Genular: Defining Cellular Identity and Function

Details for: Prnp

Gene ID: 24686

Symbol: Prnp

Ensembl ID: ENSRNOG00000021259

Description: prion protein

Associated with

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
(R-RNO-9609523)
Protein localization
(R-RNO-9609507)
Amyloid-beta binding
(GO:0001540)
Amyloid precursor protein metabolic process
(GO:0042982)
Aspartic-type endopeptidase inhibitor activity
(GO:0019828)
Atp-dependent protein binding
(GO:0043008)
Calcium-mediated signaling using intracellular calcium source
(GO:0035584)
Cell surface
(GO:0009986)
Cellular response to amyloid-beta
(GO:1904646)
Cellular response to copper ion
(GO:0071280)
Cellular response to xenobiotic stimulus
(GO:0071466)
Copper ion binding
(GO:0005507)
Cupric ion binding
(GO:1903135)
Cuprous ion binding
(GO:1903136)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Endoplasmic reticulum
(GO:0005783)
Glycosaminoglycan binding
(GO:0005539)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Inclusion body
(GO:0016234)
Intracellular membrane-bounded organelle
(GO:0043231)
Lamin binding
(GO:0005521)
Learning or memory
(GO:0007611)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Microtubule binding
(GO:0008017)
Mitochondrial outer membrane
(GO:0005741)
Molecular adaptor activity
(GO:0060090)
Molecular condensate scaffold activity
(GO:0140693)
Molecular function activator activity
(GO:0140677)
Negative regulation of activated t cell proliferation
(GO:0046007)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of amyloid precursor protein catabolic process
(GO:1902992)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of calcineurin-nfat signaling cascade
(GO:0070885)
Negative regulation of dendritic spine maintenance
(GO:1902951)
Negative regulation of interleukin-2 production
(GO:0032703)
Negative regulation of interleukin-17 production
(GO:0032700)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of t cell receptor signaling pathway
(GO:0050860)
Negative regulation of type ii interferon production
(GO:0032689)
Neuron projection maintenance
(GO:1990535)
Nuclear membrane
(GO:0031965)
Plasma membrane
(GO:0005886)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of protein targeting to membrane
(GO:0090314)
Postsynaptic density
(GO:0014069)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein-folding chaperone binding
(GO:0051087)
Protein destabilization
(GO:0031648)
Protein homooligomerization
(GO:0051260)
Protein sequestering activity
(GO:0140311)
Regulation of calcium ion import across plasma membrane
(GO:1905664)
Regulation of glutamate receptor signaling pathway
(GO:1900449)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of potassium ion transmembrane transport
(GO:1901379)
Regulation of protein localization
(GO:0032880)
Response to amyloid-beta
(GO:1904645)
Response to cadmium ion
(GO:0046686)
Response to copper ion
(GO:0046688)
Response to oxidative stress
(GO:0006979)
Side of membrane
(GO:0098552)
Signaling receptor activity
(GO:0038023)
Terminal bouton
(GO:0043195)
Transmembrane transporter binding
(GO:0044325)
Tubulin binding
(GO:0015631)
Type 5 metabotropic glutamate receptor binding
(GO:0031802)
Type 8 metabotropic glutamate receptor binding
(GO:0031805)

Other Information

Proteins

Major prion protein

Genular Protein ID: 2202173818

Symbol: PRIO_RAT

Name: Major prion protein

UniProtKB Accession Codes:

P13852 Q549H6

Database IDs:

Citations:

PubMed ID: 7909925

Title: Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in zitter rats.

PubMed ID: 7909925

DOI: 10.1016/0304-3940(94)90478-2

PubMed ID: 8879116

Title: Three-exon structure of the gene encoding the rat prion protein and its expression in tissues.

PubMed ID: 8879116

DOI: 10.1007/bf00369996

PubMed ID: 10373359

Title: Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein.

PubMed ID: 10373359

DOI: 10.1006/jmbi.1999.2831

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2889848

Title: Cloning of rat 'prion-related protein' cDNA.

PubMed ID: 2889848

Sequence Information:

Length: 254
Mass: 27804
Checksum: 28F424D13BEFA2C6
Sequence:

MANLGYWLLA LFVTTCTDVG LCKKRPKPGG WNTGGSRYPG QGSPGGNRYP PQSGGTWGQP 
HGGGWGQPHG GGWGQPHGGG WGQPHGGGWS QGGGTHNQWN KPSKPKTNLK HVAGAAAAGA 
VVGGLGGYML GSAMSRPMLH FGNDWEDRYY RENMYRYPNQ VYYRPVDQYS NQNNFVHDCV 
NITIKQHTVT TTTKGENFTE TDVKMMERVV EQMCVTQYQK ESQAYYDGRR SSAVLFSSPP 
VILLISFLIF LIVG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Prnp

Associated with

Other Information

Prion protein (PrP) is not involved in the pathogenesis of spongiform encephalopathy in zitter rats. PubMed ID: 7909925

Three-exon structure of the gene encoding the rat prion protein and its expression in tissues. PubMed ID: 8879116

Analysis of 27 mammalian and 9 avian PrPs reveals high conservation of flexible regions of the prion protein. PubMed ID: 10373359