Genular: Defining Cellular Identity and Function

Details for: Ppp3ca

Gene ID: 24674

Symbol: Ppp3ca

Ensembl ID: ENSRNOG00000009882

Description: protein phosphatase 3 catalytic subunit alpha

Associated with

Adaptive immune system
(R-RNO-1280218)
Beta-catenin independent wnt signaling
(R-RNO-3858494)
C-type lectin receptors (clrs)
(R-RNO-5621481)
Ca2+ pathway
(R-RNO-4086398)
Calcineurin activates nfat
(R-RNO-2025928)
Clec7a (dectin-1) induces nfat activation
(R-RNO-5607763)
Clec7a (dectin-1) signaling
(R-RNO-5607764)
Downstream signaling events of b cell receptor (bcr)
(R-RNO-1168372)
Fc epsilon receptor (fceri) signaling
(R-RNO-2454202)
Fceri mediated ca+2 mobilization
(R-RNO-2871809)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Signaling by the b cell receptor (bcr)
(R-RNO-983705)
Signaling by wnt
(R-RNO-195721)
Signal transduction
(R-RNO-162582)
Atpase binding
(GO:0051117)
Calcineurin-mediated signaling
(GO:0097720)
Calcineurin-nfat signaling cascade
(GO:0033173)
Calcineurin complex
(GO:0005955)
Calcium-dependent protein serine/threonine phosphatase activity
(GO:0004723)
Calcium-mediated signaling
(GO:0019722)
Calcium ion transport
(GO:0006816)
Calmodulin-dependent protein phosphatase activity
(GO:0033192)
Calmodulin binding
(GO:0005516)
Cardiac muscle hypertrophy in response to stress
(GO:0014898)
Cellular response to glucose stimulus
(GO:0071333)
Cyclosporin a binding
(GO:0016018)
Cytoplasm
(GO:0005737)
Cytoplasmic side of plasma membrane
(GO:0009898)
Cytosol
(GO:0005829)
Dendrite morphogenesis
(GO:0048813)
Dendritic spine
(GO:0043197)
Dephosphorylation
(GO:0016311)
Enzyme binding
(GO:0019899)
Epidermis development
(GO:0008544)
Excitatory postsynaptic potential
(GO:0060079)
G1/s transition of mitotic cell cycle
(GO:0000082)
Glutamatergic synapse
(GO:0098978)
Keratinocyte differentiation
(GO:0030216)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Modulation of chemical synaptic transmission
(GO:0050804)
Multicellular organismal response to stress
(GO:0033555)
Myosin phosphatase activity
(GO:0017018)
Negative regulation of angiotensin-activated signaling pathway
(GO:0110062)
Negative regulation of calcium ion-dependent exocytosis
(GO:0045955)
Negative regulation of dendrite morphogenesis
(GO:0050774)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of insulin secretion
(GO:0046676)
Negative regulation of signaling
(GO:0023057)
Nucleus
(GO:0005634)
Phosphoprotein phosphatase activity
(GO:0004721)
Plasma membrane
(GO:0005886)
Positive regulation of activated t cell proliferation
(GO:0042104)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cardiac muscle hypertrophy in response to stress
(GO:1903244)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of connective tissue replacement
(GO:1905205)
Positive regulation of endocytosis
(GO:0045807)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glomerulus development
(GO:0090193)
Positive regulation of osteoblast differentiation
(GO:0045669)
Positive regulation of osteoclast differentiation
(GO:0045672)
Positive regulation of saliva secretion
(GO:0046878)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Postsynapse
(GO:0098794)
Postsynaptic modulation of chemical synaptic transmission
(GO:0099170)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein import into nucleus
(GO:0006606)
Protein serine/threonine phosphatase activity
(GO:0004722)
Regulation of cell proliferation involved in kidney morphogenesis
(GO:0061006)
Renal filtration
(GO:0097205)
Response to amphetamine
(GO:0001975)
Response to calcium ion
(GO:0051592)
Sarcolemma
(GO:0042383)
Schaffer collateral - ca1 synapse
(GO:0098685)
Skeletal muscle fiber development
(GO:0048741)
Slit diaphragm
(GO:0036057)
Synapse
(GO:0045202)
Transition between fast and slow fiber
(GO:0014883)
Z disc
(GO:0030018)

Other Information

Proteins

CAM-PRP catalytic subunit

Genular Protein ID: 735076314

Symbol: PP2BA_RAT

Name: CAM-PRP catalytic subunit

UniProtKB Accession Codes:

P63329 P12816 P20652 Q6LDJ8 Q9WUV7 Q9Z1I5

Database IDs:

Citations:

PubMed ID: 2551293

Title: The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A.

PubMed ID: 2551293

DOI: 10.1016/0006-291x(89)91148-0

PubMed ID: 1322410

Title: Characterization of the phosphatase activity of a baculovirus-expressed calcineurin A isoform.

PubMed ID: 1322410

DOI: 10.1016/s0021-9258(19)49628-2

PubMed ID: 1335233

Title: Molecular cloning and characterization of the promoter region of the calcineurin A alpha gene.

PubMed ID: 1335233

DOI: 10.1042/bj2880801

PubMed ID: 2174876

Title: Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells.

PubMed ID: 2174876

DOI: 10.1016/s0021-9258(18)45767-5

PubMed ID: 10593895

Title: Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein.

PubMed ID: 10593895

DOI: 10.1074/jbc.274.51.36125

PubMed ID: 11114196

Title: Calsarcins, a novel family of sarcomeric calcineurin-binding proteins.

PubMed ID: 11114196

DOI: 10.1073/pnas.260501097

PubMed ID: 18815128

Title: CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells.

PubMed ID: 18815128

DOI: 10.1074/jbc.m806684200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 23699505

Title: Balance of calcineurin Aalpha and CDK5 activities sets release probability at nerve terminals.

PubMed ID: 23699505

DOI: 10.1523/jneurosci.4288-12.2013

PubMed ID: 24018048

Title: Structural basis of calcineurin activation by calmodulin.

PubMed ID: 24018048

DOI: 10.1016/j.cellsig.2013.08.033

Sequence Information:

Length: 521
Mass: 58644
Checksum: 16530C27DDBF1F05
Sequence:

MSEPKAIDPK LSTTDRVVKA VPFPPSHRLT AKEVFDNDGK PRVDILKAHL MKEGRLEESV 
ALRIITEGAS ILRQEKNLLD IDAPVTVCGD IHGQFFDLMK LFEVGGSPAN TRYLFLGDYV 
DRGYFSIECV LYLWALKILY PKTLFLLRGN HECRHLTEYF TFKQECKIKY SERVYDACMD 
AFDCLPLAAL MNQQFLCVHG GLSPEINTLD DIRKLDRFKE PPAYGPMCDI LWSDPLEDFG 
NEKTQEHFTH NTVRGCSYFY SYPAVCDFLQ HNNLLSILRA HEAQDAGYRM YRKSQTTGFP 
SLITIFSAPN YLDVYNNKAA VLKYENNVMN IRQFNCSPHP YWLPNFMDVF TWSLPFVGEK 
VTEMLVNVLN ICSDDELGSE EDGFDGATAA ARKEVIRNKI RAIGKMARVF SVLREESESV 
LTLKGLTPTG MLPSGVLSGG KQTLQSATVE AIEADEAIKG FSPQHKITSF EEAKGLDRIN 
ERMPPRRDAM PSDANLNSIN KALASETNGT DSNGSNSSNI Q

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp3ca

Associated with

Other Information

The complete primary structure of calcineurin A, a calmodulin binding protein homologous with protein phosphatases 1 and 2A. PubMed ID: 2551293

Characterization of the phosphatase activity of a baculovirus-expressed calcineurin A isoform. PubMed ID: 1322410

Molecular cloning and characterization of the promoter region of the calcineurin A alpha gene. PubMed ID: 1335233

Multiplicity of protein serine-threonine phosphatases in PC12 pheochromocytoma and FTO-2B hepatoma cells. PubMed ID: 2174876

Inhibition of calcineurin phosphatase activity by a calcineurin B homologous protein. PubMed ID: 10593895

Calsarcins, a novel family of sarcomeric calcineurin-binding proteins. PubMed ID: 11114196

CHP2 activates the calcineurin/nuclear factor of activated T cells signaling pathway and enhances the oncogenic potential of HEK293 cells. PubMed ID: 18815128

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Balance of calcineurin Aalpha and CDK5 activities sets release probability at nerve terminals. PubMed ID: 23699505

Structural basis of calcineurin activation by calmodulin. PubMed ID: 24018048