Genular: Defining Cellular Identity and Function

Details for: Cd4

Gene ID: 24932

Symbol: Cd4

Ensembl ID: ENSRNOG00000071219

Description: Cd4 molecule

Associated with

Adaptive immune system
(R-RNO-1280218)
Alpha-defensins
(R-RNO-1462054)
Antimicrobial peptides
(R-RNO-6803157)
Cargo recognition for clathrin-mediated endocytosis
(R-RNO-8856825)
Clathrin-mediated endocytosis
(R-RNO-8856828)
Costimulation by the cd28 family
(R-RNO-388841)
Cytokine signaling in immune system
(R-RNO-1280215)
Defensins
(R-RNO-1461973)
Downstream tcr signaling
(R-RNO-202424)
Generation of second messenger molecules
(R-RNO-202433)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Membrane trafficking
(R-RNO-199991)
Other interleukin signaling
(R-RNO-449836)
Pd-1 signaling
(R-RNO-389948)
Phosphorylation of cd3 and tcr zeta chains
(R-RNO-202427)
Signaling by interleukins
(R-RNO-449147)
Tcr signaling
(R-RNO-202403)
Translocation of zap-70 to immunological synapse
(R-RNO-202430)
Vesicle-mediated transport
(R-RNO-5653656)
Adaptive immune response
(GO:0002250)
Calcium-mediated signaling
(GO:0019722)
Cell adhesion
(GO:0007155)
Cell surface
(GO:0009986)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to granulocyte macrophage colony-stimulating factor stimulus
(GO:0097011)
Coreceptor activity
(GO:0015026)
Defense response to gram-negative bacterium
(GO:0050829)
Endoplasmic reticulum lumen
(GO:0005788)
Endoplasmic reticulum membrane
(GO:0005789)
Enzyme binding
(GO:0019899)
External side of plasma membrane
(GO:0009897)
Helper t cell enhancement of adaptive immune response
(GO:0035397)
Identical protein binding
(GO:0042802)
Immunoglobulin binding
(GO:0019865)
Interleukin-15-mediated signaling pathway
(GO:0035723)
Interleukin-16 binding
(GO:0042011)
Interleukin-16 receptor activity
(GO:0042012)
Lipid binding
(GO:0008289)
Macrophage differentiation
(GO:0030225)
Maintenance of protein location in cell
(GO:0032507)
Membrane raft
(GO:0045121)
Mhc class ii protein binding
(GO:0042289)
Mhc class ii protein complex binding
(GO:0023026)
Plasma membrane
(GO:0005886)
Positive regulation of calcium-mediated signaling
(GO:0050850)
Positive regulation of calcium ion transport into cytosol
(GO:0010524)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of monocyte differentiation
(GO:0045657)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of t cell activation
(GO:0050870)
Positive regulation of t cell proliferation
(GO:0042102)
Positive regulation of viral entry into host cell
(GO:0046598)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of calcium ion transport
(GO:0051924)
Regulation of t cell activation
(GO:0050863)
Response to estradiol
(GO:0032355)
Response to vitamin d
(GO:0033280)
Signaling receptor binding
(GO:0005102)
T cell activation
(GO:0042110)
T cell differentiation
(GO:0030217)
T cell selection
(GO:0045058)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

T-cell surface glycoprotein CD4

Genular Protein ID: 4267870141

Symbol: CD4_RAT

Name: T-cell surface glycoprotein CD4

UniProtKB Accession Codes:

P05540

Database IDs:

Citations:

PubMed ID: 3104900

Title: Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains.

PubMed ID: 3104900

DOI: 10.1073/pnas.84.6.1649

PubMed ID: 2113054

Title: High level expression in Chinese hamster ovary cells of soluble forms of CD4 T lymphocyte glycoprotein including glycosylation variants.

PubMed ID: 2113054

DOI: 10.1016/s0021-9258(18)86961-7

PubMed ID: 8493535

Title: Crystal structure of domains 3 and 4 of rat CD4: relation to the NH2-terminal domains.

PubMed ID: 8493535

DOI: 10.1126/science.8493535

Sequence Information:

Length: 457
Mass: 51438
Checksum: 477BE157D30954C1
Sequence:

MCRGFSFRHL LPLLLLQLSK LLVVTQGKTV VLGKEGGSAE LPCESTSRRS ASFAWKSSDQ 
KTILGYKNKL LIKGSLELYS RFDSRKNAWE RGSFPLIINK LRMEDSQTYV CELENKKEEV 
ELWVFRVTFN PGTRLLQGQS LTLILDSNPK VSDPPIECKH KSSNIVKDSK AFSTHSLRIQ 
DSGIWNCTVT LNQKKHSFDM KLSVLGFAST SITAYKSEGE SAEFSFPLNL GEESLQGELR 
WKAEKAPSSQ SWITFSLKNQ KVSVQKSTSN PKFQLSETLP LTLQIPQVSL QFAGSGNLTL 
TLDRGILYQE VNLVVMKVTQ PDSNTLTCEV MGPTSPKMRL ILKQENQEAR VSRQEKVIQV 
QAPEAGVWQC LLSEGEEVKM DSKIQVLSKG LNQTMFLAVV LGSAFSFLVF TGLCILFCVR 
CRHQQRQAAR MSQIKRLLSE KKTCQCSHRM QKSHNLI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.