Genular: Defining Cellular Identity and Function

Details for: Hnf1a

Gene ID: 24817

Symbol: Hnf1a

Ensembl ID: ENSRNOG00000001183

Description: HNF1 homeobox A

Associated with

Apoptotic nuclear changes
(GO:0030262)
Bile acid and bile salt transport
(GO:0015721)
Bile acid biosynthetic process
(GO:0006699)
Blastocyst development
(GO:0001824)
Bone resorption
(GO:0045453)
Cellular response to glucose stimulus
(GO:0071333)
Cellular response to leucine
(GO:0071233)
Cellular response to rapamycin
(GO:0072752)
Cholesterol metabolic process
(GO:0008203)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Embryonic limb morphogenesis
(GO:0030326)
Fatty acid biosynthetic process
(GO:0006633)
Fatty acid transport
(GO:0015908)
Glucose homeostasis
(GO:0042593)
Glucose import
(GO:0046323)
Heme biosynthetic process
(GO:0006783)
Identical protein binding
(GO:0042802)
Insulin secretion
(GO:0030073)
Liver development
(GO:0001889)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of mirna processing
(GO:1903799)
Negative regulation of peptidyl-threonine phosphorylation
(GO:0010801)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Pancreas development
(GO:0031016)
Paraxial mesoderm formation
(GO:0048341)
Photoreceptor outer segment
(GO:0001750)
Placenta development
(GO:0001890)
Positive regulation of atp biosynthetic process
(GO:2001171)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of mitochondrial membrane potential
(GO:0010918)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of transcription initiation by rna polymerase ii
(GO:0060261)
Pronucleus
(GO:0045120)
Protein-containing complex
(GO:0032991)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein localization
(GO:0008104)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of hormone secretion
(GO:0046883)
Regulation of nadp metabolic process
(GO:1902031)
Regulation of pronephros size
(GO:0035565)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of wnt signaling pathway
(GO:0030111)
Renal glucose absorption
(GO:0035623)
Reproductive structure development
(GO:0048608)
Response to glucose
(GO:0009749)
Response to oxidative stress
(GO:0006979)
Reverse cholesterol transport
(GO:0043691)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Transcription by rna polymerase ii
(GO:0006366)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coactivator binding
(GO:0001223)
Transcription coregulator binding
(GO:0001221)
Transcription regulator complex
(GO:0005667)

Other Information

Proteins

Hepatocyte nuclear factor 1-alpha

Genular Protein ID: 469973856

Symbol: HNF1A_RAT

Name: Hepatocyte nuclear factor 1-alpha

UniProtKB Accession Codes:

P15257

Database IDs:

Citations:

PubMed ID: 2571419

Title: The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain.

PubMed ID: 2571419

DOI: 10.1016/0092-8674(89)90877-5

PubMed ID: 2216777

Title: A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain.

PubMed ID: 2216777

DOI: 10.1093/nar/18.19.5853

PubMed ID: 7937157

Title: LFB1/HNF1 acts as a repressor of its own transcription.

PubMed ID: 7937157

DOI: 10.1093/nar/22.20.4284

PubMed ID: 1970973

Title: HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF.

PubMed ID: 1970973

DOI: 10.1101/gad.4.3.372

PubMed ID: 1354855

Title: Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1).

PubMed ID: 1354855

DOI: 10.1093/nar/20.16.4199

PubMed ID: 1967225

Title: The homeodomain of the transcription factor LF-B1 has a 21 amino acid loop between helix 2 and helix 3.

PubMed ID: 1967225

DOI: 10.1016/0092-8674(90)90708-m

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 1988016

Title: 1H resonance assignment and secondary structure determination of the dimerization domain of transcription factor LFB1.

PubMed ID: 1988016

DOI: 10.1021/bi00215a022

PubMed ID: 8491172

Title: The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain.

PubMed ID: 8491172

DOI: 10.1002/j.1460-2075.1993.tb05827.x

PubMed ID: 9126845

Title: The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor.

PubMed ID: 9126845

DOI: 10.1006/jmbi.1997.0905

PubMed ID: 8491173

Title: The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding.

PubMed ID: 8491173

DOI: 10.2210/pdb1lfb/pdb

Sequence Information:

Length: 628
Mass: 67213
Checksum: 8D28099308C86A52
Sequence:

MVSKLSQLQT ELLAALLESG LSKEALIQAL GEPGPYLMVG DGPLDKGESC GGTRGDLTEL 
PNGLGETRGS EDDTDDDGED FAPPILKELE NLSPEEAAHQ KAVVESLLQE DPWRVAKMVK 
SYLQQHNIPQ REVVDTTGLN QSHLSQHLNK GTPMKTQKRA ALYTWYVRKQ REVAQQFTHA 
GQGGLIEEPT GDELPTKKGR RNRFKWGPAS QQILFQAYER QKNPSKEERE TLVEECNRAE 
CIQRGVSPSQ AQGLGSNLVT EVRVYNWFAN RRKEEAFRHK LAMDTYNGPP PGPGPGPALP 
AHSSPGLPTT TLSPSKVHGV RYGQSATSEA AEVPSSSGGP LVTVSAALHQ VSPTGLEPSS 
LLSTEAKLVS ATGGPLPPVS TLTALHSLEQ TSPGLNQQPQ NLIMASLPGV MTIGPGEPAS 
LGPTFTNTGA STLVIGLAST QAQSVPVINS MGSSLTTLQP VQFSQPLHPS YQQPLMPPVQ 
SHVAQSPFMA TMAQLQSPHA LYSHKPEVAQ YTHTSLLPQT MLITDTNLST LASLTPTKQV 
FTSDTEASSE PGLHEPSSPA TTIHIPSQDP SNIQHLQPAH RLSTSPTVSS SSLVLYQSSD 
SNGHSHLLPS NHGVIETFIS TQMASSSQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hnf1a

Associated with

Other Information

The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. PubMed ID: 2571419

A distal dimerization domain is essential for DNA-binding by the atypical HNF1 homeodomain. PubMed ID: 2216777

LFB1/HNF1 acts as a repressor of its own transcription. PubMed ID: 7937157

HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. PubMed ID: 1970973

Structure of the gene encoding hepatocyte nuclear factor 1 (HNF1). PubMed ID: 1354855

The homeodomain of the transcription factor LF-B1 has a 21 amino acid loop between helix 2 and helix 3. PubMed ID: 1967225

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

1H resonance assignment and secondary structure determination of the dimerization domain of transcription factor LFB1. PubMed ID: 1988016

The three-dimensional NMR-solution structure of the polypeptide fragment 195-286 of the LFB1/HNF1 transcription factor from rat liver comprises a nonclassical homeodomain. PubMed ID: 8491172

The NMR solution structure of the non-classical homeodomain from the rat liver LFB1/HNF1 transcription factor. PubMed ID: 9126845

The X-ray structure of an atypical homeodomain present in the rat liver transcription factor LFB1/HNF1 and implications for DNA binding. PubMed ID: 8491173