Details for: Ptger3

Gene ID: 24929

Symbol: Ptger3

Ensembl ID: ENSRNOG00000010325

Description: prostaglandin E receptor 3

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-RNO-373076)
  • Eicosanoid ligand-binding receptors
    (R-RNO-391903)
  • G alpha (i) signalling events
    (R-RNO-418594)
  • Gpcr downstream signalling
    (R-RNO-388396)
  • Gpcr ligand binding
    (R-RNO-500792)
  • Prostanoid ligand receptors
    (R-RNO-391908)
  • Signaling by gpcr
    (R-RNO-372790)
  • Signal transduction
    (R-RNO-162582)
  • Adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0007189)
  • Adenylate cyclase-modulating g protein-coupled receptor signaling pathway
    (GO:0007188)
  • Bicarbonate transport
    (GO:0015701)
  • Brush border membrane
    (GO:0031526)
  • Cell surface
    (GO:0009986)
  • Cellular response to forskolin
    (GO:1904322)
  • Cellular response to interleukin-1
    (GO:0071347)
  • Cellular response to lipopolysaccharide
    (GO:0071222)
  • Desensitization of g protein-coupled receptor signaling pathway
    (GO:0002029)
  • Female pregnancy
    (GO:0007565)
  • Fever generation
    (GO:0001660)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Inflammatory response
    (GO:0006954)
  • Intestine smooth muscle contraction
    (GO:0014827)
  • Maternal process involved in parturition
    (GO:0060137)
  • Negative regulation of adenylate cyclase-activating g protein-coupled receptor signaling pathway
    (GO:0106072)
  • Negative regulation of calcium ion transmembrane transport
    (GO:1903170)
  • Negative regulation of circadian sleep/wake cycle, wakefulness
    (GO:1904326)
  • Negative regulation of forebrain neuron differentiation
    (GO:2000978)
  • Negative regulation of gastric acid secretion
    (GO:0060455)
  • Negative regulation of gastrin-induced gastric acid secretion
    (GO:1903640)
  • Negative regulation of insulin secretion
    (GO:0046676)
  • Negative regulation of norepinephrine secretion
    (GO:0010700)
  • Negative regulation of potassium ion transmembrane transport
    (GO:1901380)
  • Neuronal cell body
    (GO:0043025)
  • Nuclear membrane
    (GO:0031965)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of camp-mediated signaling
    (GO:0043950)
  • Positive regulation of circadian sleep/wake cycle, non-rem sleep
    (GO:0046010)
  • Positive regulation of colon smooth muscle contraction
    (GO:1904343)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of fever generation
    (GO:0031622)
  • Positive regulation of gastric mucosal blood circulation
    (GO:1904346)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of inhibitory g protein-coupled receptor phosphorylation
    (GO:1904325)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of myofibroblast contraction
    (GO:1904330)
  • Positive regulation of neutrophil extravasation
    (GO:2000391)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of smooth muscle contraction involved in micturition
    (GO:1904320)
  • Positive regulation of urine volume
    (GO:0035810)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Prostaglandin e receptor activity
    (GO:0004957)
  • Prostaglandin receptor internalization
    (GO:1990767)
  • Proximal neuron projection
    (GO:1990769)
  • Receptor internalization
    (GO:0031623)
  • Regulation of circadian sleep/wake cycle, wakefulness
    (GO:0010840)
  • Regulation of norepinephrine secretion
    (GO:0014061)
  • Response to estradiol
    (GO:0032355)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to progesterone
    (GO:0032570)
  • Response to salt
    (GO:1902074)
  • Response to xenobiotic stimulus
    (GO:0009410)
  • Urinary bladder smooth muscle contraction
    (GO:0014832)

Other Information

Genular Protein ID: 217992041

Symbol: PE2R3_RAT

Name: Prostaglandin E2 receptor EP3 subtype

UniProtKB Accession Codes:

P34980 Q63194 Q64376

Database IDs:

AGR 1 AlphaFoldDB 1 BindingDB 1 CTD 1 ChEMBL 1 DNASU 1 DrugCentral 1 EMBL 5 GO 53 Gene3D 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 InParanoid 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 3 PRINTS 5 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RGD 1 Reactome 2 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 UniProtKB 1 eggNOG 1

Citations:

PubMed ID: 8393672

Title: Molecular cloning and intrarenal localization of rat prostaglandin E2 receptor EP3 subtype.

PubMed ID: 8393672

DOI: 10.1006/bbrc.1993.1904

PubMed ID: 8135830

Title: Two isoforms of the rat kidney EP3 receptor derived by alternative RNA splicing: intrarenal expression co-localization.

PubMed ID: 8135830

DOI: 10.1006/bbrc.1994.1304

PubMed ID: 8076679

Title: Molecular cloning and expression of a prostaglandin E2 receptor of the EP3 beta subtype from rat hepatocytes.

PubMed ID: 8076679

DOI: 10.1016/0014-5793(94)00837-x

PubMed ID: 8919306

Title: Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures.

PubMed ID: 8919306

DOI: 10.1016/0006-8993(95)01256-7

PubMed ID: 11006128

Title: Receptor isoform-specific interaction of prostaglandin EP3 receptor with muskelin.

PubMed ID: 11006128

DOI: 10.1006/bbrc.2000.3467

Sequence Information:

  • Length: 365
  • Mass: 39942
  • Checksum: 3247190CF95FD825
  • Sequence:
    • MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV VRSYRRRESK 
RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL DPSGRLCTFF GLTMTVFGLS 
SLLVASAMAV ERALAIRAPH WYASHMKTRA TPVLLGVWLS VLAFALLPVL GVGRYSVQWP 
GTWCFISTGP AGNETDSARE PGSVAFASAF ACLGLLALVV TFACNLATIK ALVSRCRAKA 
AASQSSAQWG RITTETAIQL MGIMCVLSVC WSPLLIMMLK MIFNQMSVEQ CKTQMGKEKE 
CNSFLIAVRL ASLNQILDPW VYLLLRKILL RKFCQIRDHT NYASSSTSLP CPGSSVLMWS 
DQLER

Genular Protein ID: 441261861

Symbol: G3V7D9_RAT

Name: N/A

UniProtKB Accession Codes:

G3V7D9

Database IDs:

ARBA 8 AlphaFoldDB 1 Bgee 1 CTD 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 InterPro 6 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 5 PROSITE 1 Pfam 1 Proteomes 2 RGD 2 RefSeq 1 SMR 1 SUPFAM 1 TreeFam 1

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 362
  • Mass: 39629
  • Checksum: 698AE64C0D78F939
  • Sequence:
    • MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV SRSYRRRESK 
RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL DPSGRLCTFF GLTMTVFGLS 
SLLVASAMAV ERALAIRAPH WYASHMKTRA TRAVLLGVWL SVLAFALLPV LGVGRYSVQW 
PGTWCFISTG PAGNETDSAR EPGSVAFASA FACLGLLALV VTFACNLATI KALVSRCRAK 
AAASQSSAQW GRITTETAIQ LMGIMCVLSV CWSPLLIMML KMIFNQMSVE QCKTQMGKEK 
ECNSFLIAVR LASLNQILDP WVYLLLRKIL LRKFCQMMNN LKRSFIAIPA SLSMRISSPR 
EG

Genular Protein ID: 978681770

Symbol: A0A0G2JSK4_RAT

Name: N/A

UniProtKB Accession Codes:

A0A0G2JSK4

Database IDs:

ARBA 8 AlphaFoldDB 1 Bgee 1 CTD 1 DNASU 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 InterPro 6 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 5 PROSITE 1 Pfam 1 Proteomes 2 RGD 2 RefSeq 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 15057822

Title: Genome sequence of the Brown Norway rat yields insights into mammalian evolution.

PubMed ID: 15057822

DOI: 10.1038/nature02426

Sequence Information:

  • Length: 366
  • Mass: 40060
  • Checksum: 3D1DD5725F9B5224
  • Sequence:
    • MAGVWAPEHS VEAHSNQSSA ADGCGSVSVA FPITMMVTGF VGNALAMLLV SRSYRRRESK 
RKKSFLLCIG WLALTDLVGQ LLTSPVVILV YLSQRRWEQL DPSGRLCTFF GLTMTVFGLS 
SLLVASAMAV ERALAIRAPH WYASHMKTRA TRAVLLGVWL SVLAFALLPV LGVGRYSVQW 
PGTWCFISTG PAGNETDSAR EPGSVAFASA FACLGLLALV VTFACNLATI KALVSRCRAK 
AAASQSSAQW GRITTETAIQ LMGIMCVLSV CWSPLLIMML KMIFNQMSVE QCKTQMGKEK 
ECNSFLIAVR LASLNQILDP WVYLLLRKIL LRKFCQIRDH TNYASSSTSL PCPGSSVLMW 
SDQLER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.