ALOX15B | ENSG00000179593 | NCBI 247

Details for: ALOX15B

Gene ID: 247

Symbol: ALOX15B

Ensembl ID: ENSG00000179593

Description: arachidonate 15-lipoxygenase type B

Associated with

Arachidonic acid metabolism
(R-HSA-2142753)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Synthesis of 15-eicosatetraenoic acid derivatives
(R-HSA-2142770)
Adherens junction
(GO:0005912)
Apoptotic process
(GO:0006915)
Arachidonate 8(s)-lipoxygenase activity
(GO:0036403)
Arachidonate 15-lipoxygenase activity
(GO:0050473)
Arachidonic acid metabolic process
(GO:0019369)
Calcium ion binding
(GO:0005509)
Cannabinoid biosynthetic process
(GO:1901696)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endocannabinoid signaling pathway
(GO:0071926)
Extracellular exosome
(GO:0070062)
Focal adhesion
(GO:0005925)
Hepoxilin biosynthetic process
(GO:0051122)
Iron ion binding
(GO:0005506)
Linoleate 9s-lipoxygenase activity
(GO:1990136)
Linoleate 13s-lipoxygenase activity
(GO:0016165)
Linoleic acid metabolic process
(GO:0043651)
Lipid binding
(GO:0008289)
Lipid metabolic process
(GO:0006629)
Lipid oxidation
(GO:0034440)
Lipoxin a4 biosynthetic process
(GO:2001303)
Lipoxygenase pathway
(GO:0019372)
Membrane
(GO:0016020)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of growth
(GO:0045926)
Nucleus
(GO:0005634)
Phospholipid metabolic process
(GO:0006644)
Plasma membrane
(GO:0005886)
Positive regulation of chemokine production
(GO:0032722)
Positive regulation of keratinocyte differentiation
(GO:0045618)
Positive regulation of macrophage derived foam cell differentiation
(GO:0010744)
Positive regulation of peroxisome proliferator activated receptor signaling pathway
(GO:0035360)
Prostate gland development
(GO:0030850)
Protein binding
(GO:0005515)
Regulation of epithelial cell differentiation
(GO:0030856)

Other Information

Proteins

Arachidonate 15-lipoxygenase B

Genular Protein ID: 2437987847

Symbol: LX15B_HUMAN

Name: Arachidonate 15-lipoxygenase B

UniProtKB Accession Codes:

O15296 D3DTR2 Q8IYQ2 Q8TEV3 Q8TEV4 Q8TEV5 Q8TEV6 Q9UKM4

Database IDs:

Citations:

PubMed ID: 9177185

Title: Discovery of a second 15S-lipoxygenase in humans.

PubMed ID: 9177185

DOI: 10.1073/pnas.94.12.6148

PubMed ID: 11350124

Title: A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.

PubMed ID: 11350124

DOI: 10.1006/geno.2001.6519

PubMed ID: 11839751

Title: Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells.

PubMed ID: 11839751

DOI: 10.1074/jbc.m111936200

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10542053

Title: Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase.

PubMed ID: 10542053

DOI: 10.1046/j.1432-1327.1999.00818.x

PubMed ID: 10625675

Title: Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2.

PubMed ID: 10625675

DOI: 10.1074/jbc.275.2.1287

PubMed ID: 11956198

Title: 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.

PubMed ID: 11956198

DOI: 10.1074/jbc.m201084200

PubMed ID: 12704195

Title: Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants.

PubMed ID: 12704195

DOI: 10.1074/jbc.m301920200

PubMed ID: 16112079

Title: Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist.

PubMed ID: 16112079

DOI: 10.1016/j.bbrc.2005.08.029

PubMed ID: 17493578

Title: Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.

PubMed ID: 17493578

DOI: 10.1016/j.abb.2007.04.007

PubMed ID: 18067895

Title: 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.

PubMed ID: 18067895

DOI: 10.1016/j.atherosclerosis.2007.10.027

PubMed ID: 18311922

Title: Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.

PubMed ID: 18311922

DOI: 10.1021/bi702530z

PubMed ID: 18755188

Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.

PubMed ID: 18755188

DOI: 10.1016/j.febslet.2008.08.017

PubMed ID: 22912809

Title: Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.

PubMed ID: 22912809

DOI: 10.1371/journal.pone.0043142

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 27145229

Title: Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential.

PubMed ID: 27145229

DOI: 10.1021/acs.biochem.5b01339

PubMed ID: 27435673

Title: Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS.

PubMed ID: 27435673

DOI: 10.1074/jbc.m116.741454

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 24497644

Title: The structure of human 15-lipoxygenase-2 with a substrate mimic.

PubMed ID: 24497644

DOI: 10.1074/jbc.m113.543777

Sequence Information:

Length: 676
Mass: 75857
Checksum: 4F641DF2F9D492C6
Sequence:

MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED 
VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE 
GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK 
NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS 
QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT 
NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV 
RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL 
IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI 
WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ 
YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT 
CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNQGLVL 
PYTYLDPPLI ENSVSI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ALOX15B

Associated with

Other Information

Discovery of a second 15S-lipoxygenase in humans. PubMed ID: 9177185

A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression. PubMed ID: 11350124

Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. PubMed ID: 11839751

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase. PubMed ID: 10542053

Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2. PubMed ID: 10625675

15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist. PubMed ID: 11956198

Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants. PubMed ID: 12704195

Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist. PubMed ID: 16112079

Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases. PubMed ID: 17493578

15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration. PubMed ID: 18067895

Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine. PubMed ID: 18311922

Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes. PubMed ID: 18755188

Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis. PubMed ID: 22912809

Functional characterization of genetic enzyme variations in human lipoxygenases. PubMed ID: 24282679

Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential. PubMed ID: 27145229

Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS. PubMed ID: 27435673

15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5. PubMed ID: 32404334

The structure of human 15-lipoxygenase-2 with a substrate mimic. PubMed ID: 24497644