein ID: 1598682312

Symbol: A0A0H2UH89_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0H2UH89

Database IDs:

ARBA 7 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 1 Pfam 2 Proteomes 2 RGD 2 RefSeq 3 SMART 1 SMR 1 SUPFAM 2

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

Sequence Information:

  • Length: 469
  • Mass: 54164
  • Checksum: 0E5225C2520D50E2
  • Sequence:
    • MPPTGPALGV CKCKRAIGKL AMEEKASKRT ASIPQFTNSP TMVIMVGLPA RGKTYISTKL 
TRYLNWIGTP TKVFNLGQYR REAVSYRNYE FFRPDNTEAQ LIRKQCALAA LKDVHKYLSR 
EEGHVAVFDA TNTTRERRSL ILQFAKEHGY KVFFIESICN DPEIIAENIK QVKLGSPDYI 
DCDQEKVLED FLKRIECYEI NYQPLDEELD SHLSYIKIFD VGTRYMVNRV QDHVQSRTAY 
YLMNIHVTPR SIYLCRHGES ELNLRGRIGG DSGLSARGKQ YAYALANFIR SQGISSLKVW 
TSHMKRTIQT AEALGVPYEQ WKALNEIDAG VCEEMTYEEI QEHYPEEFAL RDQDKYRYRY 
PKGESYEDLV QRLEPVIMEL ERQENVLVIC HQAVMRCLLA YFLDKSSDEL PYLKCPLHTV 
LKLTPVAYGC RVESIYLNVE AVNTHRDKPE NVDITREAEE ALDTVPAHY

Genular Protein ID: 3461652693

Symbol: A0A0G2K0S8_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0G2K0S8

Database IDs:

ARBA 7 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 Ensembl 2 ExpressionAtlas 1 GO 5 Gene3D 2 GeneTree 1 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PIRSR 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 3 Proteomes 2 RGD 2 RefSeq 2 SMART 1 SMR 1 SUPFAM 2 jPOST 1

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

Sequence Information:

  • Length: 427
  • Mass: 49527
  • Checksum: C7FC541C8CFBC7FF
  • Sequence:
    • MPPTGPALGV CKCKRAIGKL AMEEKASKRT VFNLGQYRRE AVSYRNYEFF RPDNTEAQLI 
RKQCALAALK DVHKYLSREE GHVAVFDATN TTRERRSLIL QFAKEHGYKV FFIESICNDP 
EIIAENIKQV KLGSPDYIDC DQEKVLEDFL KRIECYEINY QPLDEELDSH LSYIKIFDVG 
TRYMVNRVQD HVQSRTAYYL MNIHVTPRSI YLCRHGESEL NLRGRIGGDS GLSARGKQYA 
YALANFIRSQ GISSLKVWTS HMKRTIQTAE ALGVPYEQWK ALNEIDAGVC EEMTYEEIQE 
HYPEEFALRD QDKYRYRYPK GESYEDLVQR LEPVIMELER QENVLVICHQ AVMRCLLAYF 
LDKSSDELPY LKCPLHTVLK LTPVAYGCRV ESIYLNVEAV NTHRDKPENV DITREAEEAL 
DTVPAHY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.