Genular: Defining Cellular Identity and Function

Details for: Raf1

Gene ID: 24703

Symbol: Raf1

Ensembl ID: ENSRNOG00000010153

Description: Raf-1 proto-oncogene, serine/threonine kinase

Associated with

Adaptive immune system
(R-RNO-1280218)
C-type lectin receptors (clrs)
(R-RNO-5621481)
Cd209 (dc-sign) signaling
(R-RNO-5621575)
Cytokine signaling in immune system
(R-RNO-1280215)
Gp1b-ix-v activation signalling
(R-RNO-430116)
Hemostasis
(R-RNO-109582)
Ifng signaling activates mapks
(R-RNO-9732724)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Interferon gamma signaling
(R-RNO-877300)
Interferon signaling
(R-RNO-913531)
Ion channel transport
(R-RNO-983712)
Map2k and mapk activation
(R-RNO-5674135)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Negative feedback regulation of mapk pathway
(R-RNO-5674499)
Negative regulation of mapk pathway
(R-RNO-5675221)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Raf/map kinase cascade
(R-RNO-5673001)
Raf activation
(R-RNO-5673000)
Rap1 signalling
(R-RNO-392517)
Stimuli-sensing channels
(R-RNO-2672351)
Transport of small molecules
(R-RNO-382551)
Adenylate cyclase activator activity
(GO:0010856)
Adenylate cyclase binding
(GO:0008179)
Atp binding
(GO:0005524)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Death-inducing signaling complex assembly
(GO:0071550)
Enzyme binding
(GO:0019899)
Erbb2-erbb3 signaling pathway
(GO:0038133)
Extrinsic apoptotic signaling pathway via death domain receptors
(GO:0008625)
Face development
(GO:0060324)
Golgi apparatus
(GO:0005794)
Heart development
(GO:0007507)
Identical protein binding
(GO:0042802)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Insulin receptor signaling pathway
(GO:0008286)
Insulin secretion involved in cellular response to glucose stimulus
(GO:0035773)
Intermediate filament cytoskeleton organization
(GO:0045104)
Intracellular glucose homeostasis
(GO:0001678)
Intracellular signal transduction
(GO:0035556)
Mapk cascade
(GO:0000165)
Map kinase kinase kinase activity
(GO:0004709)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Mitogen-activated protein kinase kinase binding
(GO:0031434)
Myelination
(GO:0042552)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Neurotrophin trk receptor signaling pathway
(GO:0048011)
Nucleus
(GO:0005634)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of peptidyl-serine phosphorylation
(GO:0033138)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Pseudopodium
(GO:0031143)
Response to hypoxia
(GO:0001666)
Response to muscle stretch
(GO:0035994)
Schwann cell development
(GO:0014044)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Somatic stem cell population maintenance
(GO:0035019)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Type b pancreatic cell proliferation
(GO:0044342)

Other Information

Proteins

RAF proto-oncogene serine/threonine-protein kinase
A0A8I5ZWZ7_RAT

Genular Protein ID: 3673217893

Symbol: RAF1_RAT

Name: RAF proto-oncogene serine/threonine-protein kinase

UniProtKB Accession Codes:

P11345

Database IDs:

Citations:

PubMed ID: 3550433

Title: Rat c-raf oncogene activation by a rearrangement that produces a fused protein.

PubMed ID: 3550433

DOI: 10.1128/mcb.7.3.1226-1232.1987

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19381846

Title: Raf-1: a novel cardiac troponin T kinase.

PubMed ID: 19381846

DOI: 10.1007/s10974-009-9176-y

PubMed ID: 19319189

Title: Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector.

PubMed ID: 19319189

DOI: 10.1371/journal.pone.0004884

PubMed ID: 19878719

Title: RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways.

PubMed ID: 19878719

DOI: 10.1016/j.cellsig.2009.10.005

PubMed ID: 7565670

Title: A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function.

PubMed ID: 7565670

DOI: 10.1128/mcb.15.10.5214

PubMed ID: 21917714

Title: Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF.

PubMed ID: 21917714

DOI: 10.1126/scisignal.2001936

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 9931261

Title: Nuclear magnetic resonance and molecular dynamics studies on the interactions of the Ras-binding domain of Raf-1 with wild-type and mutant Ras proteins.

PubMed ID: 9931261

DOI: 10.1006/jmbi.1998.2472

Sequence Information:

Length: 648
Mass: 72928
Checksum: E9AFB5975064193E
Sequence:

MEHIQGAWKT ISNGFGLKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD SSKTSNTIRV 
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLQEHKGKKA RLDWNTDAAS 
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 
PTMCVDWSNI RQLLLFPNST ASDSGVPAPP SFTMRRMRES VSRMPASSQH RYSTPHAFTF 
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIEDA IRSHSESASP SALSSSPNNL 
SPTGWSQPKT PVPAQRERAP GSGTQEKNKI RPRGQRDSSY YWEIEASEVM LSTRIGSGSF 
GTVYKGKWHG DVAVKILKVV DPTPEQLQAF RNEVAVLRKT RHVNILLFMG YMTKDNLAIV 
TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH AKNIIHRDMK SNNIFLHEGL 
TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ DNNPFSFQSD VYSYGIVLYE 
LMTGELPYSH INNRDQIIFM VGRGYASPDL SRLYKNCPKA MKRLVADCVK KVKEERPLFP 
QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT TSPRLPVF

Genular Protein ID: 2082568994

Symbol: A0A8I5ZWZ7_RAT

Name: N/A

UniProtKB Accession Codes:

A0A8I5ZWZ7

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 668
Mass: 75189
Checksum: AEA5C32D0D9DD06E
Sequence:

MEHIQGAWKT ISNGFGLKDA VFDGSSCISP TIVQQFGYQR RASDDGKLTD SSKTSNTIRV 
FLPNKQRTVV NVRNGMSLHD CLMKALKVRG LQPECCAVFR LLQEHKGKKA RLDWNTDAAS 
LIGEELQVDF LDHVPLTTHN FARKTFLKLA FCDICQKFLL NGFRCQTCGY KFHEHCSTKV 
PTMCVDWSNI RQLLLFPNST ASDSGVPAPP SFTMRRMRES VSRMPASSQH RYSTPHAFTF 
NTSSPSSEGS LSQRQRSTST PNVHMVSTTL PVDSRMIENN SLNASPRACS RRFCLRGRDA 
IRSHSESASP SALSSSPNNL SPTGWSQPKT PVPAQRERAP GSGTQEKNKI RPRGQRDSSY 
YWEIEASEVM LSTRIGSGSF GTVYKGKWHG DVAVKILKVV DPTPEQLQAF RNEVAVLRKT 
RHVNILLFMG YMTKDNLAIV TQWCEGSSLY KHLHVQETKF QMFQLIDIAR QTAQGMDYLH 
AKNIIHRDMK SNNIFLHEGL TVKIGDFGLA TVKSRWSGSQ QVEQPTGSVL WMAPEVIRMQ 
DNNPFSFQSD VYSYGIVLYE LMTGELPYSH INNRDQIIFM VGRGYASPDL SRLYKNCPKA 
MKRLVADCVK KVKEERPLFP QILSSIELLQ HSLPKINRSA SEPSLHRAAH TEDINACTLT 
TSPRLPVF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Raf1

Associated with

Other Information

Rat c-raf oncogene activation by a rearrangement that produces a fused protein. PubMed ID: 3550433

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Raf-1: a novel cardiac troponin T kinase. PubMed ID: 19381846

Regulator of G-protein signaling 14 (RGS14) is a selective H-Ras effector. PubMed ID: 19319189

RGS14 is a multifunctional scaffold that integrates G protein and Ras/Raf MAPkinase signalling pathways. PubMed ID: 19878719

A proline-rich sequence unique to MEK1 and MEK2 is required for raf binding and regulates MEK function. PubMed ID: 7565670

Protein arginine methyltransferase 5 regulates ERK1/2 signal transduction amplitude and cell fate through CRAF. PubMed ID: 21917714

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Nuclear magnetic resonance and molecular dynamics studies on the interactions of the Ras-binding domain of Raf-1 with wild-type and mutant Ras proteins. PubMed ID: 9931261

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822