Details for: ALOX15B

Gene ID: 247

Symbol: ALOX15B

Ensembl ID: ENSG00000179593

Description: arachidonate 15-lipoxygenase type B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.71
    Marker Score: 11115
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1168
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.45
    Marker Score: 1213
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.38
    Marker Score: 10787
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.3
    Marker Score: 2092
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.16
    Marker Score: 2349
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48048
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 507
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 460
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.97
    Marker Score: 15536
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 393.5
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.95
    Marker Score: 550.5
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5289
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 624
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1389
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.67
    Marker Score: 301
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.66
    Marker Score: 5653
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.64
    Marker Score: 195
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.59
    Marker Score: 266
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.59
    Marker Score: 376
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.58
    Marker Score: 638
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.57
    Marker Score: 1619
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.57
    Marker Score: 596
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.55
    Marker Score: 2913
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.53
    Marker Score: 273
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7190
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.43
    Marker Score: 156
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.42
    Marker Score: 130
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.41
    Marker Score: 396.5
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.38
    Marker Score: 100
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.37
    Marker Score: 682
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.36
    Marker Score: 562
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.36
    Marker Score: 219
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.36
    Marker Score: 436.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.36
    Marker Score: 571
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.33
    Marker Score: 220
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.33
    Marker Score: 105
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.32
    Marker Score: 2410
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.31
    Marker Score: 274
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.31
    Marker Score: 346
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.29
    Marker Score: 199
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.29
    Marker Score: 3917
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.29
    Marker Score: 1736
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.28
    Marker Score: 506
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.27
    Marker Score: 830
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.26
    Marker Score: 134
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 120
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.25
    Marker Score: 317
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.24
    Marker Score: 491.5
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.24
    Marker Score: 263
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 139
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.23
    Marker Score: 153
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.22
    Marker Score: 915
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.21
    Marker Score: 79
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.21
    Marker Score: 811
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.2
    Marker Score: 496
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.2
    Marker Score: 318
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.2
    Marker Score: 230
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.19
    Marker Score: 333
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.18
    Marker Score: 114
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.18
    Marker Score: 128
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.17
    Marker Score: 116
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.17
    Marker Score: 218
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.17
    Marker Score: 184
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.16
    Marker Score: 67
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.16
    Marker Score: 143
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.15
    Marker Score: 105
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.15
    Marker Score: 8614
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.15
    Marker Score: 396
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.15
    Marker Score: 67
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 47
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.15
    Marker Score: 85
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.15
    Marker Score: 148
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.14
    Marker Score: 708.5
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.14
    Marker Score: 163
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.14
    Marker Score: 26.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 71
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.13
    Marker Score: 125
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.13
    Marker Score: 27
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.13
    Marker Score: 3203
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.12
    Marker Score: 27

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Other Information

**Key characteristics:** - The protein is a transmembrane protein with a molecular weight of approximately 150 kDa. - It belongs to the ALOX family of enzymes, which are involved in the metabolism of arachidonic acid and its derivatives. - It is a key regulator of cell population proliferation and survival. **Pathways and functions:** - The protein is involved in the apoptotic process, as it is expressed in cells that are undergoing apoptosis. - It also plays a role in the arachidonate 8(s)-lipoxygenase activity, as it is involved in the production of arachidonic acid, which is a precursor for the synthesis of eicosanoids. - It also participates in the regulation of calcium ion binding and fatty acid metabolism. **Clinical significance:** - Mutations in the ALOX15B gene have been linked to several human diseases, including atherosclerosis, cancer, and neurodegenerative disorders. - Studies of the role of ALOX15B in these diseases are ongoing, and it is a potential therapeutic target for these conditions. **Additional information:** - The gene is located on chromosome 15q21.1. - It is a pseudogene, meaning that it is not expressed in the absence of a functional copy of the gene. - It is a member of the ALOX family, which is a large and diverse group of enzymes involved in the metabolism of arachidonic acid and its derivatives.

Genular Protein ID: 2437987847

Symbol: LX15B_HUMAN

Name: Arachidonate 15-lipoxygenase B

UniProtKB Accession Codes:

O15296 D3DTR2 Q8IYQ2 Q8TEV3 Q8TEV4 Q8TEV5 Q8TEV6 Q9UKM4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 76 ChEMBL 1 ChiTaRS 1 DNASU 1 DisGeNET 1 DrugCentral 1 EC 1 EMBL 15 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 36 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PRINTS 2 PRO 1 PROSITE 4 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 3 Rhea 42 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 3 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9177185

Title: Discovery of a second 15S-lipoxygenase in humans.

PubMed ID: 9177185

DOI: 10.1073/pnas.94.12.6148

PubMed ID: 11350124

Title: A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.

PubMed ID: 11350124

DOI: 10.1006/geno.2001.6519

PubMed ID: 11839751

Title: Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells.

PubMed ID: 11839751

DOI: 10.1074/jbc.m111936200

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10542053

Title: Differential characteristics of human 15-lipoxygenase isozymes and a novel splice variant of 15S-lipoxygenase.

PubMed ID: 10542053

DOI: 10.1046/j.1432-1327.1999.00818.x

PubMed ID: 10625675

Title: Identification of amino acid determinants of the positional specificity of mouse 8S-lipoxygenase and human 15S-lipoxygenase-2.

PubMed ID: 10625675

DOI: 10.1074/jbc.275.2.1287

PubMed ID: 11956198

Title: 15-Lipoxygenase metabolism of 2-arachidonylglycerol. Generation of a peroxisome proliferator-activated receptor alpha agonist.

PubMed ID: 11956198

DOI: 10.1074/jbc.m201084200

PubMed ID: 12704195

Title: Subcellular localization and tumor-suppressive functions of 15-lipoxygenase 2 (15-LOX2) and its splice variants.

PubMed ID: 12704195

DOI: 10.1074/jbc.m301920200

PubMed ID: 16112079

Title: Double dioxygenation by mouse 8S-lipoxygenase: specific formation of a potent peroxisome proliferator-activated receptor alpha agonist.

PubMed ID: 16112079

DOI: 10.1016/j.bbrc.2005.08.029

PubMed ID: 17493578

Title: Oxidative metabolism of lipoamino acids and vanilloids by lipoxygenases and cyclooxygenases.

PubMed ID: 17493578

DOI: 10.1016/j.abb.2007.04.007

PubMed ID: 18067895

Title: 15-Lipoxygenase-2 expression in human macrophages induces chemokine secretion and T cell migration.

PubMed ID: 18067895

DOI: 10.1016/j.atherosclerosis.2007.10.027

PubMed ID: 18311922

Title: Oxidative metabolism of a fatty acid amide hydrolase-regulated lipid, arachidonoyltaurine.

PubMed ID: 18311922

DOI: 10.1021/bi702530z

PubMed ID: 18755188

Title: Reciprocal regulation of 12- and 15-lipoxygenases by UV-irradiation in human keratinocytes.

PubMed ID: 18755188

DOI: 10.1016/j.febslet.2008.08.017

PubMed ID: 22912809

Title: Arachidonate 15-lipoxygenase type B knockdown leads to reduced lipid accumulation and inflammation in atherosclerosis.

PubMed ID: 22912809

DOI: 10.1371/journal.pone.0043142

PubMed ID: 24282679

Title: Functional characterization of genetic enzyme variations in human lipoxygenases.

PubMed ID: 24282679

DOI: 10.1016/j.redox.2013.11.001

PubMed ID: 27145229

Title: Strict Regiospecificity of Human Epithelial 15-Lipoxygenase-2 Delineates Its Transcellular Synthesis Potential.

PubMed ID: 27145229

DOI: 10.1021/acs.biochem.5b01339

PubMed ID: 27435673

Title: Membrane-dependent Activities of Human 15-LOX-2 and Its Murine Counterpart: IMPLICATIONS FOR MURINE MODELS OF ATHEROSCLEROSIS.

PubMed ID: 27435673

DOI: 10.1074/jbc.m116.741454

PubMed ID: 32404334

Title: 15-Lipoxygenase-1 biosynthesis of 7S,14S-diHDHA implicates 15-lipoxygenase-2 in biosynthesis of resolvin D5.

PubMed ID: 32404334

DOI: 10.1194/jlr.ra120000777

PubMed ID: 24497644

Title: The structure of human 15-lipoxygenase-2 with a substrate mimic.

PubMed ID: 24497644

DOI: 10.1074/jbc.m113.543777

Sequence Information:

  • Length: 676
  • Mass: 75857
  • Checksum: 4F641DF2F9D492C6
  • Sequence:
    • MAEFRVRVST GEAFGAGTWD KVSVSIVGTR GESPPLPLDN LGKEFTAGAE EDFQVTLPED 
VGRVLLLRVH KAPPVLPLLG PLAPDAWFCR WFQLTPPRGG HLLFPCYQWL EGAGTLVLQE 
GTAKVSWADH HPVLQQQRQE ELQARQEMYQ WKAYNPGWPH CLDEKTVEDL ELNIKYSTAK 
NANFYLQAGS AFAEMKIKGL LDRKGLWRSL NEMKRIFNFR RTPAAEHAFE HWQEDAFFAS 
QFLNGLNPVL IRRCHYLPKN FPVTDAMVAS VLGPGTSLQA ELEKGSLFLV DHGILSGIQT 
NVINGKPQFS AAPMTLLYQS PGCGPLLPLA IQLSQTPGPN SPIFLPTDDK WDWLLAKTWV 
RNAEFSFHEA LTHLLHSHLL PEVFTLATLR QLPHCHPLFK LLIPHTRYTL HINTLARELL 
IVPGQVVDRS TGIGIEGFSE LIQRNMKQLN YSLLCLPEDI RTRGVEDIPG YYYRDDGMQI 
WGAVERFVSE IIGIYYPSDE SVQDDRELQA WVREIFSKGF LNQESSGIPS SLETREALVQ 
YVTMVIFTCS AKHAAVSAGQ FDSCAWMPNL PPSMQLPPPT SKGLATCEGF IATLPPVNAT 
CDVILALWLL SKEPGDQRPL GTYPDEHFTE EAPRRSIATF QSRLAQISRG IQERNQGLVL 
PYTYLDPPLI ENSVSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.