Genular: Defining Cellular Identity and Function

Details for: Bcl2l1

Gene ID: 24888

Symbol: Bcl2l1

Ensembl ID: ENSRNOG00000007946

Description: Bcl2-like 1

Associated with

Apoptosis
(R-RNO-109581)
Bh3-only proteins associate with and inactivate anti-apoptotic bcl-2 members
(R-RNO-111453)
Immune system
(R-RNO-168256)
Inflammasomes
(R-RNO-622312)
Innate immune system
(R-RNO-168249)
Intrinsic pathway for apoptosis
(R-RNO-109606)
Mapk1/mapk3 signaling
(R-RNO-5684996)
Mapk family signaling cascades
(R-RNO-5683057)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-RNO-168643)
Programmed cell death
(R-RNO-5357801)
Raf/map kinase cascade
(R-RNO-5673001)
Ras processing
(R-RNO-9648002)
Signal transduction
(R-RNO-162582)
The nlrp1 inflammasome
(R-RNO-844455)
Apoptotic process
(GO:0006915)
Apoptotic process in bone marrow cell
(GO:0071839)
Bh3 domain binding
(GO:0051434)
Bh domain binding
(GO:0051400)
Cellular response to alkaloid
(GO:0071312)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to camp
(GO:0071320)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to erythropoietin
(GO:0036018)
Cellular response to gamma radiation
(GO:0071480)
Cellular response to hypoxia
(GO:0071456)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to tumor necrosis factor
(GO:0071356)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cerebral cortex development
(GO:0021987)
Clathrin binding
(GO:0030276)
Cysteine-type endopeptidase inhibitor activity involved in apoptotic process
(GO:0043027)
Dendritic cell apoptotic process
(GO:0097048)
Dendritic cell proliferation
(GO:0044565)
Ectopic germ cell programmed cell death
(GO:0035234)
Endocytosis
(GO:0006897)
Epithelial cell proliferation
(GO:0050673)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Fertilization
(GO:0009566)
Germ cell development
(GO:0007281)
Gonad development
(GO:0008406)
Gtpase binding
(GO:0051020)
Hepatocyte apoptotic process
(GO:0097284)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
In utero embryonic development
(GO:0001701)
Male gonad development
(GO:0008584)
Mdm2/mdm4 family protein binding
(GO:0097371)
Mitochondrion organization
(GO:0007005)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of developmental process
(GO:0051093)
Negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
(GO:1902236)
Negative regulation of execution phase of apoptosis
(GO:1900118)
Negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902042)
Negative regulation of intrinsic apoptotic signaling pathway in response to dna damage
(GO:1902230)
Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
(GO:1901029)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of release of cytochrome c from mitochondria
(GO:0090201)
Neuron apoptotic process
(GO:0051402)
Ovarian follicle development
(GO:0001541)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of mononuclear cell proliferation
(GO:0032946)
Positive regulation of synaptic vesicle endocytosis
(GO:1900244)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Regulation of apoptotic process
(GO:0042981)
Regulation of cytokinesis
(GO:0032465)
Regulation of growth
(GO:0040008)
Regulation of long-term synaptic depression
(GO:1900452)
Regulation of mitochondrial membrane permeability
(GO:0046902)
Regulation of mitochondrial membrane potential
(GO:0051881)
Release of cytochrome c from mitochondria
(GO:0001836)
Response to cycloheximide
(GO:0046898)
Response to cytokine
(GO:0034097)
Response to electrical stimulus
(GO:0051602)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to erythropoietin
(GO:0036017)
Response to hydrogen peroxide
(GO:0042542)
Response to hypoxia
(GO:0001666)
Response to inorganic substance
(GO:0010035)
Response to ischemia
(GO:0002931)
Response to lead ion
(GO:0010288)
Response to lipopolysaccharide
(GO:0032496)
Response to organic cyclic compound
(GO:0014070)
Response to organonitrogen compound
(GO:0010243)
Response to oxidative stress
(GO:0006979)
Response to peptide hormone
(GO:0043434)
Response to radiation
(GO:0009314)
Response to virus
(GO:0009615)
Response to xenobiotic stimulus
(GO:0009410)
Spermatogenesis
(GO:0007283)
Synaptic vesicle recycling via endosome
(GO:0036466)

Other Information

Proteins

Genular Protein ID: 1430490310

Symbol: B2CL1_RAT

Name: Bcl-2-like protein 1

UniProtKB Accession Codes:

P53563 P70613 P70614 Q52KS0 Q62678 Q62836 Q64087 Q64128

Database IDs:

Citations:

PubMed ID: 8662675

Title: An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells.

PubMed ID: 8662675

DOI: 10.1074/jbc.271.22.13258

PubMed ID: 7828536

Title: Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels.

PubMed ID: 7828536

DOI: 10.1210/endo.136.1.7828536

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18250306

Title: Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons.

PubMed ID: 18250306

DOI: 10.1073/pnas.0711647105

PubMed ID: 21926988

Title: Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase.

PubMed ID: 21926988

DOI: 10.1038/ncb2330

PubMed ID: 23792689

Title: A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis.

PubMed ID: 23792689

DOI: 10.1038/ncb2791

PubMed ID: 9346936

Title: Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family.

PubMed ID: 9346936

DOI: 10.1074/jbc.272.44.27886

Sequence Information:

Length: 233
Mass: 26158
Checksum: 2B62B6C63864BC8F
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIASWM ATYLNDHLEP 
WIQENGGWDT FVDLYGNNAA AESRKGQERF NRWFLTGMTV AGVVLLGSLF SRK

Genular Protein ID: 887889139

Symbol: Q7TS62_RAT

Name: N/A

UniProtKB Accession Codes:

Q7TS62 A6KHR6

Database IDs:

Citations:

PubMed ID: 12787069

Title: Bcl-2-related protein family gene expression during oligodendroglial differentiation.

PubMed ID: 12787069

DOI: 10.1046/j.1471-4159.2003.01795.x

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

Length: 284
Mass: 31776
Checksum: B8F35F641D4E029E
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQVVNEL FRDGVNWGRI VAFFSFGGAL CVESVDKEMQ VLVSRIASWM ATYLNDHLEP 
WIQENGGWVR TTPLVCPPLV CLSSVEIPNC PFWSPGMVVE DIDYSGDIPG FTLIPGVNFG 
NIDDPVFKEP VFFILATLVA PQFHSFVPIS RQRKTACVFT WLKT

Genular Protein ID: 1629248966

Symbol: Q548R7_RAT

Name: N/A

UniProtKB Accession Codes:

Q548R7

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 170
Mass: 18987
Checksum: D90868EC7F69ED59
Sequence:

MSQSNRELVV DFLSYKLSQK GYSWSQFSDV EENRTEAPEE TEPERETPSA INGNPSWHLA 
DSPAVNGATG HSSSLDAREV IPMAAVKQAL REAGDEFELR YRRAFSDLTS QLHITPGTAY 
QSFEQDTFVD LYGNNAAAES RKGQERFNRW FLTGMTVAGV VLLGSLFSRK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Bcl2l1

Associated with

Other Information

An additional form of rat Bcl-x, Bcl-xbeta, generated by an unspliced RNA, promotes apoptosis in promyeloid cells. PubMed ID: 8662675

Expression of members of the Bcl-2 gene family in the immature rat ovary: equine chorionic gonadotropin-mediated inhibition of granulosa cell apoptosis is associated with decreased Bax and constitutive Bcl-2 and Bcl-xlong messenger ribonucleic acid levels. PubMed ID: 7828536

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons. PubMed ID: 18250306

Bcl-xL regulates metabolic efficiency of neurons through interaction with the mitochondrial F1FO ATP synthase. PubMed ID: 21926988

A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. PubMed ID: 23792689

Crystal structure of rat Bcl-xL. Implications for the function of the Bcl-2 protein family. PubMed ID: 9346936

Bcl-2-related protein family gene expression during oligodendroglial differentiation. PubMed ID: 12787069

Genome sequence of the Brown Norway rat yields insights into mammalian evolution. PubMed ID: 15057822

Gene and alternative splicing annotation with AIR. PubMed ID: 15632090

Database document:

PubMed ID: 8662675

PubMed ID: 7828536

PubMed ID: 15489334

PubMed ID: 18250306

PubMed ID: 21926988

PubMed ID: 23792689

PubMed ID: 9346936

PubMed ID: 12787069

PubMed ID: 15057822

PubMed ID: 15632090