Genular: Defining Cellular Identity and Function

Details for: Kpnb1

Gene ID: 24917

Symbol: Kpnb1

Ensembl ID: ENSRNOG00000009275

Description: karyopherin subunit beta 1

Associated with

Apoptosis
(R-RNO-109581)
Apoptosis induced dna fragmentation
(R-RNO-140342)
Apoptotic execution phase
(R-RNO-75153)
Assembly of the orc complex at the origin of replication
(R-RNO-68616)
Assembly of the pre-replicative complex
(R-RNO-68867)
Cell cycle
(R-RNO-1640170)
Cell cycle, mitotic
(R-RNO-69278)
Cytokine signaling in immune system
(R-RNO-1280215)
Dna replication
(R-RNO-69306)
Dna replication pre-initiation
(R-RNO-69002)
Immune system
(R-RNO-168256)
Initiation of nuclear envelope (ne) reformation
(R-RNO-2995383)
Innate immune system
(R-RNO-168249)
Interferon alpha/beta signaling
(R-RNO-909733)
Interferon signaling
(R-RNO-913531)
Metabolism
(R-RNO-1430728)
Metabolism of lipids
(R-RNO-556833)
Metabolism of steroids
(R-RNO-8957322)
Mitotic anaphase
(R-RNO-68882)
Mitotic metaphase and anaphase
(R-RNO-2555396)
M phase
(R-RNO-68886)
Neutrophil degranulation
(R-RNO-6798695)
Nuclear envelope (ne) reassembly
(R-RNO-2995410)
Programmed cell death
(R-RNO-5357801)
Regulation of cholesterol biosynthesis by srebp (srebf)
(R-RNO-1655829)
Astral microtubule organization
(GO:0030953)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Endoplasmic reticulum tubular network
(GO:0071782)
Enzyme binding
(GO:0019899)
Establishment of mitotic spindle localization
(GO:0040001)
Hsp90 protein binding
(GO:0051879)
Importin-alpha family protein binding
(GO:0061676)
Kinesin binding
(GO:0019894)
Mitotic chromosome movement towards spindle pole
(GO:0007079)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle assembly
(GO:0090307)
Nls-bearing protein import into nucleus
(GO:0006607)
Nls-dependent protein nuclear import complex
(GO:0042564)
Nuclear envelope
(GO:0005635)
Nuclear import signal receptor activity
(GO:0061608)
Nuclear localization sequence binding
(GO:0008139)
Nuclear membrane
(GO:0031965)
Nuclear pore
(GO:0005643)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Protein-containing complex
(GO:0032991)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein import into nucleus
(GO:0006606)
Ran protein signal transduction
(GO:0031291)
Ribosomal protein import into nucleus
(GO:0006610)
Rna import into nucleus
(GO:0006404)
Small gtpase binding
(GO:0031267)

Other Information

Proteins

Importin subunit beta-1

Genular Protein ID: 2091042289

Symbol: IMB1_RAT

Name: Importin subunit beta-1

UniProtKB Accession Codes:

P52296

Database IDs:

Citations:

PubMed ID: 7878057

Title: Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins.

PubMed ID: 7878057

DOI: 10.1073/pnas.92.5.1769

PubMed ID: 7604027

Title: Mammalian karyopherin alpha 1 beta and alpha 2 beta heterodimers: alpha 1 or alpha 2 subunit binds nuclear localization signal and beta subunit interacts with peptide repeat-containing nucleoporins.

PubMed ID: 7604027

DOI: 10.1073/pnas.92.14.6532

Sequence Information:

Length: 875
Mass: 97124
Checksum: 9CD77A05744014C4
Sequence:

MELITILEKT VSPDRLELEA AQKFLERAAV ENLPTFLVEL SRVLANPGNS QVARVAAGLQ 
IRLLTSKDPD IKAQYQQRWL AIDANARREV KNYVLQTLGT ETYRPSSASQ CVAGIACAEI 
PVSQWPELIP QLVANVTNPN STEHMKESTL EAIGYICQDI DPEQLQDKSN EILTAIIQGM 
RKEEPSNNVK LAATNALLNS LEFTKANFDK ESERHFIMQV VCEATQCPDT RVRVAALQNL 
VKIMSLYYQY METYMGPALF AITIEAMKSD IDEVALQGIE FWSNVCDEEM DLAIEASEAA 
EQGRPPEHTS KFYAKGALQY LVPILTQTLT KQDENDDDDD WNPCKAAGVC LMLLSTCCED 
DIVPHVLPFI KEHIKNPDWR YRDAAVMAFG SILEGPEPNQ LKPLVIQAMP TLIELMKDPS 
VVVRDTTAWT VGRICELLPE AAINDVYLAP LLQCLIEGLS AEPRVASNVC WAFSSLAEAA 
YEAADVADDQ EEPATYCLSS SFELIVQKLL ETTDRPDGHQ NNLRSSAYES LMEIVKNSAK 
DCYPAVQKTT LVIMERLQQV LQMESHIQST SDRIQFNDLQ SLLCATLQNV LWKVQHQDAL 
QISDVVMASL LRMFQSTAGS GGVQEDALMA VSTLVEVLGG EFLKYMEAFK PFLGIGLKNY 
AECQVCLAAV GLVGDLCRAL QSNILPFCDE VMQLLLENLG NENVHRSVKP QILSVFGDIT 
LAIGGEFKKY LEVVLNTLQQ ASQAQVDKSD FDMVDYLNEL RESCLEAYTG IVQGLKGDQE 
NVHPDVMLVQ PRVEFILSFI DHIAGDEDHT DGVVACAAGL IGDLCTAFGK DVLKLVEARP 
MIHELLTEGR RSKTNKAKTL ATWATKELRK LKNQA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.