Genular: Defining Cellular Identity and Function

Details for: Chm

Gene ID: 24942

Symbol: Chm

Ensembl ID: ENSRNOG00000000161

Description: CHM Rab escort protein

Associated with

Gene expression (transcription)
(R-RNO-74160)
Generic transcription pathway
(R-RNO-212436)
Membrane trafficking
(R-RNO-199991)
Metabolism of proteins
(R-RNO-392499)
Post-translational protein modification
(R-RNO-597592)
Rab gefs exchange gtp for gdp on rabs
(R-RNO-8876198)
Rab geranylgeranylation
(R-RNO-8873719)
Rab regulation of trafficking
(R-RNO-9007101)
Rna polymerase ii transcription
(R-RNO-73857)
Tp53 regulates transcription of cell death genes
(R-RNO-5633008)
Tp53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
(R-RNO-6803205)
Transcriptional regulation by tp53
(R-RNO-3700989)
Blood vessel development
(GO:0001568)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Gdp-dissociation inhibitor activity
(GO:0005092)
Gtpase activator activity
(GO:0005096)
Intracellular protein transport
(GO:0006886)
Nucleus
(GO:0005634)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein geranylgeranylation
(GO:0018344)
Protein targeting to membrane
(GO:0006612)
Rab-protein geranylgeranyltransferase complex
(GO:0005968)
Small gtpase-mediated signal transduction
(GO:0007264)
Small gtpase binding
(GO:0031267)
Vesicle-mediated transport
(GO:0016192)

Other Information

Proteins

Rab proteins geranylgeranyltransferase component A 1

Genular Protein ID: 401582153

Symbol: RAE1_RAT

Name: Rab proteins geranylgeranyltransferase component A 1

UniProtKB Accession Codes:

P37727

Database IDs:

Citations:

PubMed ID: 8513495

Title: cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein.

PubMed ID: 8513495

DOI: 10.1016/0092-8674(93)90639-8

PubMed ID: 1525821

Title: Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product.

PubMed ID: 1525821

DOI: 10.1016/0092-8674(92)90253-9

PubMed ID: 11389151

Title: Membrane targeting of a Rab GTPase that fails to associate with Rab escort protein (REP) or guanine nucleotide dissociation inhibitor (GDI).

PubMed ID: 11389151

DOI: 10.1074/jbc.m101511200

PubMed ID: 11675392

Title: Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1.

PubMed ID: 11675392

DOI: 10.1074/jbc.m108241200

PubMed ID: 12356470

Title: Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae.

PubMed ID: 12356470

DOI: 10.1016/s1046-5928(02)00506-5

PubMed ID: 12620235

Title: Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase.

PubMed ID: 12620235

DOI: 10.1016/s1097-2765(03)00044-3

PubMed ID: 15186776

Title: Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease.

PubMed ID: 15186776

DOI: 10.1016/j.cell.2004.05.017

Sequence Information:

Length: 650
Mass: 72480
Checksum: 5BF42B445E546282
Sequence:

MADNLPSDFD VIVIGTGLPE SIIAAACSRS GQRVLHVDSR SYYGGNWASF SFSGLLSWLK 
EYQENNDVVT ENSMWQEQIL ENEEAIPLSS KDKTIQHVEV FCYASQDLHK DVEEAGALQK 
NHASVTSAQS AEAAEAAETS CLPTAVEPLS MGSCEIPAEQ SQCPGPESSP EVNDAEATGK 
KENSDAKSST EEPSENVPKV QDNTETPKKN RITYSQIIKE GRRFNIDLVS QLLYSRGLLI 
DLLIKSNVSR YAEFKNITRI LAFREGTVEQ VPCSRADVFN SKQLTMVEKR MLMKFLTFCV 
EYEEHPDEYR AYEGTTFSEY LKTQKLTPNL QYFVLHSIAM TSETTSCTVD GLKATKKFLQ 
CLGRYGNTPF LFPLYGQGEL PQCFCRMCAV FGGIYCLRHS VQCLVVDKES RKCKAVIDQF 
GQRIISKHFI IEDSYLSENT CSRVQYRQIS RAVLITDGSV LKTDADQQVS ILAVPAEEPG 
SFGVRVIELC SSTMTCMKGT YLVHLTCMSS KTAREDLERV VQKLFTPYTE IEAENEQVEK 
PRLLWALYFN MRDSSDISRD CYNDLPSNVY VCSGPDSGLG NDNAVKQAET LFQQICPNED 
FCPAPPNPED IVLDGDSSQQ EVPESSVTPE TNSETPKEST VLGNPEEPSE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chm

Associated with

Other Information

cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein. PubMed ID: 8513495

Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product. PubMed ID: 1525821

Membrane targeting of a Rab GTPase that fails to associate with Rab escort protein (REP) or guanine nucleotide dissociation inhibitor (GDI). PubMed ID: 11389151

Phosphoisoprenoids modulate association of Rab geranylgeranyltransferase with REP-1. PubMed ID: 11675392

Expression of mammalian Rab Escort protein-1 and -2 in yeast Saccharomyces cerevisiae. PubMed ID: 12356470

Structure of Rab escort protein-1 in complex with Rab geranylgeranyltransferase. PubMed ID: 12620235

Structure of the Rab7:REP-1 complex: insights into the mechanism of Rab prenylation and choroideremia disease. PubMed ID: 15186776