Details for: Tnf

Gene ID: 24835

Symbol: Tnf

Ensembl ID: ENSRNOG00000070745

Description: tumor necrosis factor

Associated with

  • Cytokine signaling in immune system
    (R-RNO-1280215)
  • Death receptor signaling
    (R-RNO-73887)
  • Immune system
    (R-RNO-168256)
  • Regulation of tnfr1 signaling
    (R-RNO-5357905)
  • Signal transduction
    (R-RNO-162582)
  • Tnfr1-induced nf-kappa-b signaling pathway
    (R-RNO-5357956)
  • Tnfr1-induced proapoptotic signaling
    (R-RNO-5357786)
  • Tnfr1-mediated ceramide production
    (R-RNO-5626978)
  • Tnfr2 non-canonical nf-kb pathway
    (R-RNO-5668541)
  • Tnf signaling
    (R-RNO-75893)
  • Animal organ morphogenesis
    (GO:0009887)
  • Calcium-mediated signaling
    (GO:0019722)
  • Chronic inflammatory response to antigenic stimulus
    (GO:0002439)
  • Circadian rhythm
    (GO:0007623)
  • Cortical actin cytoskeleton organization
    (GO:0030866)
  • Cytokine activity
    (GO:0005125)
  • Death receptor agonist activity
    (GO:0038177)
  • Defense response
    (GO:0006952)
  • Defense response to bacterium
    (GO:0042742)
  • Extracellular matrix organization
    (GO:0030198)
  • Extrinsic apoptotic signaling pathway via death domain receptors
    (GO:0008625)
  • Glucose metabolic process
    (GO:0006006)
  • Humoral immune response
    (GO:0006959)
  • Identical protein binding
    (GO:0042802)
  • Immune response
    (GO:0006955)
  • Inflammatory response
    (GO:0006954)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Jnk cascade
    (GO:0007254)
  • Leukocyte migration involved in inflammatory response
    (GO:0002523)
  • Macrophage activation involved in immune response
    (GO:0002281)
  • Microglial cell activation
    (GO:0001774)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cytokine production involved in immune response
    (GO:0002719)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of heart rate
    (GO:0010459)
  • Negative regulation of interleukin-6 production
    (GO:0032715)
  • Negative regulation of l-glutamate import across plasma membrane
    (GO:0002037)
  • Negative regulation of myelination
    (GO:0031642)
  • Negative regulation of systemic arterial blood pressure
    (GO:0003085)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Osteoclast differentiation
    (GO:0030316)
  • Positive regulation of amide metabolic process
    (GO:0034250)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of chronic inflammatory response to antigenic stimulus
    (GO:0002876)
  • Positive regulation of cytokine production
    (GO:0001819)
  • Positive regulation of fever generation
    (GO:0031622)
  • Positive regulation of fractalkine production
    (GO:0032724)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of heterotypic cell-cell adhesion
    (GO:0034116)
  • Positive regulation of humoral immune response mediated by circulating immunoglobulin
    (GO:0002925)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of interleukin-18 production
    (GO:0032741)
  • Positive regulation of peptidyl-serine phosphorylation
    (GO:0033138)
  • Positive regulation of protein-containing complex assembly
    (GO:0031334)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of type ii interferon production
    (GO:0032729)
  • Positive regulation of tyrosine phosphorylation of stat protein
    (GO:0042531)
  • Protease binding
    (GO:0002020)
  • Receptor ligand activity
    (GO:0048018)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of immunoglobulin production
    (GO:0002637)
  • Regulation of protein phosphorylation
    (GO:0001932)
  • Response to activity
    (GO:0014823)
  • Response to bacterium
    (GO:0009617)
  • Response to fructose
    (GO:0009750)
  • Response to hypoxia
    (GO:0001666)
  • Response to isolation stress
    (GO:0035900)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to macrophage colony-stimulating factor
    (GO:0036005)
  • Response to mechanical stimulus
    (GO:0009612)
  • Response to nutrient levels
    (GO:0031667)
  • Response to organic cyclic compound
    (GO:0014070)
  • Response to organic substance
    (GO:0010033)
  • Response to virus
    (GO:0009615)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Sequestering of triglyceride
    (GO:0030730)
  • Skeletal muscle contraction
    (GO:0003009)
  • Toll-like receptor 3 signaling pathway
    (GO:0034138)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Tumor necrosis factor-mediated signaling pathway
    (GO:0033209)
  • Tumor necrosis factor receptor binding
    (GO:0005164)
  • Vascular endothelial growth factor production
    (GO:0010573)
  • Vasodilation
    (GO:0042311)

Other Information

Genular Protein ID: 1042394628

Symbol: TNFA_RAT

Name: Tumor necrosis factor

UniProtKB Accession Codes:

P16599 Q6EE11 Q9JI26 Q9JI27

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 BindingDB 1 CDD 1 CTD 1 DIP 1 EMBL 18 Ensembl 4 GO 100 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 6 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1

Citations:

PubMed ID: 1627266

Title: Rat tumor necrosis factor-alpha. Transcription in rat Kupffer cells and in vitro posttranslational processing based on a PCR-derived cDNA.

PubMed ID: 1627266

DOI: 10.1515/bchm3.1992.373.1.271

PubMed ID: 8224868

Title: Cloning and sequence analysis of the rat tumor necrosis factor-encoding genes.

PubMed ID: 8224868

DOI: 10.1016/0378-1119(93)90200-m

PubMed ID: 11477479

Title: Polymorphisms of the tumor necrosis factor alpha locus among autoimmune disease susceptible and resistant inbred rat strains.

PubMed ID: 11477479

DOI: 10.1038/sj.gene.6363761

PubMed ID: 15935297

Title: No association between tumor necrosis factor-alpha production and gene polymorphisms among inbred rat strains.

PubMed ID: 15935297

DOI: 10.1016/j.trim.2005.04.002

PubMed ID: 15060004

Title: The genomic sequence and comparative analysis of the rat major histocompatibility complex.

PubMed ID: 15060004

DOI: 10.1101/gr.1987704

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 235
  • Mass: 25806
  • Checksum: B808EC6D049C2F3B
  • Sequence:
    • MSTESMIRDV ELAEEALPKK MGGLQNSRRC LCLSLFSFLL VAGATTLFCL LNFGVIGPNK 
EEKFPNGLPL ISSMAQTLTL RSSSQNSSDK PVAHVVANHQ AEEQLEWLSQ RANALLANGM 
DLKDNQLVVP ADGLYLIYSQ VLFKGQGCPD YVLLTHTVSR FAISYQEKVS LLSAIKSPCP 
KDTPEGAELK PWYEPMYLGG VFQLEKGDLL SAEVNLPKYL DITESGQVYF GVIAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.