Genular: Defining Cellular Identity and Function

Details for: Slc9a1

Gene ID: 24782

Symbol: Slc9a1

Ensembl ID: ENSRNOG00000007982

Description: solute carrier family 9 member A1

Associated with

Glycosaminoglycan metabolism
(R-RNO-1630316)
Hyaluronan metabolism
(R-RNO-2142845)
Hyaluronan uptake and degradation
(R-RNO-2160916)
Metabolism
(R-RNO-1430728)
Metabolism of carbohydrates
(R-RNO-71387)
Slc-mediated transmembrane transport
(R-RNO-425407)
Sodium/proton exchangers
(R-RNO-425986)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-RNO-425393)
Transport of small molecules
(R-RNO-382551)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Calcium-dependent protein binding
(GO:0048306)
Calmodulin binding
(GO:0005516)
Cardiac muscle cell contraction
(GO:0086003)
Cardiac muscle cell differentiation
(GO:0055007)
Cation-transporting atpase complex
(GO:0090533)
Cell differentiation
(GO:0030154)
Cell surface
(GO:0009986)
Cellular response to acidic ph
(GO:0071468)
Cellular response to antibiotic
(GO:0071236)
Cellular response to cold
(GO:0070417)
Cellular response to electrical stimulus
(GO:0071257)
Cellular response to epinephrine stimulus
(GO:0071872)
Cellular response to hypoxia
(GO:0071456)
Cellular response to insulin stimulus
(GO:0032869)
Cellular response to organic cyclic compound
(GO:0071407)
Cytoplasm
(GO:0005737)
Identical protein binding
(GO:0042802)
Intercalated disc
(GO:0014704)
Intracellular sodium ion homeostasis
(GO:0006883)
Ion binding
(GO:0043167)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Mitochondrion
(GO:0005739)
Negative regulation of apoptotic process
(GO:0043066)
Nucleoplasm
(GO:0005654)
Perinuclear region of cytoplasm
(GO:0048471)
Phospholipid binding
(GO:0005543)
Plasma membrane
(GO:0005886)
Positive regulation of action potential
(GO:0045760)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of calcineurin-nfat signaling cascade
(GO:0070886)
Positive regulation of cardiac muscle hypertrophy
(GO:0010613)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of intracellular signal transduction
(GO:1902533)
Positive regulation of mitochondrial membrane permeability
(GO:0035794)
Positive regulation of the force of heart contraction
(GO:0098735)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Potassium:proton antiporter activity
(GO:0015386)
Potassium ion transmembrane transport
(GO:0071805)
Protein binding
(GO:0005515)
Protein phosphatase 2b binding
(GO:0030346)
Proton transmembrane transport
(GO:1902600)
Regulation of cardiac muscle contraction by calcium ion signaling
(GO:0010882)
Regulation of intracellular ph
(GO:0051453)
Regulation of ph
(GO:0006885)
Regulation of the force of heart contraction
(GO:0002026)
Regulation of the force of heart contraction by cardiac conduction
(GO:0086092)
Response to acidic ph
(GO:0010447)
Response to muscle stretch
(GO:0035994)
Response to organic cyclic compound
(GO:0014070)
Sarcolemma
(GO:0042383)
Sodium:proton antiporter activity
(GO:0015385)
Sodium ion export across plasma membrane
(GO:0036376)
Sodium ion import across plasma membrane
(GO:0098719)
Sodium ion transport
(GO:0006814)
Stem cell differentiation
(GO:0048863)
T-tubule
(GO:0030315)
Transporter complex
(GO:1990351)

Other Information

Proteins

Sodium/hydrogen exchanger 1

Genular Protein ID: 2910512367

Symbol: SL9A1_RAT

Name: Sodium/hydrogen exchanger 1

UniProtKB Accession Codes:

P26431

Database IDs:

Citations:

PubMed ID: 1577762

Title: Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins.

PubMed ID: 1577762

DOI: 10.1016/s0021-9258(19)50428-8

PubMed ID: 6334130

Title: 22Na+ fluxes in thymic lymphocytes. II. Amiloride-sensitive Na+/H+ exchange pathway; reversibility of transport and asymmetry of the modifier site.

PubMed ID: 6334130

DOI: 10.1085/jgp.84.4.585

PubMed ID: 9688597

Title: Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage.

PubMed ID: 9688597

DOI: 10.1152/ajpcell.1998.275.2.c431

PubMed ID: 10893269

Title: Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate.

PubMed ID: 10893269

DOI: 10.1083/jcb.150.1.213

PubMed ID: 11163215

Title: Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation.

PubMed ID: 11163215

DOI: 10.1016/s1097-2765(00)00139-8

PubMed ID: 12576672

Title: Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium.

PubMed ID: 12576672

DOI: 10.1248/bpb.26.148

PubMed ID: 18321853

Title: Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform.

PubMed ID: 18321853

DOI: 10.1074/jbc.m800267200

PubMed ID: 21543739

Title: Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1.

PubMed ID: 21543739

DOI: 10.1152/ajpcell.00404.2010

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 34774621

Title: Sodium hydrogen exchanger (NHE1) palmitoylation and potential functional regulation.

PubMed ID: 34774621

DOI: 10.1016/j.lfs.2021.120142

Sequence Information:

Length: 820
Mass: 91647
Checksum: 58398DE74A9642FB
Sequence:

MMLRWSGIWG LYPPRIFPSL LVVVALVGLL PVLRSHGLQL NPTASTIRGS EPPRERSIGD 
VTTAPSEPLH HPDDRNLTNL YIEHGAKPVR KAFPVLDIDY LHVRTPFEIS LWILLACLMK 
IGFHVIPTIS SIVPESCLLI VVGLLVGGLI KGVGETPPFL QSDVFFLFLL PPIILDAGYF 
LPLRQFTENL GTILIFAVVG TLWNAFFLGG LLYAVCLVGG EQINNIGLLD TLLFGSIISA 
VDPVAVLAVF EEIHINELLH ILVFGESLLN DAVTVVLYHL FEEFASYEYV GISDIFLGFL 
SFFVVSLGGV FVGVVYGVIA AFTSRFTSHI RVIEPLFVFL YSYMAYLSAE LFHLSGIMAL 
IASGVVMRPY VEANISHKSH TTIKYFLKMW SSVSETLIFI FLGVSTVAGS HQWNWTFVIS 
TLLFCLIARV LGVLVLTWFI NKFRIVKLTP KDQFIIAYGG LRGAIAFSLG YLLDKKHFPM 
CDLFLTAIIT VIFFTVFVQG MTIRPLVDLL AVKKKQETKR SINEEIHTQF LDHLLTGIED 
ICGHYGHHHW KDKLNRFNKK YVKKCLIAGE RSKEPQLIAF YHKMEMKQAI ELVESGGMGK 
IPSAVSTVSM QNIHPKSAAS ERILPALSKD KEEEIRKILR SNLQKTRQRL RSYNRHTLVA 
DPYEEAWNQM LLRRQKARQL EQKITNYLTV PAHKLDSPTM SRARIGSDPL AYEPKADLPV 
ITIDPASPQS PESVDLVNEE LKGKVLGLKR GPRTTPEEEE EDEDGVIMIR SKEPSSPGTD 
DVFTPGPSDS PGSQRIQRCL SDPGPHPEPG EGEPFIPKGQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc9a1

Associated with

Other Information

Molecular cloning of putative members of the Na/H exchanger gene family. cDNA cloning, deduced amino acid sequence, and mRNA tissue expression of the rat Na/H exchanger NHE-1 and two structurally related proteins. PubMed ID: 1577762

22Na+ fluxes in thymic lymphocytes. II. Amiloride-sensitive Na+/H+ exchange pathway; reversibility of transport and asymmetry of the modifier site. PubMed ID: 6334130

Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage. PubMed ID: 9688597

Intracellular pH regulation by Na(+)/H(+) exchange requires phosphatidylinositol 4,5-bisphosphate. PubMed ID: 10893269

Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation. PubMed ID: 11163215

Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium. PubMed ID: 12576672

Calcineurin B homologous protein 3 promotes the biosynthetic maturation, cell surface stability, and optimal transport of the Na+/H+ exchanger NHE1 isoform. PubMed ID: 18321853

Dual functional significance of calcineurin homologous protein 1 binding to Na(+)/H(+) exchanger isoform 1. PubMed ID: 21543739

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Sodium hydrogen exchanger (NHE1) palmitoylation and potential functional regulation. PubMed ID: 34774621