Genular: Defining Cellular Identity and Function

Details for: Rb1

Gene ID: 24708

Symbol: Rb1

Ensembl ID: ENSRNOG00000016029

Description: RB transcriptional corepressor 1

Associated with

Apc/c-mediated degradation of cell cycle proteins
(R-RNO-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-RNO-174178)
Cell cycle
(R-RNO-1640170)
Cell cycle, mitotic
(R-RNO-69278)
Condensation of prophase chromosomes
(R-RNO-2299718)
Cyclin a:cdk2-associated events at s phase entry
(R-RNO-69656)
Cyclin d associated events in g1
(R-RNO-69231)
Cyclin e associated events during g1/s transition
(R-RNO-69202)
E2f mediated regulation of dna replication
(R-RNO-113510)
G1 phase
(R-RNO-69236)
G1/s transition
(R-RNO-69206)
Inhibition of replication initiation of damaged dna by rb1/e2f1
(R-RNO-113501)
Mitotic g1 phase and g1/s transition
(R-RNO-453279)
Mitotic prophase
(R-RNO-68875)
M phase
(R-RNO-68886)
Phosphorylation of proteins involved in g1/s transition by active cyclin e:cdk2 complexes
(R-RNO-69200)
S phase
(R-RNO-69242)
Aortic valve morphogenesis
(GO:0003180)
Apoptotic process
(GO:0006915)
Cell differentiation
(GO:0030154)
Cell division
(GO:0051301)
Cell morphogenesis involved in neuron differentiation
(GO:0048667)
Cell population proliferation
(GO:0008283)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to xenobiotic stimulus
(GO:0071466)
Chondrocyte differentiation
(GO:0002062)
Chromatin
(GO:0000785)
Chromatin lock complex
(GO:0061793)
Chromosome organization
(GO:0051276)
Cyclin/cdk positive transcription elongation factor complex
(GO:0008024)
Digestive tract development
(GO:0048565)
Disordered domain specific binding
(GO:0097718)
Dna-binding transcription factor binding
(GO:0140297)
Enucleate erythrocyte differentiation
(GO:0043353)
Enzyme binding
(GO:0019899)
Epithelial cell proliferation
(GO:0050673)
G1/s transition of mitotic cell cycle
(GO:0000082)
Glial cell apoptotic process
(GO:0034349)
Glial cell proliferation
(GO:0014009)
Hepatocyte apoptotic process
(GO:0097284)
Heterochromatin formation
(GO:0031507)
Identical protein binding
(GO:0042802)
Importin-alpha family protein binding
(GO:0061676)
Kinase binding
(GO:0019900)
Maintenance of mitotic sister chromatid cohesion
(GO:0034088)
Molecular adaptor activity
(GO:0060090)
Myoblast differentiation
(GO:0045445)
Negative regulation of apoptotic signaling pathway
(GO:2001234)
Negative regulation of cell cycle
(GO:0045786)
Negative regulation of cell growth
(GO:0030308)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of g1/s transition of mitotic cell cycle
(GO:2000134)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of hepatocyte apoptotic process
(GO:1903944)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of myofibroblast differentiation
(GO:1904761)
Negative regulation of smoothened signaling pathway
(GO:0045879)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron apoptotic process
(GO:0051402)
Neuron differentiation
(GO:0030182)
Neuron maturation
(GO:0042551)
Neuron projection development
(GO:0031175)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphoprotein binding
(GO:0051219)
Pml body
(GO:0016605)
Positive regulation of collagen fibril organization
(GO:1904028)
Positive regulation of extracellular matrix organization
(GO:1903055)
Positive regulation of macrophage differentiation
(GO:0045651)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein localization to chromosome, centromeric region
(GO:0071459)
Ras protein signal transduction
(GO:0007265)
Rb-e2f complex
(GO:0035189)
Regulation of cell cycle
(GO:0051726)
Regulation of cell growth
(GO:0001558)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of g1/s transition of mitotic cell cycle
(GO:2000045)
Regulation of mitotic cell cycle
(GO:0007346)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sister chromatid biorientation
(GO:0031134)
Skeletal muscle cell differentiation
(GO:0035914)
Smoothened signaling pathway
(GO:0007224)
Spermatogenesis
(GO:0007283)
Spindle
(GO:0005819)
Striated muscle cell differentiation
(GO:0051146)
Tissue homeostasis
(GO:0001894)
Transcription by rna polymerase ii
(GO:0006366)
Transcription regulator complex
(GO:0005667)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Retinoblastoma-associated protein

Genular Protein ID: 2533584287

Symbol: RB_RAT

Name: Retinoblastoma-associated protein

UniProtKB Accession Codes:

P33568 Q63527

Database IDs:

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 7665085

Title: Isolation and sequence polymorphism of a rat retinoblastoma (RB) cDNA.

PubMed ID: 7665085

DOI: 10.1016/0378-1119(95)00154-x

PubMed ID: 8441612

Title: Cloning and sequence of the rat retinoblastoma (Rb) gene cDNA.

PubMed ID: 8441612

DOI: 10.1093/nar/21.1.170

PubMed ID: 9697699

Title: A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability.

PubMed ID: 9697699

DOI: 10.1038/1258

PubMed ID: 10542199

Title: Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells.

PubMed ID: 10542199

DOI: 10.1074/jbc.274.45.31775

PubMed ID: 10888886

Title: DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters.

PubMed ID: 10888886

DOI: 10.1038/77124

PubMed ID: 19081374

Title: A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression.

PubMed ID: 19081374

DOI: 10.1016/j.neuron.2008.09.040

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 920
Mass: 105025
Checksum: 3BA735EA59927301
Sequence:

MPPKAPRRTA AAEPPPPPPP PPEDDPAQDS DPEELPLIRL EFEKIEEPEF IALCQKLKVP 
DHVRERAWLT WEKVSSVDGI LEGYIQKKKE LWGICIFIAA VDLDEMPFTF TELQKSIETS 
VYKFFDLLKE IDTSTKVDNA VSRLLKKYNV LCALYSKLER TCGLIYLTQP SSGLSTEINS 
MLVLKVSWIT FLLAKGEVVQ MEDDLVISFQ LMLCVLDYFI KLSPPALLRE PYKTAATPIN 
GSPRTPRRGQ NRSARIAKQL ESDTRTIEVL CKEHECNVDE VKNVYFKNFI PFISSLGIVS 
SNGLPELESL SKRYEEVYLK SKDLDARLFL DHDKTLQTDT IDSFETERTP RKSNPDEEAN 
MVTPHTPVRT VMNTIQQLMV ILNSASDQPS ENLISYFSNC TVNPKENILK RVKDVGHIFK 
EKFASAVGQG CIDIGAQRYK LGVRLYYRVM ESMLKSEEER LSIQNFSKLL NDNIFHMSLL 
ACALEVVMAT YSRSMLQNLD SGTDLSFPWI LNVLNLKAFD FYKVIESFIK VEANLTREMI 
KHLERCEHRI MESLAWLSDS PLFDLIKQSK DGEGPDHLES ACSLSLPLQS NHTAADMYLS 
PIRSPKKRTS TTRVNSAANT ETQAASAFHT QKPLKSTSLS LFYKKVYRLA YLRLNTLCAR 
LLSDHPELEH IIWTLFQHTL ENEYELMKDR HLDQIMMCSM YGICKVKNID LKFKIIVTAY 
KDLPHAAQET FKRVLIREEE FDSIIVFYNS VFMQRLKTNI LQYASTRPPT LSPIPHIPRS 
PYKFSSSPLR IPGGNIYISP LKSPYKISEG LPTPTKMTPR SRILVSIGES FGTSEKFQKI 
NQMVCNSDRV LKRSAEGGNP PKPLKKLRFD IEGSDEADGS KHLPAESKFQ QKLAEMTSTR 
TRMQKQKLND SMEISNKEEK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rb1

Associated with

Other Information

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Isolation and sequence polymorphism of a rat retinoblastoma (RB) cDNA. PubMed ID: 7665085

Cloning and sequence of the rat retinoblastoma (Rb) gene cDNA. PubMed ID: 8441612

A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. PubMed ID: 9697699

Cdc2 and Cdk2 kinase activated by transforming growth factor-beta1 trigger apoptosis through the phosphorylation of retinoblastoma protein in FaO hepatoma cells. PubMed ID: 10542199

DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. PubMed ID: 10888886

A calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. PubMed ID: 19081374

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903