Genular: Defining Cellular Identity and Function

Details for: Tp53

Gene ID: 24842

Symbol: Tp53

Ensembl ID: ENSRNOG00000010756

Description: tumor protein p53

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-RNO-1169410)
Autodegradation of the e3 ubiquitin ligase cop1
(R-RNO-349425)
Cell cycle
(R-RNO-1640170)
Cell cycle, mitotic
(R-RNO-69278)
Cell cycle checkpoints
(R-RNO-69620)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular senescence
(R-RNO-2559583)
Cytokine signaling in immune system
(R-RNO-1280215)
Deubiquitination
(R-RNO-5688426)
Dna damage/telomere stress induced senescence
(R-RNO-2559586)
Dna double-strand break repair
(R-RNO-5693532)
Dna double strand break response
(R-RNO-5693606)
Dna repair
(R-RNO-73894)
G1/s dna damage checkpoints
(R-RNO-69615)
G2/m checkpoints
(R-RNO-69481)
G2/m dna damage checkpoint
(R-RNO-69473)
G2/m transition
(R-RNO-69275)
Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Immune system
(R-RNO-168256)
Interferon signaling
(R-RNO-913531)
Metabolism of proteins
(R-RNO-392499)
Mitotic g2-g2/m phases
(R-RNO-453274)
Oncogene induced senescence
(R-RNO-2559585)
Ovarian tumor domain proteases
(R-RNO-5689896)
Oxidative stress induced senescence
(R-RNO-2559580)
P53-dependent g1 dna damage response
(R-RNO-69563)
P53-dependent g1/s dna damage checkpoint
(R-RNO-69580)
Pi5p regulates tp53 acetylation
(R-RNO-6811555)
Pkr-mediated signaling
(R-RNO-9833482)
Post-translational protein modification
(R-RNO-597592)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-RNO-5693565)
Regulation of tp53 activity
(R-RNO-5633007)
Regulation of tp53 activity through acetylation
(R-RNO-6804758)
Regulation of tp53 activity through association with co-factors
(R-RNO-6804759)
Regulation of tp53 activity through methylation
(R-RNO-6804760)
Regulation of tp53 activity through phosphorylation
(R-RNO-6804756)
Regulation of tp53 degradation
(R-RNO-6804757)
Regulation of tp53 expression
(R-RNO-6804754)
Regulation of tp53 expression and degradation
(R-RNO-6806003)
Rna polymerase ii transcription
(R-RNO-73857)
Runx3 regulates cdkn1a transcription
(R-RNO-8941855)
Stabilization of p53
(R-RNO-69541)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-RNO-8852276)
Transcriptional activation of cell cycle inhibitor p21
(R-RNO-69895)
Transcriptional activation of p53 responsive genes
(R-RNO-69560)
Transcriptional regulation by runx3
(R-RNO-8878159)
Transcriptional regulation by tp53
(R-RNO-3700989)
Ub-specific processing proteases
(R-RNO-5689880)
14-3-3 protein binding
(GO:0071889)
Atp-dependent dna/dna annealing activity
(GO:0036310)
B cell lineage commitment
(GO:0002326)
Chromatin binding
(GO:0003682)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Copper ion binding
(GO:0005507)
Core promoter sequence-specific dna binding
(GO:0001046)
Disordered domain specific binding
(GO:0097718)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
General transcription initiation factor binding
(GO:0140296)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Histone deacetylase binding
(GO:0042826)
Histone deacetylase regulator activity
(GO:0035033)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Mdm2/mdm4 family protein binding
(GO:0097371)
Metal ion binding
(GO:0046872)
Mitophagy
(GO:0000423)
Molecular function activator activity
(GO:0140677)
Mrna 3'-utr binding
(GO:0003730)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
P53 binding
(GO:0002039)
Promoter-specific chromatin binding
(GO:1990841)
Protease binding
(GO:0002020)
Protein-folding chaperone binding
(GO:0051087)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein phosphatase 2a binding
(GO:0051721)
Protein self-association
(GO:0043621)
Receptor tyrosine kinase binding
(GO:0030971)
Release of cytochrome c from mitochondria
(GO:0001836)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Somitogenesis
(GO:0001756)
T cell proliferation involved in immune response
(GO:0002309)
Tfiid-class transcription factor complex binding
(GO:0001094)
Transcription cis-regulatory region binding
(GO:0000976)
Transcription coregulator binding
(GO:0001221)
Transmembrane transporter binding
(GO:0044325)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Cellular tumor antigen p53

Genular Protein ID: 535806003

Symbol: P53_RAT

Name: Cellular tumor antigen p53

UniProtKB Accession Codes:

P10361 O09168 Q4KMA9 Q66HM0

Database IDs:

Citations:

PubMed ID: 3060862

Title: Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein.

PubMed ID: 3060862

DOI: 10.1093/nar/16.23.11384

PubMed ID: 8441680

Title: Structure of the rat p53 tumor suppressor gene.

PubMed ID: 8441680

DOI: 10.1093/nar/21.3.713

PubMed ID: 9278438

Title: Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53.

PubMed ID: 9278438

DOI: 10.1074/jbc.272.36.22776

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663025

Title: Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell.

PubMed ID: 8663025

DOI: 10.1074/jbc.271.25.15084

PubMed ID: 22726440

Title: p53 opens the mitochondrial permeability transition pore to trigger necrosis.

PubMed ID: 22726440

DOI: 10.1016/j.cell.2012.05.014

Sequence Information:

Length: 391
Mass: 43451
Checksum: E62522313A5C872F
Sequence:

MEDSQSDMSI ELPLSQETFS CLWKLLPPDD ILPTTATGSP NSMEDLFLPQ DVAELLEGPE 
EALQVSAPAA QEPGTEAPAP VAPASATPWP LSSSVPSQKT YQGNYGFHLG FLQSGTAKSV 
MCTYSISLNK LFCQLAKTCP VQLWVTSTPP PGTRVRAMAI YKKSQHMTEV VRRCPHHERC 
SDGDGLAPPQ HLIRVEGNPY AEYLDDRQTF RHSVVVPYEP PEVGSDYTTI HYKYMCNSSC 
MGGMNRRPIL TIITLEDSSG NLLGRDSFEV RVCACPGRDR RTEEENFRKK EEHCPELPPG 
SAKRALPTST SSSPQQKKKP LDGEYFTLKI RGRERFEMFR ELNEALELKD ARAAEESGDS 
RAHSSYPKTK KGQSTSRHKK PMIKKVGPDS D

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tp53

Associated with

Other Information

Nucleotide sequence of a cDNA encoding the rat p53 nuclear oncoprotein. PubMed ID: 3060862

Structure of the rat p53 tumor suppressor gene. PubMed ID: 8441680

Glucose catabolism in cancer cells. The type II hexokinase promoter contains functionally active response elements for the tumor suppressor p53. PubMed ID: 9278438

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Heat shock protein 84 forms a complex with mutant p53 protein predominantly within a cytoplasmic compartment of the cell. PubMed ID: 8663025