Details for: Stat5a

Gene ID: 24918

Symbol: Stat5a

Ensembl ID: ENSRNOG00000019496

Description: signal transducer and activator of transcription 5A

Associated with

  • Activated t cell proliferation
    (GO:0050798)
  • B cell differentiation
    (GO:0030183)
  • Cell population proliferation
    (GO:0008283)
  • Cellular response to cytokine stimulus
    (GO:0071345)
  • Cellular response to granulocyte macrophage colony-stimulating factor stimulus
    (GO:0097011)
  • Cellular response to organic cyclic compound
    (GO:0071407)
  • Cytokine-mediated signaling pathway
    (GO:0019221)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Defense response
    (GO:0006952)
  • Development of secondary female sexual characteristics
    (GO:0046543)
  • Development of secondary male sexual characteristics
    (GO:0046544)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription factor binding
    (GO:0140297)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Eosinophil differentiation
    (GO:0030222)
  • Epithelial cell differentiation involved in prostate gland development
    (GO:0060742)
  • Erythrocyte differentiation
    (GO:0030218)
  • Female pregnancy
    (GO:0007565)
  • Gamma-delta t cell differentiation
    (GO:0042492)
  • Growth hormone receptor signaling pathway via jak-stat
    (GO:0060397)
  • Interleukin-2-mediated signaling pathway
    (GO:0038110)
  • Interleukin-3-mediated signaling pathway
    (GO:0038156)
  • Interleukin-4-mediated signaling pathway
    (GO:0035771)
  • Interleukin-5-mediated signaling pathway
    (GO:0038043)
  • Interleukin-9-mediated signaling pathway
    (GO:0038113)
  • Interleukin-15-mediated signaling pathway
    (GO:0035723)
  • Lactation
    (GO:0007595)
  • Lipid storage
    (GO:0019915)
  • Luteinization
    (GO:0001553)
  • Lymphocyte differentiation
    (GO:0030098)
  • Mammary gland development
    (GO:0030879)
  • Mammary gland epithelium development
    (GO:0061180)
  • Mammary gland involution
    (GO:0060056)
  • Mast cell apoptotic process
    (GO:0033024)
  • Mast cell differentiation
    (GO:0060374)
  • Mast cell proliferation
    (GO:0070662)
  • Mitotic cell cycle
    (GO:0000278)
  • Multicellular organismal reproductive process
    (GO:0048609)
  • Myeloid cell apoptotic process
    (GO:0033028)
  • Natural killer cell differentiation
    (GO:0001779)
  • Natural killer cell mediated cytotoxicity
    (GO:0042267)
  • Negative regulation of erythrocyte differentiation
    (GO:0045647)
  • Negative regulation of mast cell apoptotic process
    (GO:0033026)
  • Negative regulation of myeloid cell apoptotic process
    (GO:0033033)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Peyer's patch development
    (GO:0048541)
  • Phosphate ion binding
    (GO:0042301)
  • Positive regulation of activated t cell proliferation
    (GO:0042104)
  • Positive regulation of b cell differentiation
    (GO:0045579)
  • Positive regulation of blood vessel endothelial cell migration
    (GO:0043536)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of endothelial cell proliferation
    (GO:0001938)
  • Positive regulation of gamma-delta t cell differentiation
    (GO:0045588)
  • Positive regulation of inflammatory response
    (GO:0050729)
  • Positive regulation of interleukin-2 production
    (GO:0032743)
  • Positive regulation of lymphocyte differentiation
    (GO:0045621)
  • Positive regulation of mast cell differentiation
    (GO:0060376)
  • Positive regulation of mast cell proliferation
    (GO:0070668)
  • Positive regulation of mitotic cell cycle
    (GO:0045931)
  • Positive regulation of multicellular organism growth
    (GO:0040018)
  • Positive regulation of natural killer cell differentiation
    (GO:0032825)
  • Positive regulation of natural killer cell mediated cytotoxicity
    (GO:0045954)
  • Positive regulation of t cell proliferation
    (GO:0042102)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Prostate gland epithelium morphogenesis
    (GO:0060740)
  • Protein binding
    (GO:0005515)
  • Receptor signaling pathway via jak-stat
    (GO:0007259)
  • Reelin-mediated signaling pathway
    (GO:0038026)
  • Regulation of cell adhesion
    (GO:0030155)
  • Regulation of cell population proliferation
    (GO:0042127)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of epithelial cell differentiation
    (GO:0030856)
  • Regulation of multicellular organism growth
    (GO:0040014)
  • Regulation of steroid metabolic process
    (GO:0019218)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to ethanol
    (GO:0045471)
  • Response to nutrient levels
    (GO:0031667)
  • Response to organic substance
    (GO:0010033)
  • Response to peptide hormone
    (GO:0043434)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Signal transduction
    (GO:0007165)
  • Taurine metabolic process
    (GO:0019530)
  • T cell differentiation in thymus
    (GO:0033077)
  • T cell homeostasis
    (GO:0043029)
  • T cell proliferation
    (GO:0042098)
  • Transcription by rna polymerase ii
    (GO:0006366)

Other Information

Genular Protein ID: 382558397

Symbol: STA5A_RAT

Name: Signal transducer and activator of transcription 5A

UniProtKB Accession Codes:

Q62771

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID 1 CDD 3 CTD 1 EMBL 1 GO 88 Gene3D 5 GlyGen 1 InParanoid 1 InterPro 13 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 5 PhosphoSitePlus 1 Proteomes 1 RGD 1 Reactome 9 RefSeq 1 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 4 UCSC 1 UniProtKB 3 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8584036

Title: Regulation of mammary gland factor/Stat5a during mammary gland development.

PubMed ID: 8584036

DOI: 10.1210/mend.9.11.8584036

PubMed ID: 19088846

Title: Analysis of STAT1 activation by six FGFR3 mutants associated with skeletal dysplasia undermines dominant role of STAT1 in FGFR3 signaling in cartilage.

PubMed ID: 19088846

DOI: 10.1371/journal.pone.0003961

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 793
  • Mass: 90833
  • Checksum: C0C34EE3F5879FB5
  • Sequence:
    • MAGWIQAQQL QGDALRQMQV LYGQHFPIEV RHYLAQWIES QPWDAIDLDN PQDRGQATQL 
LEGLVQELQK KAEHQVGEDG FVLKIKLGHY ATQLQNTYDR CPMELVRCIR HILYNEQRLV 
REANNCSSPA GVLVDAMSQK HLQINQTFEE LRLITQDTES ELKKLQQTQE YFIIQYQESL 
RIQAQFGQLA QLNPQERMSR ETALQQKQVS LETWLQREAQ TLQQYRVELV EKHQKTLQLL 
RKQQTIILDD ELIQWKRGQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA TVRLLVGGKL 
NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC CVMEYHQATG TLSAHFRNMS 
LKRIKRADRR GAESVTEEKF TVLFESQFSV GSNELVFQVK TLSLPVVVIV HGSQDHNATA 
TVLWDNAFAE PGRVPFAVPD KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNR 
RSNHLEDYNS MSVSWSQFNR ENLPGWNYTF WQWFDGVMEV LKKHHKPHWN DGAILGFVNK 
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSPDRNL WNLKPFTTRD FSIRSLADRL 
GDLNYLIYVF PDRPKDEVFA KYYTPVLAKA VDGYVKPQIK QVVPEFVNAS ADAGANATYM 
DQAPSPVVCP QAHYNMYPPN PDPVLDQDGE FDLDETMDVA RHVEELLRRP MDSLDPRLSP 
PAGLFTSARS SLS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.