Genular: Defining Cellular Identity and Function

Details for: Sct

Gene ID: 24769

Symbol: Sct

Ensembl ID: ENSRNOG00000017873

Description: secretin

Associated with

Class b/2 (secretin family receptors)
(R-RNO-373080)
Glucagon-type ligand receptors
(R-RNO-420092)
Gpcr ligand binding
(R-RNO-500792)
Signaling by gpcr
(R-RNO-372790)
Brain development
(GO:0007420)
Dentate gyrus development
(GO:0021542)
Diet induced thermogenesis
(GO:0002024)
Digestive hormone activity
(GO:0046659)
Embryonic digestive tract development
(GO:0048566)
Extracellular space
(GO:0005615)
G protein-coupled receptor binding
(GO:0001664)
Hippocampus development
(GO:0021766)
Hormone activity
(GO:0005179)
Intracellular water homeostasis
(GO:0009992)
Negative regulation of gastrin-induced gastric acid secretion
(GO:1903640)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neuronal stem cell population maintenance
(GO:0097150)
Neuron apoptotic process
(GO:0051402)
Positive regulation of camp-mediated signaling
(GO:0043950)
Positive regulation of lipid catabolic process
(GO:0050996)
Positive regulation of pancreatic juice secretion
(GO:0090187)
Positive regulation of somatostatin secretion
(GO:0090274)
Regulation of appetite
(GO:0032098)
Regulation of synaptic plasticity
(GO:0048167)
Response to nutrient levels
(GO:0031667)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Visual learning
(GO:0008542)

Other Information

Proteins

SECR_RAT

Genular Protein ID: 3883400986

Symbol: SECR_RAT

Name: N/A

UniProtKB Accession Codes:

P11384

Database IDs:

Citations:

PubMed ID: 2315322

Title: Secretin: structure of the precursor and tissue distribution of the mRNA.

PubMed ID: 2315322

DOI: 10.1073/pnas.87.6.2299

PubMed ID: 1711228

Title: The secretin gene: evolutionary history, alternative splicing, and developmental regulation.

PubMed ID: 1711228

DOI: 10.1073/pnas.88.12.5335

PubMed ID: 2061329

Title: The secretin precursor gene. Structure of the coding region and expression in the brain.

PubMed ID: 2061329

DOI: 10.1016/s0021-9258(18)98940-4

PubMed ID: 2719704

Title: Isolation and primary structure of rat secretin.

PubMed ID: 2719704

DOI: 10.1016/0006-291x(89)92514-x

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 7958688

Title: Dual inhibitory mechanism of secretin action on acid secretion in totally isolated, vascularly perfused rat stomach.

PubMed ID: 7958688

DOI: 10.1016/0016-5085(94)90817-6

PubMed ID: 8568688

Title: The mechanism of inhibitory action of secretin on gastric acid secretion in conscious rats.

PubMed ID: 8568688

DOI: 10.1113/jphysiol.1995.sp020984

PubMed ID: 3047699

Title: Effect of the secretin family of peptides on gastric emptying and small intestinal transit in rats.

PubMed ID: 3047699

DOI: 10.1016/0196-9781(88)90168-4

PubMed ID: 9655680

Title: Secretin inhibits gastric acid secretion via a vagal afferent pathway in rats.

PubMed ID: 9655680

DOI: 10.1152/ajpgi.1998.275.1.g22

PubMed ID: 9506976

Title: A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor.

PubMed ID: 9506976

DOI: 10.1074/jbc.273.12.6756

PubMed ID: 12403838

Title: Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus.

PubMed ID: 12403838

DOI: 10.1210/me.2002-0111

PubMed ID: 15276242

Title: Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain.

PubMed ID: 15276242

DOI: 10.1016/j.neulet.2004.05.030

PubMed ID: 19805236

Title: Secretin as a neurohypophysial factor regulating body water homeostasis.

PubMed ID: 19805236

DOI: 10.1073/pnas.0903695106

Sequence Information:

Length: 134
Mass: 15072
Checksum: D9FA1A4C1F7C86E6
Sequence:

MEPLLPTPPL LLLLLLLLSS SFVLPAPPRT PRHSDGTFTS ELSRLQDSAR LQRLLQGLVG 
KRSEEDTENI PENSVARPKP LEDQLCLLWS NTQALQDWLL PRLSLDGSLS LWLPPGPRPA 
VDHSEWTETT RQPR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Sct

Associated with

Other Information

Secretin: structure of the precursor and tissue distribution of the mRNA. PubMed ID: 2315322

The secretin gene: evolutionary history, alternative splicing, and developmental regulation. PubMed ID: 1711228

The secretin precursor gene. Structure of the coding region and expression in the brain. PubMed ID: 2061329

Isolation and primary structure of rat secretin. PubMed ID: 2719704

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Dual inhibitory mechanism of secretin action on acid secretion in totally isolated, vascularly perfused rat stomach. PubMed ID: 7958688

The mechanism of inhibitory action of secretin on gastric acid secretion in conscious rats. PubMed ID: 8568688

Effect of the secretin family of peptides on gastric emptying and small intestinal transit in rats. PubMed ID: 3047699

Secretin inhibits gastric acid secretion via a vagal afferent pathway in rats. PubMed ID: 9655680

A role for receptor kinases in the regulation of class II G protein-coupled receptors. Phosphorylation and desensitization of the secretin receptor. PubMed ID: 9506976

Interaction among four residues distributed through the secretin pharmacophore and a focused region of the secretin receptor amino terminus. PubMed ID: 12403838

Age-related and regional differences in secretin and secretin receptor mRNA levels in the rat brain. PubMed ID: 15276242

Secretin as a neurohypophysial factor regulating body water homeostasis. PubMed ID: 19805236