Genular: Defining Cellular Identity and Function

Details for: Vhl

Gene ID: 24874

Symbol: Vhl

Ensembl ID: ENSRNOG00000010258

Description: von Hippel-Lindau tumor suppressor

Associated with

Adaptive immune system
(R-RNO-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-RNO-983168)
Cellular responses to stimuli
(R-RNO-8953897)
Cellular responses to stress
(R-RNO-2262752)
Cellular response to hypoxia
(R-RNO-1234174)
Class i mhc mediated antigen processing & presentation
(R-RNO-983169)
Immune system
(R-RNO-168256)
Metabolism of proteins
(R-RNO-392499)
Neddylation
(R-RNO-8951664)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-RNO-1234176)
Post-translational protein modification
(R-RNO-597592)
Rhobtb3 atpase cycle
(R-RNO-9706019)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-RNO-9716542)
Signal transduction
(R-RNO-162582)
Sumo e3 ligases sumoylate target proteins
(R-RNO-3108232)
Sumoylation
(R-RNO-2990846)
Sumoylation of ubiquitinylation proteins
(R-RNO-3232142)
Amyloid fibril formation
(GO:1990000)
Angiogenesis
(GO:0001525)
Blood vessel endothelial cell migration
(GO:0043534)
Camera-type eye morphogenesis
(GO:0048593)
Ciliary body morphogenesis
(GO:0061073)
Cilium
(GO:0005929)
Cul2-ring ubiquitin ligase complex
(GO:0031462)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor binding
(GO:0140297)
Endoplasmic reticulum
(GO:0005783)
Endothelial cell differentiation
(GO:0045446)
Enzyme binding
(GO:0019899)
Extracellular matrix organization
(GO:0030198)
Eye pigmentation
(GO:0048069)
Glutamatergic synapse
(GO:0098978)
Homeostasis of number of retina cells
(GO:0048877)
Hypoxia-inducible factor-1alpha signaling pathway
(GO:0097411)
Intracellular non-membrane-bounded organelle
(GO:0043232)
Iris morphogenesis
(GO:0061072)
Melanin metabolic process
(GO:0006582)
Molecular adaptor activity
(GO:0060090)
Negative regulation of autophagy
(GO:0010507)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of endothelial cell differentiation
(GO:0045602)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of hypoxia-inducible factor-1alpha signaling pathway
(GO:1902072)
Negative regulation of receptor signaling pathway via jak-stat
(GO:0046426)
Negative regulation of signal transduction
(GO:0009968)
Negative regulation of thymocyte apoptotic process
(GO:0070244)
Negative regulation of torc1 signaling
(GO:1904262)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of transcription elongation by rna polymerase ii
(GO:0034244)
Neuron differentiation
(GO:0030182)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pancreatic a cell differentiation
(GO:0003310)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Postsynaptic density
(GO:0014069)
Proteasomal protein catabolic process
(GO:0010498)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein transport
(GO:0015031)
Protein ubiquitination
(GO:0016567)
Regulation of apoptotic signaling pathway
(GO:2001233)
Regulation of catecholamine metabolic process
(GO:0042069)
Regulation of cellular response to hypoxia
(GO:1900037)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of postsynapse organization
(GO:0099175)
Regulation of protein localization
(GO:0032880)
Regulation of thymocyte apoptotic process
(GO:0070243)
Regulation protein catabolic process at postsynapse
(GO:0140252)
Response to ethanol
(GO:0045471)
Response to hypoxia
(GO:0001666)
Transcription corepressor activity
(GO:0003714)
Transcription elongation factor activity
(GO:0003711)
Transcription regulator complex
(GO:0005667)
Type b pancreatic cell differentiation
(GO:0003309)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase-substrate adaptor activity
(GO:1990756)
Vcb complex
(GO:0030891)

Other Information

Proteins

von Hippel-Lindau disease tumor suppressor

Genular Protein ID: 3949685990

Symbol: VHL_RAT

Name: von Hippel-Lindau disease tumor suppressor

UniProtKB Accession Codes:

Q64259 Q64197 Q80WY8

Database IDs:

Citations:

PubMed ID: 7604013

Title: Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.

PubMed ID: 7604013

DOI: 10.1073/pnas.92.14.6459

PubMed ID: 7493907

Title: Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas.

PubMed ID: 7493907

DOI: 10.1111/j.1349-7006.1995.tb02999.x

PubMed ID: 8599582

Title: Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.

PubMed ID: 8599582

DOI: 10.1002/(sici)1098-2744(199602)15:2<154::aid-mc8>3.0.co;2-j

PubMed ID: 17936701

Title: pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2.

PubMed ID: 17936701

DOI: 10.1016/j.molcel.2007.09.010

Sequence Information:

Length: 185
Mass: 21215
Checksum: 3AD15FD9EF139E13
Sequence:

MPRKAASPEE AERMPGSEEI EAGRPRPVLR SVNSREPSQV IFCNRSPRVV LPLWLNFDGE 
PQPYPTLPPG TGRRIHSYRG HLWLFRDAGT HDGLLVNQTE LFVPSLNVDG QPIFANITLP 
VYTLKERCLQ VVRSLVKPEN YRRLDIVRSL YEDLEDHPNV RKDIQRLTQE HLENQALGEE 
PEGVH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Vhl

Associated with

Other Information

Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations. PubMed ID: 7604013

Cloning of the rat homologue of the von Hippel-Lindau tumor suppressor gene and its non-somatic mutation in rat renal cell carcinomas. PubMed ID: 7493907

Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus. PubMed ID: 8599582

pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2. PubMed ID: 17936701

Database document:

PubMed ID: 7604013

PubMed ID: 7493907

PubMed ID: 8599582

PubMed ID: 17936701