Genular: Defining Cellular Identity and Function

Details for: Pmch

Gene ID: 24659

Symbol: Pmch

Ensembl ID: ENSRNOG00000066777

Description: pro-melanin-concentrating hormone

Associated with

Class a/1 (rhodopsin-like receptors)
(R-RNO-373076)
G alpha (i) signalling events
(R-RNO-418594)
G alpha (q) signalling events
(R-RNO-416476)
Gpcr downstream signalling
(R-RNO-388396)
Gpcr ligand binding
(R-RNO-500792)
Peptide ligand-binding receptors
(R-RNO-375276)
Signaling by gpcr
(R-RNO-372790)
Behavior
(GO:0007610)
Chemical synaptic transmission
(GO:0007268)
Drinking behavior
(GO:0042756)
Extracellular space
(GO:0005615)
Feeding behavior
(GO:0007631)
Lactation
(GO:0007595)
Learning or memory
(GO:0007611)
Melanin-concentrating hormone activity
(GO:0030354)
Negative regulation of blood pressure
(GO:0045776)
Negative regulation of synaptic transmission, dopaminergic
(GO:0032227)
Neuropeptide signaling pathway
(GO:0007218)
Nucleus
(GO:0005634)
Positive regulation of circadian sleep/wake cycle, rem sleep
(GO:0046005)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Regulation of heart rate
(GO:0002027)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Signal transduction
(GO:0007165)
Synapse
(GO:0045202)
Type 1 melanin-concentrating hormone receptor binding
(GO:0031777)

Other Information

Proteins

Pro-MCH

Genular Protein ID: 739363193

Symbol: MCH_RAT

Name: Pro-MCH

UniProtKB Accession Codes:

P14200

Database IDs:

Citations:

PubMed ID: 2477226

Title: The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus.

PubMed ID: 2477226

DOI: 10.1210/endo-125-4-2056

PubMed ID: 2261081

Title: Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene.

PubMed ID: 2261081

DOI: 10.1089/dna.1990.9.637

PubMed ID: 2759038

Title: Characterization of melanin-concentrating hormone from rat hypothalamus.

PubMed ID: 2759038

DOI: 10.1210/endo-125-3-1660

PubMed ID: 7783849

Title: Pro-melanin concentrating hormone messenger ribonucleic acid and peptides expression in peripheral tissues of the rat.

PubMed ID: 7783849

DOI: 10.1159/000126857

PubMed ID: 8593803

Title: Similarities in cellular expression and functions of melanin-concentrating hormone and atrial natriuretic factor in the rat digestive tract.

PubMed ID: 8593803

DOI: 10.1210/endo.137.2.8593803

PubMed ID: 7617126

Title: Melanin-concentrating hormone in human and rat.

PubMed ID: 7617126

DOI: 10.1159/000126872

PubMed ID: 1327720

Title: Secretion of melanin-concentrating hormone and neuropeptide-EI from cultured rat hypothalamic cells.

PubMed ID: 1327720

DOI: 10.1210/endo.131.4.1327720

PubMed ID: 10037747

Title: Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals.

PubMed ID: 10037747

DOI: 10.1074/jbc.274.10.6536

PubMed ID: 7647772

Title: Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat.

PubMed ID: 7647772

DOI: 10.1111/j.1365-2826.1995.tb00761.x

PubMed ID: 9700748

Title: Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with alpha-MSH, MCH and dopamine.

PubMed ID: 9700748

DOI: 10.1016/s0196-9781(98)00045-x

PubMed ID: 9809645

Title: Melanocortin and MCH precursor-derived NEI effects on striatum-midbrain co-cultures.

PubMed ID: 9809645

DOI: 10.1016/s0196-9781(98)00076-x

Sequence Information:

Length: 165
Mass: 18482
Checksum: 38E9F07693E77A05
Sequence:

MAKMSLSSYM LMLAFSLFSH GILLSASKSI RNVEDDIVFN TFRMGKAFQK EDTAERSVVA 
PSLEGYKNDE SGFMKDDDDK TTKNTGSKQN LVTHGLPLSL AVKPYLALKG PAVFPAENGV 
QNTESTQEKR EIGDEENSAK FPIGRRDFDM LRCMLGRVYR PCWQV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Pmch

Associated with

Other Information

The rat melanin-concentrating hormone messenger ribonucleic acid encodes multiple putative neuropeptides coexpressed in the dorsolateral hypothalamus. PubMed ID: 2477226

Nucleotide sequence and tissue-specific expression of the rat melanin concentrating hormone gene. PubMed ID: 2261081

Characterization of melanin-concentrating hormone from rat hypothalamus. PubMed ID: 2759038

Pro-melanin concentrating hormone messenger ribonucleic acid and peptides expression in peripheral tissues of the rat. PubMed ID: 7783849

Similarities in cellular expression and functions of melanin-concentrating hormone and atrial natriuretic factor in the rat digestive tract. PubMed ID: 8593803

Melanin-concentrating hormone in human and rat. PubMed ID: 7617126

Secretion of melanin-concentrating hormone and neuropeptide-EI from cultured rat hypothalamic cells. PubMed ID: 1327720

Cellular localization and role of prohormone convertases in the processing of pro-melanin concentrating hormone in mammals. PubMed ID: 10037747

Neuropeptide-E-I antagonizes the action of melanin-concentrating hormone on stress-induced release of adrenocorticotropin in the rat. PubMed ID: 7647772

Behavioral effects of neuropeptide E-I (NEI) in the female rat: interactions with alpha-MSH, MCH and dopamine. PubMed ID: 9700748

Melanocortin and MCH precursor-derived NEI effects on striatum-midbrain co-cultures. PubMed ID: 9809645