Genular: Defining Cellular Identity and Function

Details for: Clu

Gene ID: 24854

Symbol: Clu

Ensembl ID: ENSRNOG00000016460

Description: clusterin

Associated with

Antimicrobial peptides
(R-RNO-6803157)
Complement cascade
(R-RNO-166658)
Hemostasis
(R-RNO-109582)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Platelet activation, signaling and aggregation
(R-RNO-76002)
Platelet degranulation
(R-RNO-114608)
Regulation of complement cascade
(R-RNO-977606)
Response to elevated platelet cytosolic ca2+
(R-RNO-76005)
Aggresome
(GO:0016235)
Amyloid-beta binding
(GO:0001540)
Apical dendrite
(GO:0097440)
Atp hydrolysis activity
(GO:0016887)
Cell morphogenesis
(GO:0000902)
Cell periphery
(GO:0071944)
Cell surface
(GO:0009986)
Cellular response to growth factor stimulus
(GO:0071363)
Central nervous system myelin maintenance
(GO:0032286)
Chaperone-mediated protein complex assembly
(GO:0051131)
Chaperone-mediated protein folding
(GO:0061077)
Chromaffin granule
(GO:0042583)
Collagen-containing extracellular matrix
(GO:0062023)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Endocrine pancreas development
(GO:0031018)
Endoplasmic reticulum
(GO:0005783)
Estrous cycle
(GO:0044849)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Golgi apparatus
(GO:0005794)
Growth cone
(GO:0030426)
Immune complex clearance
(GO:0002434)
Intracellular membrane-bounded organelle
(GO:0043231)
Intrinsic apoptotic signaling pathway
(GO:0097193)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Membrane
(GO:0016020)
Microglial cell activation
(GO:0001774)
Microglial cell proliferation
(GO:0061518)
Misfolded protein binding
(GO:0051787)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial membrane
(GO:0031966)
Mitochondrion
(GO:0005739)
Negative regulation of amyloid-beta formation
(GO:1902430)
Negative regulation of amyloid fibril formation
(GO:1905907)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of response to endoplasmic reticulum stress
(GO:1903573)
Neurofibrillary tangle
(GO:0097418)
Neuron projection morphogenesis
(GO:0048812)
Nucleus
(GO:0005634)
Perinuclear endoplasmic reticulum lumen
(GO:0099020)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of neurofibrillary tangle assembly
(GO:1902998)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Positive regulation of protein-containing complex assembly
(GO:0031334)
Positive regulation of receptor-mediated endocytosis
(GO:0048260)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein carrier chaperone
(GO:0140597)
Protein import
(GO:0017038)
Protein stabilization
(GO:0050821)
Protein targeting to lysosome involved in chaperone-mediated autophagy
(GO:0061740)
Regulation of amyloid-beta clearance
(GO:1900221)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell population proliferation
(GO:0042127)
Regulation of neuronal signal transduction
(GO:1902847)
Response to light stimulus
(GO:0009416)
Response to misfolded protein
(GO:0051788)
Response to potassium ion
(GO:0035864)
Response to virus
(GO:0009615)
Signaling receptor binding
(GO:0005102)
Spermatogenesis
(GO:0007283)
Spherical high-density lipoprotein particle
(GO:0034366)
Synapse
(GO:0045202)
Tau protein binding
(GO:0048156)
Ubiquitin protein ligase binding
(GO:0031625)
Unfolded protein binding
(GO:0051082)

Other Information

Proteins

Dimeric acid glycoprotein
A6K6L1_RAT

Genular Protein ID: 2038500944

Symbol: CLUS_RAT

Name: Dimeric acid glycoprotein

UniProtKB Accession Codes:

P05371

Database IDs:

Citations:

PubMed ID: 3651384

Title: Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells.

PubMed ID: 3651384

DOI: 10.1021/bi00386a008

PubMed ID: 2920020

Title: Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis.

PubMed ID: 2920020

DOI: 10.1042/bj2570293

PubMed ID: 7680346

Title: Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.

PubMed ID: 7680346

DOI: 10.1016/s0021-9258(18)53497-9

PubMed ID: 3415696

Title: Rat clusterin isolated from primary Sertoli cell-enriched culture medium is sulfated glycoprotein-2 (SGP-2).

PubMed ID: 3415696

DOI: 10.1016/s0006-291x(88)81051-9

PubMed ID: 2299741

Title: Characterization of the products of a gene expressed during androgen-programmed cell death and their potential use as a marker of urogenital injury.

PubMed ID: 2299741

DOI: 10.1016/s0022-5347(17)39975-5

PubMed ID: 16038898

Title: Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells.

PubMed ID: 16038898

DOI: 10.1016/j.yexcr.2005.06.012

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 447
Mass: 51375
Checksum: 9E2FA33E5E0C146E
Sequence:

MKILLLCVAL LLTWDNGMVL GEQEFSDNEL QELSTQGSRY VNKEIQNAVQ GVKHIKTLIE 
KTNAERKSLL NSLEEAKKKK EGALDDTRDS EMKLKAFPEV CNETMMALWE ECKPCLKHTC 
MKFYARVCRS GSGLVGRQLE EFLNQSSPFY FWMNGDRIDS LLESDRQQSQ VLDAMQDSFT 
RASGIIDTLF QDRFFTHEPQ DIHHFSPMGF PHKRPHFLYP KSRLVRSLMP LSHYGPLSFH 
NMFQPFFDMI HQAQQAMDVQ LHSPALQFPD VDFLKEGEDD PTVCKEIRHN STGCLKMKGQ 
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTQQY NELLHSLQSK MLNTSSLLEQ 
LNDQFTWVSQ LANLTQGDDQ YLRVSTVTTH SSDSEVPSRV TEVVVKLFDS DPITVVLPEE 
VSKDNPKFMD TVAEKALQEY RRKSRME

Genular Protein ID: 2722238285

Symbol: A6K6L1_RAT

Name: N/A

UniProtKB Accession Codes:

A6K6L1

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 447
Mass: 51420
Checksum: 607ACC4409ABCFE0
Sequence:

MKILLLCVAL LLTWDNGMVL GEQEFSDNEL QELSTQGSRY VNKEIQNAVQ GVKHIKTLIE 
KTNAERKSLL NSLEEAKKKK EGALDDTRDS EMKLKAFPEV CNETMMALWE ECKPCLKHTC 
MKFYARVCRS GSGLVGRQLE EFLNQSSPFY FWMNGDRIDS LLESDRQQSQ VLDAMQDSFT 
RASGIIDTLF QDRFFTHEPQ DIHHFSPMGF PHKRPHFLYP KSRLVRSLMP LSHYGPLSFH 
NMFQPFFDMI HQAQQAMDVQ LHSPALQFPD VDFLKEGEDD RTVCKEIRHN STGCLKMKGQ 
CEKCQEILSV DCSTNNPAQA NLRQELNDSL QVAERLTQQY NELLHSLQSK MLNTSSLLEQ 
LNDQFSWVSQ LANLTQGDDQ YLRVSTVTTH SSDSEVPSRV TEVVVKLFDS DPITVVLPEE 
VSKDNPKFMD TVAEKALQEY RRKSRME

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Clu

Associated with

Other Information

Biosynthesis and molecular cloning of sulfated glycoprotein 2 secreted by rat Sertoli cells. PubMed ID: 3651384

Identification of an androgen-repressed mRNA in rat ventral prostate as coding for sulphated glycoprotein 2 by cDNA cloning and sequence analysis. PubMed ID: 2920020

Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis. PubMed ID: 7680346

Rat clusterin isolated from primary Sertoli cell-enriched culture medium is sulfated glycoprotein-2 (SGP-2). PubMed ID: 3415696

Characterization of the products of a gene expressed during androgen-programmed cell death and their potential use as a marker of urogenital injury. PubMed ID: 2299741

Clusterin interacts with SCLIP (SCG10-like protein) and promotes neurite outgrowth of PC12 cells. PubMed ID: 16038898

Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues. PubMed ID: 22673903

Gene and alternative splicing annotation with AIR. PubMed ID: 15632090