Details for: Scn2a
Associated with
Other Information
Genular Protein ID: 3424892408
Symbol: SCN2A_RAT
Name: Sodium channel protein brain II subunit alpha
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 3754035
Title: Existence of distinct sodium channel messenger RNAs in rat brain.
PubMed ID: 3754035
DOI: 10.1038/320188a0
PubMed ID: 1658937
Title: A phosphorylation site in the Na+ channel required for modulation by protein kinase C.
PubMed ID: 1658937
PubMed ID: 1322892
Title: Phosphorylation of purified rat brain Na+ channel reconstituted into phospholipid vesicles by protein kinase C.
PubMed ID: 1322892
PubMed ID: 10827969
Title: Neuronal death and perinatal lethality in voltage-gated sodium channel alpha(II)-deficient mice.
PubMed ID: 10827969
PubMed ID: 11166117
Title: A gain-of-function mutation in the sodium channel gene Scn2a results in seizures and behavioral abnormalities.
PubMed ID: 11166117
PubMed ID: 15548568
Title: Molecular determinants of voltage-gated sodium channel regulation by the Nedd4/Nedd4-like proteins.
PubMed ID: 15548568
PubMed ID: 16641100
Title: Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.
PubMed ID: 16641100
PubMed ID: 20678086
Title: Molecular determination of selectivity of the site 3 modulator (BmK I) to sodium channels in the CNS: a clue to the importance of Nav1.6 in BmK I-induced neuronal hyperexcitability.
PubMed ID: 20678086
DOI: 10.1042/bj20100517
PubMed ID: 20131913
Title: Multisite phosphorylation of voltage-gated sodium channel alpha subunits from rat brain.
PubMed ID: 20131913
DOI: 10.1021/pr901171q
PubMed ID: 22673903
Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.
PubMed ID: 22673903
DOI: 10.1038/ncomms1871
PubMed ID: 24297919
Title: Crystallographic insights into sodium-channel modulation by the beta4 subunit.
PubMed ID: 24297919
PubMed ID: 24497506
Title: A disulfide tether stabilizes the block of sodium channels by the conotoxin muO[section sign]-GVIIJ.
PubMed ID: 24497506
PubMed ID: 26039939
Title: Probing the redox states of sodium channel cysteines at the binding site of muO[section sign]-conotoxin GVIIJ.
PubMed ID: 26039939
PubMed ID: 9893979
Title: Solution structure of the sodium channel inactivation gate.
PubMed ID: 9893979
DOI: 10.1021/bi9823380
PubMed ID: 21439835
Title: Structural and energetic determinants of apo calmodulin binding to the IQ motif of the Na(V)1.2 voltage-dependent sodium channel.
PubMed ID: 21439835
PubMed ID: 26894959
Title: Binary architecture of the Nav1.2-beta2 signaling complex.
PubMed ID: 26894959
DOI: 10.7554/elife.10960
PubMed ID: 28029095
Title: SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons.
PubMed ID: 28029095
DOI: 10.7554/elife.20054
Sequence Information:
- Length: 2005
- Mass: 227874
- Checksum: 861BE583D79F8324
- Sequence:
MARSVLVPPG PDSFRFFTRE SLAAIEQRIA EEKAKRPKQE RKDEDDENGP KPNSDLEAGK SLPFIYGDIP PEMVSEPLED LDPYYINKKT FIVLNKGKAI SRFSATSALY ILTPFNPIRK LAIKILVHSL FNVLIMCTIL TNCVFMTMSN PPDWTKNVEY TFTGIYTFES LIKILARGFC LEDFTFLRNP WNWLDFTVIT FAYVTEFVNL GNVSALRTFR VLRALKTISV IPGLKTIVGA LIQSVKKLSD VMILTVFCLS VFALIGLQLF MGNLRNKCLQ WPPDNSTFEI NITSFFNNSL DWNGTAFNRT VNMFNWDEYI EDKSHFYFLE GQNDALLCGN SSDAGQCPEG YICVKAGRNP NYGYTSFDTF SWAFLSLFRL MTQDFWENLY QLTLRAAGKT YMIFFVLVIF LGSFYLINLI LAVVAMAYEE QNQATLEEAE QKEAEFQQML EQLKKQQEEA QAAAAAASAE SRDFSGAGGI GVFSESSSVA SKLSSKSEKE LKNRRKKKKQ KEQAGEEEKE DAVRKSASED SIRKKGFQFS LEGSRLTYEK RFSSPHQSLL SIRGSLFSPR RNSRASLFNF KGRVKDIGSE NDFADDEHST FEDNDSRRDS LFVPHRHGER RPSNVSQASR ASRGIPTLPM NGKMHSAVDC NGVVSLVGGP SALTSPVGQL LPEGTTTETE IRKRRSSSYH VSMDLLEDPS RQRAMSMASI LTNTMEELEE SRQKCPPCWY KFANMCLIWD CCKPWLKVKH VVNLVVMDPF VDLAITICIV LNTLFMAMEH YPMTEQFSSV LSVGNLVFTG IFTAEMFLKI IAMDPYYYFQ EGWNIFDGFI VSLSLMELGL ANVEGLSVLR SFRLLRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM QLFGKSYKEC VCKISNDCEL PRWHMHHFFH SFLIVFRVLC GEWIETMWDC MEVAGQTMCL TVFMMVMVIG NLVVLNLFLA LLLSSFSSDN LAATDDDNEM NNLQIAVGRM QKGIDFVKRK IREFIQKAFV RKQKALDEIK PLEDLNNKKD SCISNHTTIE IGKDLNYLKD GNGTTSGIGS SVEKYVVDES DYMSFINNPS LTVTVPIALG ESDFENLNTE EFSSESDMEE SKEKLNATSS SEGSTVDIGA PAEGEQPEAE PEESLEPEAC FTEDCVRKFK CCQISIEEGK GKLWWNLRKT CYKIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT MLEYADKVFT YIFILEMLLK WVAYGFQMYF TNAWCWLDFL IVDVSLVSLT ANALGYSELG AIKSLRTLRA LRPLRALSRF EGMRVVVNAL LGAIPSIMNV LLVCLIFWLI FSIMGVNLFA GKFYHCINYT TGEMFDVSVV NNYSECQALI ESNQTARWKN VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSRNVELQ PKYEDNLYMY LYFVIFIIFG SFFTLNLFIG VIIDNFNQQK KKFGGQDIFM TEEQKKYYNA MKKLGSKKPQ KPIPRPANKF QGMVFDFVTK QVFDISIMIL ICLNMVTMMV ETDDQSQEMT NILYWINLVF IVLFTGECVL KLISLRHYYF TIGWNIFDFV VVILSIVGMF LAELIEKYFV SPTLFRVIRL ARIGRILRLI KGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIYAIFGMS NFAYVKREVG IDDMFNFETF GNSMICLFQI TTSAGWDGLL APILNSGPPD CDPEKDHPGS SVKGDCGNPS VGIFFFVSYI IISFLVVVNM YIAVILENFS VATEESAEPL SEDDFEMFYE VWEKFDPDAT QFIEFCKLSD FAAALDPPLL IAKPNKVQLI AMDLPMVSGD RIHCLDILFA FTKRVLGESG EMDALRIQME ERFMASNPSK VSYEPITTTL KRKQEEVSAI VIQRAYRRYL LKQKVKKVSS IYKKDKGKED EGTPIKEDII TDKLNENSTP EKTDVTPSTT SPPSYDSVTK PEKEKFEKDK SEKEDKGKDI RESKK
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.