Genular: Defining Cellular Identity and Function

Details for: Tap2

Gene ID: 24812

Symbol: Tap2

Ensembl ID: ENSRNOG00000000455

Description: transporter 2, ATP binding cassette subfamily B member

Associated with

Adaptive immune system
(R-RNO-1280218)
Antigen presentation: folding, assembly and peptide loading of class i mhc
(R-RNO-983170)
Antigen processing-cross presentation
(R-RNO-1236975)
Class i mhc mediated antigen processing & presentation
(R-RNO-983169)
Er-phagosome pathway
(R-RNO-1236974)
Immune system
(R-RNO-168256)
Abc-type peptide antigen transporter activity
(GO:0015433)
Abc-type peptide transporter activity
(GO:0015440)
Adp binding
(GO:0043531)
Antigen processing and presentation of endogenous peptide antigen via mhc class i
(GO:0019885)
Antigen processing and presentation of endogenous peptide antigen via mhc class ib via er pathway, tap-dependent
(GO:0002489)
Antigen processing and presentation of endogenous peptide antigen via mhc class i via er pathway, tap-dependent
(GO:0002485)
Antigen processing and presentation of exogenous protein antigen via mhc class ib, tap-dependent
(GO:0002481)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cytosol to endoplasmic reticulum transport
(GO:0046967)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum membrane
(GO:0005789)
Identical protein binding
(GO:0042802)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mhc class ib protein binding
(GO:0023029)
Mhc class i peptide loading complex
(GO:0042824)
Mhc class i protein binding
(GO:0042288)
Nuclear speck
(GO:0016607)
Nucleotide binding
(GO:0000166)
Peptide antigen binding
(GO:0042605)
Peptide antigen transport
(GO:0046968)
Peptide transmembrane transporter activity
(GO:1904680)
Peptide transport
(GO:0015833)
Positive regulation of antigen processing and presentation of peptide antigen via mhc class i
(GO:0002591)
Positive regulation of t cell mediated cytotoxicity
(GO:0001916)
Protection from natural killer cell mediated cytotoxicity
(GO:0042270)
Protein-containing complex assembly
(GO:0065003)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein transport
(GO:0015031)
Response to molecule of bacterial origin
(GO:0002237)
Tap1 binding
(GO:0046978)
Tap2 binding
(GO:0046979)
Tapasin binding
(GO:0046980)
Tap complex
(GO:0042825)
T cell mediated cytotoxicity
(GO:0001913)
Transmembrane transport
(GO:0055085)

Other Information

Proteins

Antigen peptide transporter 2
Q6MGA3_RAT

Genular Protein ID: 2297033711

Symbol: TAP2_RAT

Name: Antigen peptide transporter 2

UniProtKB Accession Codes:

P36372

Database IDs:

Citations:

PubMed ID: 1758495

Title: Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter.

PubMed ID: 1758495

DOI: 10.1038/354528a0

PubMed ID: 1350326

Title: Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule.

PubMed ID: 1350326

DOI: 10.1038/357211a0

PubMed ID: 8206525

Title: The distribution of Tap2 alleles among laboratory rat RT1 haplotypes.

PubMed ID: 8206525

DOI: 10.1007/bf00163963

PubMed ID: 17018292

Title: Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter.

PubMed ID: 17018292

DOI: 10.1016/j.molcel.2006.07.034

Sequence Information:

Length: 703
Mass: 77713
Checksum: E545993A8F784250
Sequence:

MALSHPRPWA SLLLVDLALL GLLQSSLGTL LPPGLPGLWL EGTLRLGVLW GLLKVGGLLR 
LVGTFLPLLC LTNPLFFSLR ALVGSTMSTS VVRVASASWG WLLADYGAVA LSLAVWAVLS 
PAGAQEKEPG QENNRALMIR LLRLSKPDLP FLIVAFIFLA MAVWWEMFIP HYSGRVIDIL 
GGDFDPDAFA SAIFFMCLFS VGSSLSAGCR GGSFLFAESR INLRIREQLF SSLLRQDLAF 
FQETKTGELN SRLSSDTSLM SQWLSLNANI LLRSLVKVVG LYYFMLQVSP RLTFLSLLDL 
PLTIAAEKVY NPRHQAVLKE IQDAVAKAGQ VVREAVGGLQ TVRSFGAEEQ EVRRYKEALE 
RCRQLWWRRD LEKSLYLVIQ RVMALGMQVL ILNVGVQQIL AGEVTRGGLL SFLLYQEEVG 
HHVQNLVYMY GDMLSNVGAA EKVFSYLDRR PNLPNPGTLA PPRLEGRVEF QDVSFSYPSR 
PEKPVLQGLT FTLHPGKVTA LVGPNGSGKS TVAALLQNLY QPTGGQLLLD GEPLVQYDHH 
YLHRQVVLVG QEPVLFSGSV KDNIAYGLRD CEDAQVMAAA QAACADDFIG EMTNGINTEI 
GEKGSQLAVG QKQRLAIARA LVRNPRVLIL DEATSALDAE CEQALQTWRS QEDRTMLVIA 
HRLHTVQNAD QVLVLKQGQL VEHDQLRDEQ DVYAHLVQQR LEA

Genular Protein ID: 4038285712

Symbol: Q6MGA3_RAT

Name: N/A

UniProtKB Accession Codes:

Q6MGA3 A6JJD9

Database IDs:

Citations:

PubMed ID: 15060004

Title: The genomic sequence and comparative analysis of the rat major histocompatibility complex.

PubMed ID: 15060004

DOI: 10.1101/gr.1987704

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

PubMed ID: 24586191

Title: Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat.

PubMed ID: 24586191

DOI: 10.1371/journal.pgen.1004151

Sequence Information:

Length: 703
Mass: 77750
Checksum: 0BEC633ED139E5FF
Sequence:

MALSYPRPWA SLLLVDLALL GLLQRSLGTL LPPGLPGLWL EGTLRLGVLW GLLKVGGLLR 
LVGTFLPLLC LTTPLFFSLR ALVGSTMSTS VLRVASASWG WLLAGYVAAA LSLAVWAVLS 
PAGAQEKEPG QENNRALMIR LLRLSKPDLP FLIVAFIFLA MAVWGETLIP HYSGRVIDIL 
GGDFDPDAFA SAIFFMCLFS VGSSLSAGCR GGSFLFTMSR INLRIREQLF SSLLRQDLAF 
FQETKTGELN SRLSSDTSLM SRWLPFNANI LLRSLVKVVG LYYFMLQVSP RLTFLSLLDL 
PLTIAAEKVY NPRHQAVLKE IQDVVAKAGQ VVREAVGGLQ TVRSFGAEEQ EVSRYKEALE 
RCRQLWWRRD LEKELYLVIR RVMALGMQVL ILNCGVQQIL AGEVTRGGLL SFLLYQEEVG 
HHVRNLVYMY GDMLSNVGAA EKVFSYLDRR PNLPKPGTLA PPRVEGRVEF QDVSFSYPSR 
PEKPVLQGLT FTLHPGKVTA LVGPNGSGKS TVAALLQNLY QPTGGKVLLD GEPLVQYDHH 
YLHRQVVLVG QEPVLFSGSV KDNIAYGLRN CEDAQVMAAA QAACADDFIG EMTNGINTEI 
GERGSQLAVG QKQRLAIARA LVRNPRVLIL DEATSALDAE CEQALQTWRS QEDRTMLVIA 
HRLHTVQNAD QVLVLKQGQL VEHDQLRDEQ DVYAHLVQQR LEA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tap2

Associated with

Other Information

Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter. PubMed ID: 1758495

Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule. PubMed ID: 1350326

The distribution of Tap2 alleles among laboratory rat RT1 haplotypes. PubMed ID: 8206525

Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. PubMed ID: 17018292

The genomic sequence and comparative analysis of the rat major histocompatibility complex. PubMed ID: 15060004

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Natural polymorphisms in Tap2 influence negative selection and CD4?CD8 lineage commitment in the rat. PubMed ID: 24586191