Genular: Defining Cellular Identity and Function

Details for: Slc6a3

Gene ID: 24898

Symbol: Slc6a3

Ensembl ID: ENSRNOG00000017302

Description: solute carrier family 6 member 3

Associated with

Dopamine clearance from the synaptic cleft
(R-RNO-379401)
Na+/cl- dependent neurotransmitter transporters
(R-RNO-442660)
Neuronal system
(R-RNO-112316)
Neurotransmitter clearance
(R-RNO-112311)
Slc-mediated transmembrane transport
(R-RNO-425407)
Transmission across chemical synapses
(R-RNO-112315)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-RNO-425366)
Transport of small molecules
(R-RNO-382551)
Adenohypophysis development
(GO:0021984)
Amine binding
(GO:0043176)
Amino acid transport
(GO:0006865)
Axon
(GO:0030424)
Axon terminus
(GO:0043679)
Cell surface
(GO:0009986)
Cognition
(GO:0050890)
Dopamine:sodium symporter activity
(GO:0005330)
Dopamine binding
(GO:0035240)
Dopamine biosynthetic process
(GO:0042416)
Dopamine catabolic process
(GO:0042420)
Dopaminergic synapse
(GO:0098691)
Dopamine transport
(GO:0015872)
Dopamine uptake
(GO:0090494)
Dopamine uptake involved in synaptic transmission
(GO:0051583)
Flotillin complex
(GO:0016600)
Heterocyclic compound binding
(GO:1901363)
Hyaloid vascular plexus regression
(GO:1990384)
Lactation
(GO:0007595)
Locomotory behavior
(GO:0007626)
Membrane raft
(GO:0045121)
Metal ion binding
(GO:0046872)
Monoamine transmembrane transporter activity
(GO:0008504)
Monoamine transport
(GO:0015844)
Neuronal cell body
(GO:0043025)
Neuronal cell body membrane
(GO:0032809)
Neuron projection
(GO:0043005)
Neurotransmitter transmembrane transporter activity
(GO:0005326)
Neurotransmitter transport
(GO:0006836)
Neurotransmitter uptake
(GO:0001504)
Norepinephrine:sodium symporter activity
(GO:0005334)
Norepinephrine transport
(GO:0015874)
Norepinephrine uptake
(GO:0051620)
Plasma membrane
(GO:0005886)
Positive regulation of multicellular organism growth
(GO:0040018)
Postsynaptic membrane
(GO:0045211)
Prepulse inhibition
(GO:0060134)
Presynaptic membrane
(GO:0042734)
Protease binding
(GO:0002020)
Protein-containing complex binding
(GO:0044877)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of dopamine metabolic process
(GO:0042053)
Response to camp
(GO:0051591)
Response to cocaine
(GO:0042220)
Response to ethanol
(GO:0045471)
Response to iron ion
(GO:0010039)
Response to nicotine
(GO:0035094)
Response to organic cyclic compound
(GO:0014070)
Response to xenobiotic stimulus
(GO:0009410)
Sensory perception of smell
(GO:0007608)
Signaling receptor binding
(GO:0005102)
Sodium ion transmembrane transport
(GO:0035725)

Other Information

Proteins

Sodium-dependent dopamine transporter

Genular Protein ID: 408772037

Symbol: SC6A3_RAT

Name: Sodium-dependent dopamine transporter

UniProtKB Accession Codes:

P23977

Database IDs:

Citations:

PubMed ID: 1948035

Title: Cloning and expression of a cocaine-sensitive rat dopamine transporter.

PubMed ID: 1948035

DOI: 10.1126/science.1948035

PubMed ID: 1948034

Title: Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA.

PubMed ID: 1948034

DOI: 10.1126/science.1948034

PubMed ID: 1765147

Title: Cloning and functional characterization of a cocaine-sensitive dopamine transporter.

PubMed ID: 1765147

DOI: 10.1016/0014-5793(91)81406-x

PubMed ID: 1502198

Title: Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding.

PubMed ID: 1502198

DOI: 10.1073/pnas.89.16.7782

PubMed ID: 8125921

Title: Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence.

PubMed ID: 8125921

DOI: 10.1016/s0021-9258(17)37256-3

PubMed ID: 32963038

Title: PLRP2 selectively localizes synaptic membrane proteins via acyl-chain remodeling of phospholipids.

PubMed ID: 32963038

DOI: 10.1194/jlr.ra120001087

Sequence Information:

Length: 619
Mass: 68746
Checksum: DF3A30C981095D24
Sequence:

MSKSKCSVGP MSSVVAPAKE SNAVGPREVE LILVKEQNGV QLTNSTLINP PQTPVEAQER 
ETWSKKIDFL LSVIGFAVDL ANVWRFPYLC YKNGGGAFLV PYLLFMVIAG MPLFYMELAL 
GQFNREGAAG VWKICPVLKG VGFTVILISF YVGFFYNVII AWALHYFFSS FTMDLPWIHC 
NNTWNSPNCS DAHASNSSDG LGLNDTFGTT PAAEYFERGV LHLHQSRGID DLGPPRWQLT 
ACLVLVIVLL YFSLWKGVKT SGKVVWITAT MPYVVLTALL LRGVTLPGAM DGIRAYLSVD 
FYRLCEASVW IDAATQVCFS LGVGFGVLIA FSSYNKFTNN CYRDAIITTS INSLTSFSSG 
FVVFSFLGYM AQKHNVPIRD VATDGPGLIF IIYPEAIATL PLSSAWAAVF FLMLLTLGID 
SAMGGMESVI TGLVDEFQLL HRHRELFTLG IVLATFLLSL FCVTNGGIYV FTLLDHFAAG 
TSILFGVLIE AIGVAWFYGV QQFSDDIKQM TGQRPNLYWR LCWKLVSPCF LLYVVVVSIV 
TFRPPHYGAY IFPDWANALG WIIATSSMAM VPIYATYKFC SLPGSFREKL AYAITPEKDH 
QLVDRGEVRQ FTLRHWLLL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc6a3

Associated with

Other Information

Cloning and expression of a cocaine-sensitive rat dopamine transporter. PubMed ID: 1948035

Cloning and expression of a cocaine-sensitive dopamine transporter complementary DNA. PubMed ID: 1948034

Cloning and functional characterization of a cocaine-sensitive dopamine transporter. PubMed ID: 1765147

Dopamine transporter site-directed mutations differentially alter substrate transport and cocaine binding. PubMed ID: 1502198

Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. PubMed ID: 8125921