Genular: Defining Cellular Identity and Function

Details for: Atp7a

Gene ID: 24941

Symbol: Atp7a

Ensembl ID: ENSRNOG00000061367

Description: ATPase copper transporting alpha

Associated with

Antimicrobial peptides
(R-RNO-6803157)
Immune system
(R-RNO-168256)
Innate immune system
(R-RNO-168249)
Ion channel transport
(R-RNO-983712)
Ion influx/efflux at host-pathogen interface
(R-RNO-6803544)
Ion transport by p-type atpases
(R-RNO-936837)
Transport of small molecules
(R-RNO-382551)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Atp metabolic process
(GO:0046034)
Blood vessel development
(GO:0001568)
Blood vessel remodeling
(GO:0001974)
Cartilage development
(GO:0051216)
Catecholamine metabolic process
(GO:0006584)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to antibiotic
(GO:0071236)
Cellular response to cadmium ion
(GO:0071276)
Cellular response to cobalt ion
(GO:0071279)
Cellular response to copper ion
(GO:0071280)
Cellular response to hypoxia
(GO:0071456)
Cellular response to iron ion
(GO:0071281)
Cellular response to lead ion
(GO:0071284)
Cellular response to platelet-derived growth factor stimulus
(GO:0036120)
Central nervous system neuron development
(GO:0021954)
Cerebellar purkinje cell differentiation
(GO:0021702)
Collagen fibril organization
(GO:0030199)
Copper-dependent protein binding
(GO:0032767)
Copper ion binding
(GO:0005507)
Copper ion export
(GO:0060003)
Copper ion homeostasis
(GO:0055070)
Copper ion import
(GO:0015677)
Copper ion transmembrane transporter activity
(GO:0005375)
Copper ion transport
(GO:0006825)
Cuprous ion binding
(GO:1903136)
Dendrite morphogenesis
(GO:0048813)
Detoxification of copper ion
(GO:0010273)
Dopamine metabolic process
(GO:0042417)
Elastic fiber assembly
(GO:0048251)
Elastin biosynthetic process
(GO:0051542)
Endoplasmic reticulum
(GO:0005783)
Epinephrine metabolic process
(GO:0042414)
Establishment of localization in cell
(GO:0051649)
Extracellular matrix organization
(GO:0030198)
Female pregnancy
(GO:0007565)
Golgi apparatus
(GO:0005794)
Hair follicle morphogenesis
(GO:0031069)
Hindlimb morphogenesis
(GO:0035137)
Intracellular copper ion homeostasis
(GO:0006878)
In utero embryonic development
(GO:0001701)
Lactation
(GO:0007595)
Late endosome
(GO:0005770)
Liver development
(GO:0001889)
Locomotory behavior
(GO:0007626)
Lung alveolus development
(GO:0048286)
Metal ion binding
(GO:0046872)
Microvillus
(GO:0005902)
Mitochondrion organization
(GO:0007005)
Negative regulation of catecholamine metabolic process
(GO:0045914)
Negative regulation of iron ion transmembrane transport
(GO:0034760)
Negative regulation of neuron apoptotic process
(GO:0043524)
Neuron apoptotic process
(GO:0051402)
Neuron cellular homeostasis
(GO:0070050)
Neuron projection morphogenesis
(GO:0048812)
Norepinephrine biosynthetic process
(GO:0042421)
Norepinephrine metabolic process
(GO:0042415)
P-type divalent copper transporter activity
(GO:0043682)
P-type monovalent copper transporter activity
(GO:0140581)
Pigmentation
(GO:0043473)
Plasma membrane
(GO:0005886)
Positive regulation of cell size
(GO:0045793)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of lamellipodium assembly
(GO:0010592)
Positive regulation of melanin biosynthetic process
(GO:0048023)
Positive regulation of response to wounding
(GO:1903036)
Positive regulation of vascular associated smooth muscle cell migration
(GO:1904754)
Protein-folding chaperone binding
(GO:0051087)
Pyramidal neuron development
(GO:0021860)
Regulation of gene expression
(GO:0010468)
Regulation of oxidative phosphorylation
(GO:0002082)
Release of cytochrome c from mitochondria
(GO:0001836)
Removal of superoxide radicals
(GO:0019430)
Response to copper ion
(GO:0046688)
Response to iron(iii) ion
(GO:0010041)
Response to lead ion
(GO:0010288)
Response to manganese ion
(GO:0010042)
Response to zinc ion
(GO:0010043)
Serotonin metabolic process
(GO:0042428)
Skin development
(GO:0043588)
Small gtpase binding
(GO:0031267)
Superoxide dismutase copper chaperone activity
(GO:0016532)
T-helper cell differentiation
(GO:0042093)
Trans-golgi network
(GO:0005802)
Tryptophan metabolic process
(GO:0006568)
Tyrosine metabolic process
(GO:0006570)

Other Information

Proteins

Copper-transporting ATPase 1

Genular Protein ID: 1613200706

Symbol: ATP7A_RAT

Name: Copper-transporting ATPase 1

UniProtKB Accession Codes:

P70705

Database IDs:

Citations:

PubMed ID: 9562241

Title: Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases.

PubMed ID: 9562241

DOI: 10.1023/a:1006896612272

PubMed ID: 12488345

Title: Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase.

PubMed ID: 12488345

DOI: 10.1210/en.2002-220716

PubMed ID: 15634787

Title: NMDA receptor activation mediates copper homeostasis in hippocampal neurons.

PubMed ID: 15634787

DOI: 10.1523/jneurosci.3699-04.2005

PubMed ID: 16641100

Title: Quantitative phosphoproteomics of vasopressin-sensitive renal cells: regulation of aquaporin-2 phosphorylation at two sites.

PubMed ID: 16641100

DOI: 10.1073/pnas.0600895103

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

Length: 1492
Mass: 162093
Checksum: 34F75152B105AE9F
Sequence:

MEPNMDANSI TITVEGMTCI SCVRTIEQQI GKVNGVHHIK VSLEEKSATV IYNPKLQTPK 
TLQEAIDDMG FDALLHNANP LPVLTNTVFL TVTAPLALPW DHIQSTLLKT KGVTGVKISP 
QQRSAVVTII PSVVSANQIV ELVPDLSLDM GTQEKKSGTS EEHSTPQAGE VLLKMRVEGM 
TCHSCTSTIE GKVGKLQGVQ RIKVSLDNQE ATIVYQPHLI TAEEIKKQIE AVGFPAFIKK 
QPKYLKLGAI DVERLKSTPV KSSEGSQQKS PAYPSDSAIT FTIDGMHCKS CVSNIESALS 
TLQYVSSIVV SLENRSAIVK YNASLVTPEI LRKAIEAVSP GQYRVSISSE VESPTSSPSS 
SSLQKMPLNL VSQPLTQEVV ININGMTCNS CVQSIEGVIS KKPGVKSIHV SLTNSTGTIE 
YDPLLTSPEP LREAIEDMGF DAVLPADMKE PLVVIAQPSL ETPLLPSTTE PENVMTPVQN 
KCYIQVSGMT CASCVANIER NLRREEGIYS VLVALMAGKA EVRYNPAVIQ PRVIAELIRE 
LGFGAVVMEN AGEGNGILEL VVRGMTCASC VHKIESTLTK HKGIFYCSVA LATNKAHIKY 
DPEIIGPRDI IHTIGNLGFE ASLVKKDRSA NHLDHKREIK QWRGSFLVSL FFCIPVMGLM 
IYMMVMDHHL ATLNHNQNMS NEEMINMHSS MFLERQILPG LSIMNLLSLL LCLPVQFCGG 
WYFYIQAYKA LRHKTANMDV LIVLATTIAF AYSLVILLVA MYERAKVNPI TFFDTPPMLF 
VFIALGRWLE HIAKGKTSEA LAKLISLQAT EATIVTLNSE NLLLSEEQVD VELVQRGDII 
KVVPGGKFPV DGRVIEGHSM VDESLITGEA MPVAKKPGST VIAGSINQNG SLLIRATHVG 
ADTTLSQIVK LVEEAQTSKA PIQQFADKLS GYFVPFIVLV SIVTLLVWII IGFQNFEIVE 
AYFPGYNRSI SRTETIIRFA FQASITVLCI ACPCSLGLAT PTAVMVGTGV GAQNGILIKG 
GEPLEMAHKV KVVVFDKTGT ITHGTPVVNQ VKVLVESNKI SRNKILAIVG TAESNSEHPL 
GAAVTKYCKQ ELDTETLGTC TDFQVVPGCG ISCKVTNIEG LLHKSNLKIE ENNIKNASLV 
QIDAINEQSS PSSSMIIDAH LSNAVNTQQY KVLIGNREWM IRNGLVISND VDESMIEHER 
RGRTAVLVTI DDELCGLIAI ADTVKPEAEL AVHILKSMGL EVVLMTGDNS KTARSIASQV 
GITKVFAEVL PSHKVAKVKQ LQEEGKRVAM VGDGINDSPA LAMASVGIAI GTGTDVAIEA 
ADVVLIRNDL LDVVASIDLS RKTVKRIRIN FVFALIYNLI GIPIAAGVFL PIGLVLQPWM 
GSAAMAASSV SVVLSSLFLK LYRKPTYDNY ELRPRSHTGQ RSPSEISVHV GIDDTSRNSP 
RLGLLDRIVN YSRASINSLL SDKRSLNSVV TSEPDKHSLL VGDFREDDDT TL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp7a

Associated with

Other Information

Sequence of a Menkes-type Cu-transporting ATPase from rat C6 glioma cells: comparison of the rat protein with other mammalian Cu-transporting ATPases. PubMed ID: 9562241

Menkes protein contributes to the function of peptidylglycine alpha-amidating monooxygenase. PubMed ID: 12488345

NMDA receptor activation mediates copper homeostasis in hippocampal neurons. PubMed ID: 15634787