Genular: Defining Cellular Identity and Function

Details for: Ptpn1

Gene ID: 24697

Symbol: Ptpn1

Ensembl ID: ENSRNOG00000010574

Description: protein tyrosine phosphatase, non-receptor type 1

Associated with

Cytokine signaling in immune system
(R-RNO-1280215)
Growth hormone receptor signaling
(R-RNO-982772)
Hemostasis
(R-RNO-109582)
Immune system
(R-RNO-168256)
Integrin signaling
(R-RNO-354192)
Interferon alpha/beta signaling
(R-RNO-909733)
Interferon signaling
(R-RNO-913531)
Negative regulation of met activity
(R-RNO-6807004)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet aggregation (plug formation)
(R-RNO-76009)
Ptk6 down-regulation
(R-RNO-8849472)
Regulation of ifna/ifnb signaling
(R-RNO-912694)
Signaling by insulin receptor
(R-RNO-74752)
Signaling by met
(R-RNO-6806834)
Signaling by non-receptor tyrosine kinases
(R-RNO-9006927)
Signaling by ptk6
(R-RNO-8848021)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Actin cytoskeleton organization
(GO:0030036)
Cytoplasm
(GO:0005737)
Cytoplasmic side of endoplasmic reticulum membrane
(GO:0098554)
Dephosphorylation
(GO:0016311)
Early endosome
(GO:0005769)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum unfolded protein response
(GO:0030968)
Endosome lumen
(GO:0031904)
Enzyme binding
(GO:0019899)
Ephrin receptor binding
(GO:0046875)
Insulin receptor binding
(GO:0005158)
Insulin receptor recycling
(GO:0038020)
Insulin receptor signaling pathway
(GO:0008286)
Ire1-mediated unfolded protein response
(GO:0036498)
Membrane
(GO:0016020)
Mitochondrial crista
(GO:0030061)
Mitochondrial matrix
(GO:0005759)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of perk-mediated unfolded protein response
(GO:1903898)
Negative regulation of vascular endothelial growth factor receptor signaling pathway
(GO:0030948)
Non-membrane spanning protein tyrosine phosphatase activity
(GO:0004726)
Peptidyl-tyrosine dephosphorylation
(GO:0035335)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor-beta signaling pathway
(GO:0035791)
Positive regulation of receptor catabolic process
(GO:2000646)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase 2a binding
(GO:0051721)
Protein tyrosine phosphatase activity
(GO:0004725)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of endocytosis
(GO:0030100)
Regulation of hepatocyte growth factor receptor signaling pathway
(GO:1902202)
Regulation of insulin receptor signaling pathway
(GO:0046626)
Regulation of intracellular protein transport
(GO:0033157)
Regulation of signal transduction
(GO:0009966)
Response to endoplasmic reticulum stress
(GO:0034976)
Sorting endosome
(GO:0097443)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Tyrosine-protein phosphatase non-receptor type 1

Genular Protein ID: 4267193382

Symbol: PTN1_RAT

Name: Tyrosine-protein phosphatase non-receptor type 1

UniProtKB Accession Codes:

P20417

Database IDs:

Citations:

PubMed ID: 2154749

Title: Cloning and expression of a protein-tyrosine-phosphatase.

PubMed ID: 2154749

DOI: 10.1073/pnas.87.4.1501

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1599438

Title: Insulin receptor and epidermal growth factor receptor dephosphorylation by three major rat liver protein-tyrosine phosphatases expressed in a recombinant bacterial system.

PubMed ID: 1599438

DOI: 10.1042/bj2840569

Sequence Information:

Length: 432
Mass: 49674
Checksum: 0D5859A09B1885C1
Sequence:

MEMEKEFEQI DKAGNWAAIY QDIRHEASDF PCRIAKLPKN KNRNRYRDVS PFDHSRIKLH 
QEDNDYINAS LIKMEEAQRS YILTQGPLPN TCGHFWEMVW EQKSRGVVML NRIMEKGSLK 
CAQYWPQKEE KEMVFDDTNL KLTLISEDVK SYYTVRQLEL ENLATQEARE ILHFHYTTWP 
DFGVPESPAS FLNFLFKVRE SGSLSPEHGP IVVHCSAGIG RSGTFCLADT CLLLMDKRKD 
PSSVDIKKVL LEMRRFRMGL IQTADQLRFS YLAVIEGAKF IMGDSSVQDQ WKELSHEDLE 
PPPEHVPPPP RPPKRTLEPH NGKCKELFSN HQWVSEESCE DEDILAREES RAPSIAVHSM 
SSMSQDTEVR KRMVGGGLQS AQASVPTEEE LSPTEEEQKA HRPVHWKPFL VNVCMATALA 
TGAYLCYRVC FH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.