Genular: Defining Cellular Identity and Function

Details for: Ugt1a1

Gene ID: 24861

Symbol: Ugt1a1

Ensembl ID: ENSRNOG00000018740

Description: UDP glucuronosyltransferase family 1 member A1

Associated with

Aspirin adme
(R-RNO-9749641)
Atorvastatin adme
(R-RNO-9754706)
Biological oxidations
(R-RNO-211859)
Drug adme
(R-RNO-9748784)
Glucuronidation
(R-RNO-156588)
Heme degradation
(R-RNO-189483)
Metabolism
(R-RNO-1430728)
Metabolism of porphyrins
(R-RNO-189445)
Paracetamol adme
(R-RNO-9753281)
Phase ii - conjugation of compounds
(R-RNO-156580)
Prednisone adme
(R-RNO-9757110)
Acute-phase response
(GO:0006953)
Animal organ regeneration
(GO:0031100)
Bilirubin conjugation
(GO:0006789)
Biphenyl catabolic process
(GO:0070980)
Cellular glucuronidation
(GO:0052695)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to ethanol
(GO:0071361)
Cellular response to glucocorticoid stimulus
(GO:0071385)
Cellular response to hormone stimulus
(GO:0032870)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cytochrome complex
(GO:0070069)
Endoplasmic reticulum
(GO:0005783)
Endoplasmic reticulum chaperone complex
(GO:0034663)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
Enzyme inhibitor activity
(GO:0004857)
Estrogen metabolic process
(GO:0008210)
Flavone metabolic process
(GO:0051552)
Flavonoid glucuronidation
(GO:0052696)
Glucuronosyltransferase activity
(GO:0015020)
Liver development
(GO:0001889)
Negative regulation of cellular glucuronidation
(GO:2001030)
Plasma membrane
(GO:0005886)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Response to ethanol
(GO:0045471)
Response to glucocorticoid
(GO:0051384)
Response to lipopolysaccharide
(GO:0032496)
Response to nutrient
(GO:0007584)
Response to organic cyclic compound
(GO:0014070)
Response to organic substance
(GO:0010033)
Response to starvation
(GO:0042594)
Response to steroid hormone
(GO:0048545)
Response to xenobiotic stimulus
(GO:0009410)
Retinoic acid binding
(GO:0001972)
Steroid binding
(GO:0005496)
Xenobiotic glucuronidation
(GO:0052697)

Other Information

Proteins

Genular Protein ID: 1894339452

Symbol: UD11_RAT

Name: B1

UniProtKB Accession Codes:

Q64550 Q64635

Database IDs:

Citations:

PubMed ID: 7603447

Title: Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin.

PubMed ID: 7603447

PubMed ID: 7608130

Title: Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex.

PubMed ID: 7608130

DOI: 10.1093/jb/117.2.392

PubMed ID: 7986077

Title: Purification of a phenobarbital-inducible morphine UDP-glucuronyltransferase isoform, absent from Gunn rat liver.

PubMed ID: 7986077

DOI: 10.1006/abbi.1994.1510

PubMed ID: 8554318

Title: Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies.

PubMed ID: 8554318

DOI: 10.1006/abbi.1995.0039

Sequence Information:

Length: 535
Mass: 59663
Checksum: 26B642FCA7DD4082
Sequence:

MSVVCRSSCS LLLLPCLLLC VLGPSASHAG KLLVIPIDGS HWLSMLGVIQ QLQQKGHEVV 
VIAPEASIHI KEGSFYTMRK YPVPFQNENV TAAFVELGRS VFDQDPFLLR VVKTYNKVKR 
DSSMLLSGCS HLLHNAEFMA SLEQSHFDAL LTDPFLPCGS IVAQYLSLPA VYFLNALPCS 
LDLEATQCPA PLSYVPKSLS SNTDRMNFLQ RVKNMIIALT ENFLCRVVYS PYGSLATEIL 
QKEVTVKDLL SPASIWLMRN DFVKDYPRPI MPNMVFIGGI NCLQKKALSQ EFEAYVNASG 
EHGIVVFSLG SMVSEIPEKK AMEIAEALGR IPQTVLWRYT GTRPSNLAKN TILVKWLPQN 
DLLGHPKARA FITHSGSHGI YEGICNGVPM VMMPLFGDQM DNAKRMETRG AGVTLNVLEM 
TADDLENALK TVINNKSYKE NIMRLSSLHK DRPIEPLDLA VFWVEYVMRH KGAPHLRPAA 
HDLTWYQYHS LDVIGFLLAI VLTVVFIVYK SCAYGCRKCF GGKGRVKKSH KSKTH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ugt1a1

Associated with

Other Information

Cloning and stable expression of a cDNA encoding a rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 1.1) that catalyzes the glucuronidation of opioids and bilirubin. PubMed ID: 7603447

Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex. PubMed ID: 7608130

Purification of a phenobarbital-inducible morphine UDP-glucuronyltransferase isoform, absent from Gunn rat liver. PubMed ID: 7986077

Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isozyme in rat hepatic microsomes using anti-peptide antibodies. PubMed ID: 8554318

Database document:

PubMed ID: 7603447

PubMed ID: 7608130

PubMed ID: 7986077

PubMed ID: 8554318