Details for: Adrb1

Gene ID: 24925

Symbol: Adrb1

Ensembl ID: ENSRNOG00000017002

Description: adrenoceptor beta 1

Associated with

  • Adrenoceptors
    (R-RNO-390696)
  • Amine ligand-binding receptors
    (R-RNO-375280)
  • Class a/1 (rhodopsin-like receptors)
    (R-RNO-373076)
  • Gpcr ligand binding
    (R-RNO-500792)
  • Signaling by gpcr
    (R-RNO-372790)
  • Signal transduction
    (R-RNO-162582)
  • Adenylate cyclase-activating adrenergic receptor signaling pathway
    (GO:0071880)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Alpha-2a adrenergic receptor binding
    (GO:0031694)
  • Amine binding
    (GO:0043176)
  • Beta1-adrenergic receptor activity
    (GO:0004940)
  • Brown fat cell differentiation
    (GO:0050873)
  • Diet induced thermogenesis
    (GO:0002024)
  • Early endosome
    (GO:0005769)
  • Fear response
    (GO:0042596)
  • Glycogen catabolic process
    (GO:0005980)
  • G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
    (GO:0099579)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Heat generation
    (GO:0031649)
  • Inhibitory postsynaptic potential
    (GO:0060080)
  • Lipid homeostasis
    (GO:0055088)
  • Membrane
    (GO:0016020)
  • Memory
    (GO:0007613)
  • Negative regulation of multicellular organism growth
    (GO:0040015)
  • Negative regulation of smooth muscle contraction
    (GO:0045986)
  • Negative regulation of urine volume
    (GO:0035811)
  • Neuronal dense core vesicle
    (GO:0098992)
  • Norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure
    (GO:0002025)
  • Pdz domain binding
    (GO:0030165)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0106071)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of calcium ion import across plasma membrane
    (GO:1905665)
  • Positive regulation of cell growth involved in cardiac muscle cell development
    (GO:0061051)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of heart rate
    (GO:0010460)
  • Positive regulation of heart rate by epinephrine-norepinephrine
    (GO:0001996)
  • Positive regulation of long-term synaptic potentiation
    (GO:1900273)
  • Positive regulation of systemic arterial blood pressure
    (GO:0003084)
  • Positive regulation of the force of heart contraction by epinephrine-norepinephrine
    (GO:0001997)
  • Positive regulation of the force of heart contraction by norepinephrine
    (GO:0003061)
  • Postsynapse
    (GO:0098794)
  • Protein binding
    (GO:0005515)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein localization to organelle
    (GO:0033365)
  • Regulation of calcium ion transport
    (GO:0051924)
  • Regulation of cardiac muscle cell contraction
    (GO:0086004)
  • Regulation of circadian sleep/wake cycle, sleep
    (GO:0045187)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Response to cold
    (GO:0009409)
  • Rho protein signal transduction
    (GO:0007266)
  • Schaffer collateral - ca1 synapse
    (GO:0098685)

Other Information

Genular Protein ID: 1854794650

Symbol: ADRB1_RAT

Name: Beta-1 adrenergic receptor

UniProtKB Accession Codes:

P18090

Database IDs:

AGR 1 AlphaFoldDB 1 BindingDB 1 CDD 1 CTD 1 ChEMBL 1 DIP 1 DrugCentral 1 EMBL 2 GO 45 Gene3D 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 2 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 1695899

Title: Molecular cloning and expression of the rat beta 1-adrenergic receptor gene.

PubMed ID: 1695899

DOI: 10.1016/s0021-9258(19)38253-5

PubMed ID: 2167473

Title: Primary structure of the rat beta-1 adrenergic receptor gene.

PubMed ID: 2167473

DOI: 10.1093/nar/18.15.4591

PubMed ID: 12391161

Title: Direct binding of the beta1 adrenergic receptor to the cyclic AMP-dependent guanine nucleotide exchange factor CNrasGEF leads to Ras activation.

PubMed ID: 12391161

DOI: 10.1128/mcb.22.22.7942-7952.2002

PubMed ID: 16316992

Title: Proteomic analysis of beta1-adrenergic receptor interactions with PDZ scaffold proteins.

PubMed ID: 16316992

DOI: 10.1074/jbc.m509503200

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 466
  • Mass: 50472
  • Checksum: 2955CB024944A12B
  • Sequence:
    • MGAGALALGA SEPCNLSSAA PLPDGAATAA RLLVLASPPA SLLPPASEGS APLSQQWTAG 
MGLLLALIVL LIVVGNVLVI VAIAKTPRLQ TLTNLFIMSL ASADLVMGLL VVPFGATIVV 
WGRWEYGSFF CELWTSVDVL CVTASIETLC VIALDRYLAI TLPFRYQSLL TRARARALVC 
TVWAISALVS FLPILMHWWR AESDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM 
AFVYLRVFRE AQKQVKKIDS CERRFLTGPP RPPSPAPSPS PGPPRPADSL ANGRSSKRRP 
SRLVALREQK ALKTLGIIMG VFTLCWLPFF LANVVKAFHR DLVPDRLFVF FNWLGYANSA 
FNPIIYCRSP DFRKAFQRLL CCARRAACRR RAAHGDRPRA SGCLARAGPP PSPGAPSDDD 
DDDAGATPPA RLLEPWAGCN GGTTTVDSDS SLDEPGRQGF SSESKV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.