Genular: Defining Cellular Identity and Function

Details for: Ptn

Gene ID: 24924

Symbol: Ptn

Ensembl ID: ENSRNOG00000011946

Description: pleiotrophin

Associated with

Mdk and ptn in alk signaling
(R-RNO-9851151)
Signaling by alk
(R-RNO-201556)
Signaling by receptor tyrosine kinases
(R-RNO-9006934)
Signal transduction
(R-RNO-162582)
Basement membrane
(GO:0005604)
Bone mineralization
(GO:0030282)
Carbohydrate binding
(GO:0030246)
Cellular response to hypoxia
(GO:0071456)
Cellular response to organic cyclic compound
(GO:0071407)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Cellular response to uv
(GO:0034644)
Cellular response to vitamin d
(GO:0071305)
Cerebellum development
(GO:0021549)
Chondroitin sulfate binding
(GO:0035374)
Chondroitin sulfate proteoglycan binding
(GO:0035373)
Decidualization
(GO:0046697)
Dendrite arborization
(GO:0140059)
Dendrite regeneration
(GO:0031104)
Endoplasmic reticulum
(GO:0005783)
Endothelial cell differentiation
(GO:0045446)
Estrous cycle
(GO:0044849)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Glycosaminoglycan binding
(GO:0005539)
Growth factor activity
(GO:0008083)
Heart development
(GO:0007507)
Heparan sulfate binding
(GO:1904399)
Heparin binding
(GO:0008201)
Hindbrain development
(GO:0030902)
Integrin-mediated signaling pathway
(GO:0007229)
Integrin binding
(GO:0005178)
Learning
(GO:0007612)
Leukocyte chemotaxis involved in inflammatory response
(GO:0002232)
Liver development
(GO:0001889)
Long-term synaptic potentiation
(GO:0060291)
Lung development
(GO:0030324)
Memory
(GO:0007613)
Modulation of chemical synaptic transmission
(GO:0050804)
Molecular function activator activity
(GO:0140677)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of glial cell proliferation
(GO:0060253)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Negative regulation of membrane potential
(GO:0045837)
Negative regulation of mesenchymal cell proliferation
(GO:0072201)
Negative regulation of neuroblast proliferation
(GO:0007406)
Negative regulation of neuromuscular junction development
(GO:1904397)
Oogenesis
(GO:0048477)
Ossification
(GO:0001503)
Ossification involved in bone remodeling
(GO:0043932)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of axon regeneration
(GO:0048680)
Positive regulation of bone mineralization
(GO:0030501)
Positive regulation of cell-substrate adhesion
(GO:0010811)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dendrite development
(GO:1900006)
Positive regulation of hepatocyte proliferation
(GO:2000347)
Positive regulation of leukocyte chemotaxis
(GO:0002690)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of oligodendrocyte differentiation
(GO:0048714)
Positive regulation of ossification
(GO:0045778)
Positive regulation of skeletal muscle acetylcholine-gated channel clustering
(GO:1904395)
Positive regulation of stem cell differentiation
(GO:2000738)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase inhibitor activity
(GO:0004864)
Proteoglycan binding
(GO:0043394)
Receptor clustering
(GO:0043113)
Regulation of cell shape
(GO:0008360)
Regulation of endothelial cell migration
(GO:0010594)
Regulation of hemopoiesis
(GO:1903706)
Regulation of myelination
(GO:0031641)
Regulation of stem cell population maintenance
(GO:2000036)
Regulation of synaptic plasticity
(GO:0048167)
Response to activity
(GO:0014823)
Response to auditory stimulus
(GO:0010996)
Response to ciliary neurotrophic factor
(GO:1904391)
Response to estradiol
(GO:0032355)
Response to kainic acid
(GO:1904373)
Response to nerve growth factor
(GO:1990089)
Response to progesterone
(GO:0032570)
Response to xenobiotic stimulus
(GO:0009410)
Retina development in camera-type eye
(GO:0060041)
Retinal rod cell differentiation
(GO:0060221)
Rod bipolar cell differentiation
(GO:1904389)
Spinal cord development
(GO:0021510)
Syndecan binding
(GO:0045545)
Thalamus development
(GO:0021794)
Tissue regeneration
(GO:0042246)
Vascular endothelial growth factor binding
(GO:0038085)

Other Information

Proteins

PTN_RAT
A6IEP7_RAT

Genular Protein ID: 4050332254

Symbol: PTN_RAT

Name: N/A

UniProtKB Accession Codes:

P63090 P20935

Database IDs:

Citations:

PubMed ID: 2170351

Title: Molecular cloning of the 18-kDa growth-associated protein of developing brain.

PubMed ID: 2170351

DOI: 10.1016/s0021-9258(17)44817-4

PubMed ID: 2270483

Title: Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity.

PubMed ID: 2270483

DOI: 10.1126/science.2270483

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2388713

Title: Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homology.

PubMed ID: 2388713

DOI: 10.1007/bf00969930

PubMed ID: 1700712

Title: Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteins.

PubMed ID: 1700712

DOI: 10.1016/0006-291x(90)90753-a

PubMed ID: 1768439

Title: Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins.

PubMed ID: 1768439

DOI: 10.3109/08977199109000275

PubMed ID: 8175719

Title: Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3).

PubMed ID: 8175719

DOI: 10.1016/s0021-9258(18)99975-8

PubMed ID: 9817766

Title: Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM).

PubMed ID: 9817766

DOI: 10.1083/jcb.143.4.1113

PubMed ID: 16814777

Title: Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization.

PubMed ID: 16814777

DOI: 10.1016/j.febslet.2006.06.041

PubMed ID: 27671118

Title: HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix.

PubMed ID: 27671118

DOI: 10.1038/srep33916

Sequence Information:

Length: 168
Mass: 18869
Checksum: 2127DA167D2DD33D
Sequence:

MSSQQYQQQR RKFAAAFLAL IFILAAVDTA EAGKKEKPEK KVKKSDCGEW QWSVCVPTSG 
DCGLGTREGT RTGAECKQTM KTQRCKIPCN WKKQFGAECK YQFQAWGECD LNTALKTRTG 
SLKRALHNAD CQKTVTISKP CGKLTKPKPQ AESKKKKKEG KKQEKMLD

Genular Protein ID: 2935572316

Symbol: A6IEP7_RAT

Name: N/A

UniProtKB Accession Codes:

A6IEP7

Database IDs:

Citations:

PubMed ID: 15632090

Title: Gene and alternative splicing annotation with AIR.

PubMed ID: 15632090

DOI: 10.1101/gr.2889405

Sequence Information:

Length: 183
Mass: 20666
Checksum: 7E61B945EAEE011B
Sequence:

MTFTRSGSWL ICRKEMSSQQ YQQQRRKFAA AFLALIFILA AVDTAEAGKK EKPEKKVKKS 
DCGEWQWSVC VPTSGDCGLG TREGTRTGAE CKQTMKTQRC KIPCNWKKQF GAECKYQFQA 
WGECDLNTAL KTRTGSLKRA LHNADCQKTV TISKPCGKLT KPKPQAESKK KKKEGKKQEK 
MLD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ptn

Associated with

Other Information

Molecular cloning of the 18-kDa growth-associated protein of developing brain. PubMed ID: 2170351

Cloning and expression of a developmentally regulated protein that induces mitogenic and neurite outgrowth activity. PubMed ID: 2270483

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Amino-terminal sequences of a novel heparin-binding protein from human, bovine, rat, and chick brain: high interspecies homology. PubMed ID: 2388713

Heparin-binding neurotrophic factor (HBNF) and MK, members of a new family of homologous, developmentally regulated proteins. PubMed ID: 1700712

Cloning, characterization and developmental regulation of two members of a novel human gene family of neurite outgrowth-promoting proteins. PubMed ID: 1768439

Isolation of a neuronal cell surface receptor of heparin binding growth-associated molecule (HB-GAM). Identification as N-syndecan (syndecan-3). PubMed ID: 8175719

Osteoblast recruitment and bone formation enhanced by cell matrix-associated heparin-binding growth-associated molecule (HB-GAM). PubMed ID: 9817766

Protein tyrosine phosphatase receptor type Z is inactivated by ligand-induced oligomerization. PubMed ID: 16814777

HB-GAM (pleiotrophin) reverses inhibition of neural regeneration by the CNS extracellular matrix. PubMed ID: 27671118

Gene and alternative splicing annotation with AIR. PubMed ID: 15632090