Details for: ALPI

Gene ID: 248

Symbol: ALPI

Ensembl ID: ENSG00000163295

Description: alkaline phosphatase, intestinal

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 8.3877
    Cell Significance Index: -3.9600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 6.7251
    Cell Significance Index: 100.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 5.0208
    Cell Significance Index: -13.4500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 2.5389
    Cell Significance Index: 73.1500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.2099
    Cell Significance Index: 9.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.7511
    Cell Significance Index: 45.0900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6068
    Cell Significance Index: 547.8500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4261
    Cell Significance Index: 46.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3524
    Cell Significance Index: 24.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3148
    Cell Significance Index: 14.2700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2872
    Cell Significance Index: 46.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2377
    Cell Significance Index: 23.5100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2223
    Cell Significance Index: 42.3000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1172
    Cell Significance Index: 13.4300
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.0823
    Cell Significance Index: 1.2400
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.0265
    Cell Significance Index: 0.4400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0244
    Cell Significance Index: 0.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0219
    Cell Significance Index: 0.7700
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0164
    Cell Significance Index: 0.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0043
    Cell Significance Index: 0.0500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0005
    Cell Significance Index: -0.0200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.0012
    Cell Significance Index: -0.0100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.0030
    Cell Significance Index: -0.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0055
    Cell Significance Index: -3.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0063
    Cell Significance Index: -3.5700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0088
    Cell Significance Index: -0.5400
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0092
    Cell Significance Index: -0.1200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0115
    Cell Significance Index: -0.2500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0115
    Cell Significance Index: -0.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0118
    Cell Significance Index: -2.3700
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0129
    Cell Significance Index: -0.0800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0142
    Cell Significance Index: -10.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0160
    Cell Significance Index: -3.1700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0199
    Cell Significance Index: -2.3500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0269
    Cell Significance Index: -3.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0287
    Cell Significance Index: -3.3400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0293
    Cell Significance Index: -0.3500
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0324
    Cell Significance Index: -0.4100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0342
    Cell Significance Index: -0.7300
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0383
    Cell Significance Index: -0.4500
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0446
    Cell Significance Index: -0.4700
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0510
    Cell Significance Index: -0.6200
  • Cell Name: colonocyte (CL1000347)
    Fold Change: -0.0534
    Cell Significance Index: -0.3300
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.0590
    Cell Significance Index: -0.4100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0685
    Cell Significance Index: -1.4200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0745
    Cell Significance Index: -7.6200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0760
    Cell Significance Index: -2.0700
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.0895
    Cell Significance Index: -0.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0918
    Cell Significance Index: -2.4500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1112
    Cell Significance Index: -2.3600
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.1141
    Cell Significance Index: -1.3600
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.1162
    Cell Significance Index: -1.5200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1192
    Cell Significance Index: -3.2000
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1257
    Cell Significance Index: -3.2000
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.1259
    Cell Significance Index: -1.2200
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: -0.1272
    Cell Significance Index: -1.0300
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1273
    Cell Significance Index: -1.3700
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: -0.1317
    Cell Significance Index: -1.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1328
    Cell Significance Index: -10.5200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1358
    Cell Significance Index: -3.2900
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1539
    Cell Significance Index: -1.9500
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.1561
    Cell Significance Index: -2.3100
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: -0.1618
    Cell Significance Index: -1.7400
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: -0.1623
    Cell Significance Index: -1.6400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1672
    Cell Significance Index: -3.2700
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1687
    Cell Significance Index: -1.1700
  • Cell Name: myelocyte (CL0002193)
    Fold Change: -0.1703
    Cell Significance Index: -1.8200
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.1736
    Cell Significance Index: -1.0900
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.1759
    Cell Significance Index: -2.1000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.1779
    Cell Significance Index: -1.7600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1782
    Cell Significance Index: -5.2500
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: -0.1822
    Cell Significance Index: -1.7800
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: -0.1836
    Cell Significance Index: -1.9100
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.1846
    Cell Significance Index: -0.8500
  • Cell Name: peptic cell (CL0000155)
    Fold Change: -0.1857
    Cell Significance Index: -1.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1922
    Cell Significance Index: -1.9500
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1954
    Cell Significance Index: -2.6800
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1978
    Cell Significance Index: -2.5600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.1989
    Cell Significance Index: -1.3200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2019
    Cell Significance Index: -3.2700
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.2033
    Cell Significance Index: -2.8200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2042
    Cell Significance Index: -2.2300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.2080
    Cell Significance Index: -2.3800
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: -0.2090
    Cell Significance Index: -1.6700
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -0.2121
    Cell Significance Index: -2.1400
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: -0.2127
    Cell Significance Index: -1.9000
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: -0.2141
    Cell Significance Index: -2.8100
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: -0.2159
    Cell Significance Index: -1.8600
  • Cell Name: neutrophil (CL0000775)
    Fold Change: -0.2177
    Cell Significance Index: -2.7200
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.2239
    Cell Significance Index: -2.8300
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: -0.2346
    Cell Significance Index: -1.9800
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.2393
    Cell Significance Index: -2.5200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2402
    Cell Significance Index: -12.5100
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: -0.2448
    Cell Significance Index: -2.6500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.2468
    Cell Significance Index: -2.5600
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.2492
    Cell Significance Index: -2.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.2528
    Cell Significance Index: -3.6700
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.2532
    Cell Significance Index: -2.3500
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.2567
    Cell Significance Index: -2.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** ALPI is predominantly expressed in enterocytes, goblet cells, and other cells lining the intestinal epithelium, indicating its role in maintaining the intestinal barrier function. 2. **Enzymatic Activity:** ALPI is a type II transmembrane enzyme that catalyzes the dephosphorylation of various substrates, including phospholipids, proteins, and other metabolites. 3. **Subcellular Localization:** ALPI is primarily localized to the apical membrane of enterocytes, where it plays a crucial role in regulating the intestinal barrier function. **Pathways and Functions:** 1. **Digestion and Absorption:** ALPI is involved in regulating the levels of various ions and metabolites, including calcium, magnesium, and vitamin D, which are essential for proper digestion and absorption. 2. **Glycerophospholipid Biosynthesis:** ALPI is involved in the synthesis of glycerophospholipids, which are crucial components of cellular membranes. 3. **Metabolism of Lipids and Proteins:** ALPI regulates the levels of various lipids and proteins, including phospholipids, which are essential for maintaining cellular homeostasis. 4. **Zinc Ion Binding:** ALPI is capable of binding zinc ions, which is essential for its enzymatic activity. **Clinical Significance:** 1. **Intestinal Barrier Dysfunction:** Alterations in ALPI expression or activity have been linked to intestinal barrier dysfunction, which can lead to various diseases, including inflammatory bowel disease (IBD) and celiac disease. 2. **Gastrointestinal Disorders:** ALPI has been implicated in the pathogenesis of various gastrointestinal disorders, including IBD, celiac disease, and Crohn's disease. 3. **Nutritional Deficiencies:** ALPI plays a crucial role in regulating the levels of various ions and metabolites, which are essential for proper nutrient absorption. Alterations in ALPI expression or activity can lead to nutritional deficiencies. 4. **Cancer and Infection:** ALPI has been implicated in the pathogenesis of various cancers and infections, including colon cancer and enteric infections. In conclusion, ALPI is a crucial gene that plays a pivotal role in maintaining the intestinal homeostasis. Its dysregulation has been linked to various gastrointestinal disorders, including IBD, celiac disease, and Crohn's disease. Further research is needed to fully understand the mechanisms by which ALPI regulates the intestinal barrier function and to develop novel therapeutic strategies for the treatment of gastrointestinal disorders.

Genular Protein ID: 2563141360

Symbol: PPBI_HUMAN

Name: Intestinal-type alkaline phosphatase

UniProtKB Accession Codes:

P09923 B2R7Y4 Q53S80 Q9UBV5 Q9UCL2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 21 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 DrugCentral 1 EC 2 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 Rhea 1 SABIO-RK 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3468508

Title: Cloning and sequencing of human intestinal alkaline phosphatase cDNA.

PubMed ID: 3468508

DOI: 10.1073/pnas.84.3.695

PubMed ID: 3469665

Title: Nucleotide and amino acid sequences of human intestinal alkaline phosphatase: close homology to placental alkaline phosphatase.

PubMed ID: 3469665

DOI: 10.1073/pnas.84.5.1234

PubMed ID: 2841341

Title: Sequence and characterization of the human intestinal alkaline phosphatase gene.

PubMed ID: 2841341

DOI: 10.1016/s0021-9258(18)37886-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3697102

Title: Promoter structure of the human intestinal alkaline phosphatase gene.

PubMed ID: 3697102

DOI: 10.1093/nar/15.24.10599

PubMed ID: 3443302

Title: Two gene duplication events in the evolution of the human heat-stable alkaline phosphatases.

PubMed ID: 3443302

DOI: 10.1016/0378-1119(87)90235-6

PubMed ID: 3458202

Title: Partial sequencing of human adult, human fetal, and bovine intestinal alkaline phosphatases: comparison with the human placental and liver isozymes.

PubMed ID: 3458202

DOI: 10.1073/pnas.83.8.2368

PubMed ID: 1458595

Title: Chemical nature of intestinal-type alkaline phosphatase in human kidney.

PubMed ID: 1458595

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

Sequence Information:

  • Length: 528
  • Mass: 56812
  • Checksum: 465306BEDF9F0B79
  • Sequence:
    • MQGPWVLLLL GLRLQLSLGV IPAEEENPAF WNRQAAEALD AAKKLQPIQK VAKNLILFLG 
DGLGVPTVTA TRILKGQKNG KLGPETPLAM DRFPYLALSK TYNVDRQVPD SAATATAYLC 
GVKANFQTIG LSAAARFNQC NTTRGNEVIS VMNRAKQAGK SVGVVTTTRV QHASPAGTYA 
HTVNRNWYSD ADMPASARQE GCQDIATQLI SNMDIDVILG GGRKYMFPMG TPDPEYPADA 
SQNGIRLDGK NLVQEWLAKH QGAWYVWNRT ELMQASLDQS VTHLMGLFEP GDTKYEIHRD 
PTLDPSLMEM TEAALRLLSR NPRGFYLFVE GGRIDHGHHE GVAYQALTEA VMFDDAIERA 
GQLTSEEDTL TLVTADHSHV FSFGGYTLRG SSIFGLAPSK AQDSKAYTSI LYGNGPGYVF 
NSGVRPDVNE SESGSPDYQQ QAAVPLSSET HGGEDVAVFA RGPQAHLVHG VQEQSFVAHV 
MAFAACLEPY TACDLAPPAC TTDAAHPVAA SLPLLAGTLL LLGASAAP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.