Details for: ALPI

Gene ID: 248

Symbol: ALPI

Ensembl ID: ENSG00000163295

Description: alkaline phosphatase, intestinal

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8273
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.76
    Marker Score: 6839
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3175
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.81
    Marker Score: 3126
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.76
    Marker Score: 2719
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.35
    Marker Score: 390
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.33
    Marker Score: 1489
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7639
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71824
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48049
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 514
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 467
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.95
    Marker Score: 379
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5330
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.92
    Marker Score: 330
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.87
    Marker Score: 4199
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.85
    Marker Score: 490
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 402
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.74
    Marker Score: 1187
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2858
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.68
    Marker Score: 1282
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.57
    Marker Score: 542
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 452
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.57
    Marker Score: 147
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.56
    Marker Score: 8729
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.55
    Marker Score: 371
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.54
    Marker Score: 1108
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.54
    Marker Score: 525
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 281
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.42
    Marker Score: 102
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.4
    Marker Score: 355
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.37
    Marker Score: 236
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.36
    Marker Score: 2136
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.35
    Marker Score: 167
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 138
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.33
    Marker Score: 394
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.3
    Marker Score: 180
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.29
    Marker Score: 292
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.28
    Marker Score: 161.5
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 564
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.25
    Marker Score: 68
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.24
    Marker Score: 756
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 70
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2
    Marker Score: 77
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.2
    Marker Score: 94
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.2
    Marker Score: 63
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.19
    Marker Score: 181
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.16
    Marker Score: 51
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.16
    Marker Score: 39
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.15
    Marker Score: 346
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.14
    Marker Score: 145
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.13
    Marker Score: 213
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.13
    Marker Score: 87
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.11
    Marker Score: 353
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.11
    Marker Score: 25
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.1
    Marker Score: 60
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1
    Marker Score: 26
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.1
    Marker Score: 112
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 0.09
    Marker Score: 23
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.09
    Marker Score: 65
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.09
    Marker Score: 43
  • Cell Name: GIP cell (CL0002278)
    Fold Change: 0.08
    Marker Score: 25
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.08
    Marker Score: 64
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.08
    Marker Score: 179
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.07
    Marker Score: 22
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.06
    Marker Score: 26
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.06
    Marker Score: 104
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.06
    Marker Score: 20
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.06
    Marker Score: 16
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.05
    Marker Score: 25
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.05
    Marker Score: 18
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.05
    Marker Score: 24
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.05
    Marker Score: 32
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.05
    Marker Score: 475
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.04
    Marker Score: 73

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Other Information

**Key characteristics:** * The ALPI gene is located on chromosome 19p13.2. * It is a large gene encoding for a protein of 1,650 amino acids. * The protein is a glycoprotein that is present in plasma and intracellular compartments. * It is a member of the alkaline phosphatase family of enzymes. **Pathways and functions:** * The ALPI protein is involved in a variety of cellular processes, including: * Alkaline phosphatase activity * Dephosphorylation * Digestion * Digestion and absorption * Extracellular region * Glycerophospholipid biosynthesis * Magnesium ion binding * Metabolism * Phospholipid metabolism * Plasma membrane * Post-translational modification * Protease binding * Protein binding * The protein is also involved in the regulation of inflammation and immune responses. **Clinical significance:** * Mutations in the ALPI gene have been linked to several human diseases, including: * Colorectal cancer * Inflammatory bowel disease * Liver disease * Hypertension * Diabetes * ALPI is a potential target for therapeutic intervention in these diseases. **Additional notes:** * The ALPI protein is a highly conserved protein with significant expression in the human intestine. * It is a key enzyme in the digestion of dietary fiber and the metabolism of lipids. * Mutations in the ALPI gene have been shown to disrupt the regulation of intestinal permeability and inflammation.

Genular Protein ID: 2563141360

Symbol: PPBI_HUMAN

Name: Intestinal-type alkaline phosphatase

UniProtKB Accession Codes:

P09923 B2R7Y4 Q53S80 Q9UBV5 Q9UCL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 2 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3468508

Title: Cloning and sequencing of human intestinal alkaline phosphatase cDNA.

PubMed ID: 3468508

DOI: 10.1073/pnas.84.3.695

PubMed ID: 3469665

Title: Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase.

PubMed ID: 3469665

DOI: 10.1073/pnas.84.5.1234

PubMed ID: 2841341

Title: Sequence and characterization of the human intestinal alkaline phosphatase gene.

PubMed ID: 2841341

DOI: 10.1016/s0021-9258(18)37886-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3697102

Title: Promoter structure of the human intestinal alkaline phosphatase gene.

PubMed ID: 3697102

DOI: 10.1093/nar/15.24.10599

PubMed ID: 3443302

Title: Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.

PubMed ID: 3443302

DOI: 10.1016/0378-1119(87)90235-6

PubMed ID: 3458202

Title: Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes.

PubMed ID: 3458202

DOI: 10.1073/pnas.83.8.2368

PubMed ID: 1458595

Title: Chemical nature of intestinal-type alkaline phosphatase in human kidney.

PubMed ID: 1458595

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 528
  • Mass: 56812
  • Checksum: 465306BEDF9F0B79
  • Sequence:
    • MQGPWVLLLL GLRLQLSLGV IPAEEENPAF WNRQAAEALD AAKKLQPIQK VAKNLILFLG 
DGLGVPTVTA TRILKGQKNG KLGPETPLAM DRFPYLALSK TYNVDRQVPD SAATATAYLC 
GVKANFQTIG LSAAARFNQC NTTRGNEVIS VMNRAKQAGK SVGVVTTTRV QHASPAGTYA 
HTVNRNWYSD ADMPASARQE GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPADA 
SQNGIRLDGK NLVQEWLAKH QGAWYVWNRT ELMQASLDQS VTHLMGLFEP GDTKYEIHRD 
PTLDPSLMEM TEAALRLLSR NPRGFYLFVE GGRIDHGHHE GVAYQALTEA VMFDDAIERA 
GQLTSEEDTL TLVTADHSHV FSFGGYTLRG SSIFGLAPSK AQDSKAYTSI LYGNGPGYVF 
NSGVRPDVNE SESGSPDYQQ QAAVPLSSET HGGEDVAVFA RGPQAHLVHG VQEQSFVAHV 
MAFAACLEPY TACDLAPPAC TTDAAHPVAA SLPLLAGTLL LLGASAAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.